Acute Effect of Moderate-Intensity Aerobic Exercise on Arterial Stiffness in Fine Particulate Matter Environment: A Pilot Study

Abstracts PURPOSE This study aimed to examine the effect of one bout of moderate-intensity aerobic exercise on arterial stiffness under ambient fine particulate matter (PM2.5) exposure. METHODS In a randomized crossover design, seven healthy young men performed 30 minutes of treadmill running at 70% of heart rate peak under high PM2.5 and low PM2.5 exposure. Arterial stiffness was assessed by measuring the carotid-femoral pulse wave velocity and augmentation index, a measure of pulse wave reflection before and after each exercise intervention. RESULTS Regardless of the PM2.5 exposure, brachial systolic blood pressure and heart rate increased in response to one bout of moderate-intensity aerobic exercise (p<.05). However, the augmentation index adjusted at a heart rate of 75 beats/min, central diastolic blood pressure, central mean arterial pressure, and brachial diastolic blood pressure were increased after one bout of moderate-intensity aerobic exercise under the high PM2.5 condition (p<.05). CONCLUSIONS Moderate-intensity aerobic exercise at the high PM2.5 level may result in acute negative arterial stiffness and blood pressure responses even in healthy young men

Influence of Physical Activity Level on Cardiovascular and Autonomic Nerve Function

PURPOSE The purpose of this study was to demonstrate differences in cardiovascular and autonomic nerve function among physical activity levels and associations between physical activity level and cardiovascular and autonomic nerve function. METHODS Sixty-six healthy young adults voluntarily participated in this cross-sectional study. Physical activity levels were assessed using triaxial accelerometers for 7 consecutive days. Central hemodynamics and arterial stiffness were measured using the Sphygomo-Cor Xcel system. Autonomic nerve function was assessed by heart rate variability. RESULTS The highest tertile group of the total quantity of physical activity had higher lnRMSSD than did the lowest tertile group (p=0.047). The augmentation index adjusted for heart rate at 75 beats per min (AIx@75) was lower in the highest tertile group of vig-orous-intensity physical activity than in the lowest tertile group (p=0.012). Moreover, AIx@75 was negatively associated with vigorous-intensity physical activity (r=-0.27, p=0.028). CONCLUSIONS High levels of physical activity contribute to the dominance of parasympathetic nerve activity at rest. Increased engagement in vigorous-intensity physical activity can help reduce arterial pulse wave reflection, an independent risk factor for cardiovascular diseases, even in healthy young adults

Mineralocorticoid receptors modulate vascular endothelial function in human obesity

Abstract Obesity increases linearly with age and is associated with impaired vascular endothelial function and increased risk of cardiovascular disease. MRs (mineralocorticoid receptors) contribute to impaired vascular endothelial function in cardiovascular disease; however, their role in uncomplicated human obesity is unknown. Because plasma aldosterone levels are elevated in obesity and adipocytes may be a source of aldosterone, we hypothesized that MRs modulate vascular endothelial function in older adults in an adiposity-dependent manner. To test this hypothesis, we administered MR blockade (eplerenone; 100 mg/day) for 1 month in a balanced randomized double-blind placebo-controlled cross-over study to 22 older adults (ten men, 55--79 years) varying widely in adiposity [BMI (body mass index): 20--45 kg/m 2 ], but who were free from overt cardiovascular disease. We evaluated vascular endothelial function [brachial artery FMD (flow-mediated dilation)] via ultrasonography) and oxidative stress (plasma F 2 -isoprostanes and vascular endothelial cell protein expression of nitrotyrosine and NADPH oxidase p47 phox ) during placebo and MR blockade. In the whole group, oxidative stress (P &gt; 0.05) and FMD did not change with MR blockade (6.39 + − 0.67 compared with 6.23 + − 0.73 %; P = 0.7). However, individual improvements in FMD in response to eplerenone were associated with higher total body fat (BMI: r = 0.45, P = 0.02; and dual-energy X-ray absorptiometry-derived percentage body fat: r = 0.50, P = 0.009) and abdominal fat (total: r = 0.61, P = 0.005; visceral: r = 0.67, P = 0.002; and subcutaneous: r = 0.48, P = 0.03). In addition, greater improvements in FMD with eplerenone were related to higher baseline fasting glucose (r = 0.53, P = 0.01). MRs influence vascular endothelial function in an adiposity-dependent manner in healthy older adults

