Using pressure pulse seismology to examine basal criticality and the influence of sticky spots on glacial flow

Here we report results of water pressure pulse studies conducted at Storglaciären (Sweden) and West Washmawapta Glacier (British Columbia, Canada). Comparison of pressure pulse records with meteorological conditions at Storglaciären indicates that several periods of increased basal slip activity observed during a 10 day interval of summer 2008 were due to precipitation loading of the glacier surface, rather than to infiltration of surface water to the glacier bed; this indicates that the glacier bed was close to the failure strength for much of this interval. Pressure pulse magnitudes for the two glaciers were well-fit by power law distributions similar to those earlier observed at Trapridge Glacier (and similar in form to the Gutenberg-Richter relationship commonly used in seismology), suggesting that the mechanical processes that give rise to these distributions are robust features of soft-bedded glaciers. In contrast, interevent time distributions for both glaciers diverge from those observed at Trapridge Glacier for short recurrence intervals, suggesting that the factors that govern the rate at which these processes occur differ between glaciers. An examination of pressure pulse characteristics at West Washmawapta Glacier indicates that the establishment of a basal drainage system in summer 2008 resulted in increased stability and reduced sensitivity to meltwater input, suggesting that common assumptions about the relationship between meltwater production and ice flow are oversimplified. These results demonstrate that water pressure pulse observations can provide valuable insight into the dynamics of soft-bedded glaciers

CHIRON - A Fiber Fed Spectrometer for Precise Radial Velocities

The CHIRON optical high-resolution echelle spectrometer was commissioned at the 1.5m telescope at CTIO in 2011. The instrument was designed for high throughput and stability, with the goal of monitoring radial velocities of bright stars with high precision and high cadence for the discovery of low-mass exoplanets. Spectral resolution of R=79,000 is attained when using a slicer with a total (including telescope and detector) efficiency of 6% or higher, while a resolution of R=136,000 is available for bright stars. A fixed spectral range of 415 to 880 nm is covered. The echelle grating is housed in a vacuum enclosure and the instrument temperature is stabilized to +-0.2deg. Stable illumination is provided by an octagonal multimode fiber with excellent light-scrambling properties. An iodine cell is used for wavelength calibration. We describe the main optics, fiber feed, detector, exposure-meter, and other aspects of the instrument, as well as the observing procedure and data reduction.Comment: 15 pages, 10 figures. Accepted by PAS

MindSeer: a portable and extensible tool for visualization of structural and functional neuroimaging data

Three-dimensional (3-D) visualization of multimodality neuroimaging data provides a powerful technique for viewing the relationship between structure and function. A number of applications are available that include some aspect of 3-D visualization, including both free and commercial products. These applications range from highly specific programs for a single modality, to general purpose toolkits that include many image processing functions in addition to visualization. However, few if any of these combine both stand-alone and remote multi-modality visualization in an open source, portable and extensible tool that is easy to install and use, yet can be included as a component of a larger information system. We have developed a new open source multimodality 3-D visualization application, called MindSeer, that has these features: integrated and interactive 3-D volume and surface visualization, Java and Java3D for true cross-platform portability, one-click installation and startup, integrated data management to help organize large studies, extensibility through plugins, transparent remote visualization, and the ability to be integrated into larger information management systems. We describe the design and implementation of the system, as well as several case studies that demonstrate its utility. These case studies are available as tutorials or demos on the associated website: http://sig.biostr.washington.edu/projects/MindSeer MindSeer provides a powerful visualization tool for multimodality neuroimaging data. Its architecture and unique features also allow it to be extended into other visualization domains within biomedicine

Structural role of the tyrosine residues of cytochrome c

The tertiary structures of horse, tuna, Neurospora crassa, horse [Hse65,Leu67]- and horse [Hse65,Leu74]-cytochromes c were studied with high-resolution 1H n.m.r. spectroscopy. The amino acid sequences of these proteins differ at position 46, which is occupied by phenylalanine in the horse proteins but by tyrosine in the remaining two, and at positions 67, 74 and 97, which are all occupied by tyrosine residues in horse and tuna cytochrome c but in the other proteins are substituted by phenylalanine or leucine, though there is only one such substitution per protein. The various aromatic-amino-acid substitutions do not seriously affect the protein structure

