Separated by a common language: How Breitbart and The New York Times produce different meanings from common words

We build on the work by Peled and Bonotti to illuminate the impact of linguistic relativity on democratic debate. Peled and Bonotti’s focus is on multilingual societies, and their worry is that ‘unconscious epistemic effects’ can undermine political reasoning between interlocutors who do not share the same native tongue. Our article makes two contributions. First, we argue that Peled and Bonotti’s concerns about linguistic relativity are just as relevant to monolingual discourse. We use machine learning to provide novel evidence of the linguistic discrepancies between two ideologically distant groups that speak the same language: readers of Breitbart and of The New York Times. We suggest that intralinguistic relativity can be at least as harmful to successful public deliberation and political negotiation as interlinguistic relativity. Second, we endorse the building of metalinguistic awareness to address problematic kinds of linguistic relativity and argue that the method of discourse analysis we use in this article is a good way to build that awareness

The intricate Galaxy disk: velocity asymmetries in Gaia-TGAS

We use the Gaia-TGAS data to compare the transverse velocities in Galactic longitude (coming from proper motions and parallaxes) in the Milky Way disk for negative and positive longitudes as a function of distance. The transverse velocities are strongly asymmetric and deviate significantly from the expectations for an axisymmetric Galaxy. The value and sign of the asymmetry changes at spatial scales of several tens of degrees in Galactic longitude and about 0.5 kpc in distance. The asymmetry is statistically significant at 95% confidence level for 57% of the region probed, which extends up to ~1.2 kpc. A percentage of 24% of the region studied shows absolute differences at this confidence level larger than 5 km/s and 7% larger than 10 km/s. The asymmetry pattern shows mild variations in the vertical direction and with stellar type. A first qualitative comparison with spiral arm models indicates that the arms are unlikely to be the main source of the asymmetry. We briefly discuss alternative origins. This is the first time that global all-sky asymmetries are detected in the Milky Way kinematics, beyond the local neighbourhood, and with a purely astrometric sample.Comment: Accepted for publication in A&A Letter

VP66.23: Cervicovaginal localisation of non‐Hodgkin's lymphoma: ultrasound features

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Contribution of Organ Vasculature in Rat Renal Analysis for Ochratoxin A: Relevance to Toxicology of Nephrotoxins

Assumptions surrounding the kidney as a target for accumulation of ochratoxin A (OTA) are addressed because the contribution of the toxin in blood seems invariably to have been ignored. Adult rats were maintained for several weeks on toxin-contaminated feed. Using standard perfusion techniques, animals were anaesthetised, a blood sample was taken, one kidney was ligated, and the other kidney perfused with physiological saline in situ under normal blood pressure. Comparative analysis of OTA in pairs of kidneys showed marked reduction in the perfused organ in the range 37%–98% (mean 75%), demonstrating the general efficiency of perfusion supported also by histology, and implying a major role of blood in the total OTA content of kidney. Translation of OTA values in plasma to whole blood, and its predicted contribution as a 25% vascular compartment in kidney gave values similar to those in non-perfused kidneys. Thus, apparent ‘accumulation’ of OTA in kidney is due to binding to plasma proteins and long half-life in plasma. Attention should be re-focused on whole animal pharmacokinetics during chronic OTA exposure. Similar principles may be applied to DNA-OTA adducts which are now recognised as occurring in blood; application could also extend to other nephrotoxins such as aristolochic acid. Thus, at least, quantitative reassessment in urological tissues seems necessary in attributing adducts specifically as markers of potentially-tumourigenic exposure

Contraceptive trends and fetal outcome in women with short and long interpregnancy interval: a prospective observational study

Background: The present study was conducted at our tertiary health centre with the objective of analyzing contraceptive trends and fetal outcome in women with various interpregnancy interval (IPI). Methods: The present study was a prospective observational study. Women were segregated into three categories as per their IPI (short, normal and long) and contraceptive trends and fetal outcome were deliberated. All women attending ANC clinic with previous pregnancy, regardless of outcome and registration status were included in our study. Results: We found that 21.1% of women with short IPI were unaware about contraception and this difference was statistically significant. It was seen that among women not using any method of contraception, majority had short ICP, almost 31.1% cases. This difference was also statistically significant. Amidst those with adverse outcomes of previous pregnancy, i.e. 169 cases, 87 cases i.e. 51.5% of the women conceived within 2 years. Short IPI is linked with an escalated risk of low birth weight, preterm birth and congenital anomaly whereas long IPI caused large for gestational age babies. Conclusions: Contraception and previous pregnancy outcome have a significant effect on interpregnancy interval which in turn affects the maternal and fetal outcome. So it is essential to maintain an optimum interpregnancy interval as most of these complications are avoidable. Short interpregnancy interval is associated with low birth weight, preterm and congenital anomaly whereas long interpregnancy interval is associated with large for gestational age babies

BGM FASt: Besan\c{c}on Galaxy Model for Big Data. Simultaneous inference of the IMF, SFH and density in the Solar Neighbourhood