Pre-Maximum Spectropolarimetry of the Type Ia SN 2004dt

We report observations of SN 2004dt obtained with the Very Large Telescope of the European Southern Observatory on August 13.30, 2004 when the supernova was more than a week before optical maximum. SN 2004dt showed strong lines of \ion{O}{1}, \ion{Mg}{2}, \ion{Si}{2}, and \ion{Ca}{2} with typical velocities of absorption minimum around 17,000 \kms. The line profiles show material moving at velocities as high as 25,000 \kms in these lines. The observations also reveal absorption lines from \ion{S}{2} and \ion{Si}{3} with a velocity of only 11,000 \kms. The highest velocity in the \ion{S}{2} features can be traced no higher than 15,000 \kms, much lower than those of O, Mg, Si, and Ca. SN 2004dt has a polarization spectrum unlike any previously observed. The variation of the polarization across some \ion{Si}{2} lines approaches 2%, making SN 2004dt the most highly polarized SN Ia ever observed. In contrast, the strong line of O I at 777.4 nm shows little or no polarization signature. The degree of polarization points to a richly-structured partially burned silicon layer with substantial departure from spherical symmetry. A geometry that would account for the observations is one in which the distribution of oxygen is essentially spherically symmetric, but with bubbles of intermediate-mass elements with significant opacity within the oxygen substrate.Comment: Submitted to Ap

Experimental design of complement component 5a‐induced acute lung injury (C5a‐ALI): a role of CC‐chemokine receptor type 5 during immune activation by anaphylatoxin

Excessive activation of the complement system is detrimental in acute inflammatory disorders. In this study, we analyzed the role of complement‐derived anaphylatoxins in the pathogenesis of experimental acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in C57BL/6J mice. Intratracheal administration of recombinant mouse complement component (C5a) caused alveolar inflammation with abundant recruitment of Ly6‐G+CD11b+ leukocytes to the alveolar spaces and severe alveolar‐capillary barrier dysfunction (C5a‐ALI; EC50[C5a] = 20 ng/g body weight). Equimolar concentrations of C3a or desarginated C5a (C5adesArg) did not induce alveolar inflammation. The severity of C5a‐ALI was aggravated in C5‐deficient mice. Depletion of Ly6‐G+ cells and use of C5aR1‐/‐ bone marrow chimeras suggested an essential role of C5aR1+ hematopoietic cells in C5a‐ALI. Blockade of PI3K/Akt and MEK1/2 kinase pathways completely abrogated lung injury. The mechanistic description is that C5a altered the alveolar cytokine milieu and caused significant release of CC‐chemokines. Mice with genetic deficiency of CC‐chemokine receptor (CCR) type 5, the common receptor of chemokine (C‐C motif) ligand (CCL) 3, CCL4, and CCL5, displayed reduced lung damage. Moreover, treatment with a CCR5 antagonist, maraviroc, was protective against C5a‐ALI. In summary, our results suggest that the detrimental effects of C5a in this model are partly mediated through CCR5 activation downstream of C5aR1, which may be evaluated for potential therapeutic exploitation in ALI/ARDS.—Russkamp, N. F., Ruemmler, R., Roewe, J., Moore, B. B., Ward, P. A., Bosmann, M. Experimental design of complement component 5a‐induced acute lung injury (C5a‐ALI): a role of CC‐chemokine receptor type 5 during immune activation by anaphylatoxin. FASEB J. 29, 3762‐3772 (2015). www.fasebj.orgPeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154372/1/fsb2029009014.pd

Assessment and practical science:identifying generalizable characteristics of written assessments that reward and incentivise effective practices in practical science lessons