We develop a new theoretical framework to generate Besan\c{c}on Galaxy Model fast approximate simulations (BGM FASt) to address fundamental questions of the Galactic structure and evolution performing multi-parameter inference. As a first application of our strategy we simultaneously infer the IMF, the star formation history and the stellar mass density in the Solar Neighbourhood. The BGM FASt strategy is based on a reweighing scheme, that uses a specific pre-sampled simulation, and on the assumption that the distribution function of the generated stars in the Galaxy can be described by an analytical expression. To validate BGM FASt we execute a set of tests. Finally, we use BGM FASt with an approximate Bayesian computation algorithm to obtain the posterior PDF of the inferred parameters, by comparing synthetic versus Tycho-2 colour-magnitude diagrams. Results: The validation shows a very good agreement between BGM FASt and the standard BGM, with BGM FASt being $\approx 10^4$ times faster. By analysing Tycho-2 data we obtain a thin disc star formation history decreasing in time and a present rate of $1.2 \pm 0.2 M_\odot/yr$. The resulting total stellar mass density in the Solar Neighbourhood is $0.051_{-0.005}^{+0.002} M_\odot/pc^3$ and the local dark matter density is $0.012 \pm 0.001 M_\odot/pc^3$. For the composite IMF we obtain a slope of $\alpha_2={2.1}_{-0.3}^{+0.1}$ in the mass range between $0.5 M_\odot$ and $1.53M_\odot$. The results of the slope at the high mass range are trustable up to $4M_\odot$ and highly depend on the choice of the extinction map (obtaining $\alpha_3={2.9}_{-0.2}^{+0.2}$ and $\alpha_3={3.7}_{-0.2}^{+0.2}$ respectively, for two different extinction maps). Systematic uncertainties are not included. Conclusions: The good performance of BGM FASt demonstrates that it is a very valuable tool to perform multi-parameter inference using Gaia data releases.Comment: Accepted for publication by A&A. 30 pages (23 pages of main body and 7 pages of Appendixes) , 15 figures and 4 table

Gaia DR2 view of the Lupus V-VI clouds: the candidate diskless young stellar objects are mainly background contaminants

Extensive surveys of star-forming regions with Spitzer have revealed populations of disk-bearing young stellar objects. These have provided crucial constraints, such as the timescale of dispersal of protoplanetary disks, obtained by carefully combining infrared data with spectroscopic or X-ray data. While observations in various regions agree with the general trend of decreasing disk fraction with age, the Lupus V and VI regions appeared to have been at odds, having an extremely low disk fraction. Here we show, using the recent Gaia data release 2 (DR2), that these extremely low disk fractions are actually due to a very high contamination by background giants. Out of the 83 candidate young stellar objects (YSOs) in these clouds observed by Gaia, only five have distances of 150 pc, similar to YSOs in the other Lupus clouds, and have similar proper motions to other members in this star-forming complex. Of these five targets, four have optically thick (Class II) disks. On the one hand, this result resolves the conundrum of the puzzling low disk fraction in these clouds, while, on the other hand, it further clarifies the need to confirm the Spitzer selected diskless population with other tracers, especially in regions at low galactic latitude like Lupus V and VI. The use of Gaia astrometry is now an independent and reliable way to further assess the membership of candidate YSOs in these, and potentially other, star-forming regions.Comment: Accepted for publication on Astronomy&Astrophysics Letter

Nonlinear Qubit Transformations

We generalise our previous results of universal linear manipulations [Phys. Rev. A63, 032304 (2001)] to investigate three types of nonlinear qubit transformations using measurement and quantum based schemes. Firstly, nonlinear rotations are studied. We rotate different parts of a Bloch sphere in opposite directions about the z-axis. The second transformation is a map which sends a qubit to its orthogonal state (which we define as ORTHOG). We consider the case when the ORTHOG is applied to only a partial area of a Bloch sphere. We also study nonlinear general transformation, i.e. (theta,phi)->(theta-alpha,phi), again, applied only to part of the Bloch sphere. In order to achieve these three operations, we consider different measurement preparations and derive the optimal average (instead of universal) quantum unitary transformations. We also introduce a simple method for a qubit measurement and its application to other cases.Comment: minor corrections. To appear in PR

Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase

N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) hydrolase that catalyses the intracellular deactivation of the endogenous analgesic and anti-inflammatory agent palmitoylethanolamide (PEA). NAAA inhibitors counteract this process and exert marked therapeutic effects in animal models of pain, inflammation and neurodegeneration. While it is known that NAAA preferentially hydrolyses saturated fatty acid ethanolamides (FAEs), a detailed profile of the relationship between catalytic efficiency and fatty acid-chain length is still lacking. In this report, we combined enzymatic and molecular modelling approaches to determine the effects of acyl chain and polar head modifications on substrate recognition and hydrolysis by NAAA. The results show that, in both saturated and monounsaturated FAEs, the catalytic efficiency is strictly dependent upon fatty acyl chain length, whereas there is a wider tolerance for modifications of the polar heads. This relationship reflects the relative stability of enzyme-substrate complexes in molecular dynamics simulations

Design approaches in technology enhanced learning

Design is a critical to the successful development of any interactive learning environment (ILE). Moreover, in technology enhanced learning (TEL), the design process requires input from many diverse areas of expertise. As such, anyone undertaking tool development is required to directly address the design challenge from multiple perspectives. We provide a motivation and rationale for design approaches for learning technologies that draws upon Simon's seminal proposition of Design Science (Simon, 1969). We then review the application of Design Experiments (Brown, 1992) and Design Patterns (Alexander et al., 1977) and argue that a patterns approach has the potential to address many of the critical challenges faced by learning technologists