High-stakes assessments prominently influence what is done in secondary school science lessons (‘washback’ effects). It is therefore important that assessments of knowledge and understanding gained from practical work are constructed to reward and incentivise effective practices in practical work. To do that, they must differentiate between pupils who have experienced practical work in different ways. This empirical, mixed-methods study identifies generalizable characteristics of written assessments that differentially reward pupils who experienced practical activities through hands-on work, teacher demonstration, video demonstration, or reading about the activity. Conclusions are drawn from 1486 post-intervention tests completed by pupils aged 14–15 in England, from lesson observations and teacher interviews. This study also identifies pedagogical practices that were more noticeable in practical work that was most rewarded by the written assessments: the work was teacher-guided; and pupils were encouraged to be active participants. Existing literature describes negative washback effects of high-stakes, written assessments that limit the use and effectiveness of practical work as a pedagogical tool. We describe ways in which written assessments could be constructed to better reward effective practices in practical work (practices that better support learning), with the intention of having positive washback effects on pedagogy by better incentivising these practices

Effective Kinetic Theory for High Temperature Gauge Theories

Quasiparticle dynamics in relativistic plasmas associated with hot, weakly-coupled gauge theories (such as QCD at asymptotically high temperature $T$) can be described by an effective kinetic theory, valid on sufficiently large time and distance scales. The appropriate Boltzmann equations depend on effective scattering rates for various types of collisions that can occur in the plasma. The resulting effective kinetic theory may be used to evaluate observables which are dominantly sensitive to the dynamics of typical ultrarelativistic excitations. This includes transport coefficients (viscosities and diffusion constants) and energy loss rates. We show how to formulate effective Boltzmann equations which will be adequate to compute such observables to leading order in the running coupling $g(T)$ of high-temperature gauge theories [and all orders in $1/\log g(T)^{-1}$]. As previously proposed in the literature, a leading-order treatment requires including both $22$ particle scattering processes as well as effective ``$12$'' collinear splitting processes in the Boltzmann equations. The latter account for nearly collinear bremsstrahlung and pair production/annihilation processes which take place in the presence of fluctuations in the background gauge field. Our effective kinetic theory is applicable not only to near-equilibrium systems (relevant for the calculation of transport coefficients), but also to highly non-equilibrium situations, provided some simple conditions on distribution functions are satisfied.Comment: 40 pages, new subsection on soft gauge field instabilities adde

Effective theories for real-time correlations in hot plasmas

We discuss the sequence of effective theories needed to understand the qualitative, and quantitative, behavior of real-time correlators in ultra-relativistic plasmas. We analyze in detail the case where A is a gauge-invariant conserved current. This case is of interest because it includes a correlation recently measured in lattice simulations of classical, hot, SU(2)-Higgs gauge theory. We find that simple perturbation theory, free kinetic theory, linearized kinetic theory, and hydrodynamics are all needed to understand the correlation for different ranges of time. We emphasize how correlations generically have power-law decays at very large times due to non-linear couplings to long-lived hydrodynamic modes.Comment: 28 pages, Latex, uses revtex, epsf macro packages [Revised version: t -> sqrt{t} in a few typos on p. 10.

Structure and magnetic properties of the cubic oxide fluoride BaFeO2F

Fluorination of the parent oxide, BaFeO3- δ, with polyvinylidine fluoride gives rise to a cubic compound with a = 4.0603(4) Å at 298K. 57Fe Mössbauer spectra confirmed that all the iron is present as Fe3+. Neutron diffraction data showed complete occupancy of the anion sites indicating a composition BaFeO2F, with a large displacement of the iron off-site. The magnetic ordering temperature was determined as TN = 645±5K. Neutron diffraction data at 4.2K established G-type antiferromagnetism with a magnetic moment per Fe3+ ion of 3.95μB. However, magnetisation measurements indicated the presence of a weak ferromagnetic moment which is assigned to the canting of the antiferromagnetic structure. 57Fe Mössbauer spectra in the temperature range 10 to 300K were fitted with a model of fluoride ion distribution that retains charge neutrality of the perovskite unit cel