Efficacies of the new Paclitaxel-eluting Coroflex Please™ Stent in percutaneous coronary intervention; comparison of efficacy between Coroflex Please™ and Taxus™ (ECO-PLEASANT) trial: study rationale and design

<p>Abstract</p> <p>Background</p> <p>Previous randomized trials have showed the superiority of Paclitaxel-eluting stent over bare metal stent in angiographic and clinical outcomes. Coroflex Please™ stent is a newly developed drug eluting stent using the Coroflex™ stent platform combined with the drug paclitaxel contained in a polymer coating. PECOPS I trial, one-arm observational study, showed that the clinical and angiographic outcomes of Coroflex Please™ stent were within the range of those of Taxus, the 1^stgeneration paclitaxel-eluting stent (PES). However, there have been no studies directly comparing the Coroflex Please™ stent with the Taxus Liberte™ stent that is the newest version of Taxus. Therefore, prospective, randomized trial is required to demonstrate the non-inferiority of Coroflex Please™ stent compared with Taxus Liberte™ stent in a head-to-head manner.</p> <p>Methods</p> <p>In the comparison of Efficacy between COroflex PLEASe™ ANd Taxus™ stent(ECO-PLEASANT) trial, approximately 900 patients are being prospectively and randomly assigned to the either type of Coroflex Please™ stent and Taxus Liberte™ stent via web-based randomization. The primary endpoint is clinically driven target vessel revascularization at 9 months. The secondary endpoints include major cardiac adverse events, target vessel failure, stent thrombosis and angiographic efficacy endpoints.</p> <p>Discussion</p> <p>The ECO-PLEASANT trial is the study not yet performed to directly compare the efficacy and safety of the Coroflex Please™ versus Taxus Liberte™ stent. On the basis of this trial, we will be able to find out whether the Coroflex Please™ stent is non-inferior to Taxus Liberte™ stent or not.</p> <p>Trial registration</p> <p>ClinicalTrials.gov number, NCT00699543.</p

Insulin resistance: vascular function and exercise

AbstractInsulin resistance associated with metabolic syndrome and Type 2 diabetes mellitus is an epidemic metabolic disorder, which increases the risk of cardiovascular complications. Impaired vascular endothelial function is an early marker for atherosclerosis, which causes cardiovascular complications. Both experimental and clinical studies indicate that endothelial dysfunction in vasculatures occurs with insulin resistance. The associated physiological mechanisms are not fully appreciated yet, however, it seems that augmented oxidative stress, a physiological imbalance between oxidants and antioxidants, in vascular cells is a possible mechanism involved in various vascular beds with insulin resistance and hyperglycemia. Regardless of the inclusion of resistance exercise, aerobic exercise seems to be beneficial for vascular endothelial function in both large conduit and small resistance vessels in both clinical and experimental studies with insulin resistance. In clinical cases, aerobic exercise over 8 weeks with higher intensity seems more beneficial than the cases with shorter duration and lower intensity. However, more studies are needed in the future to elucidate the physiological mechanisms by which vascular endothelial function is impaired in insulin resistance and improved with aerobic exercise

A Potential Health Risk to Occupational User from Exposure to Biocidal Active Chemicals

Biocidal active chemicals have potential health risks associated with exposure to retail biocide products such as disinfectants for COVID-19. Reliable exposure assessment was investigated to understand the exposure pattern of biocidal products used by occupational workers in their place of occupation, multi-use facilities, and general facilities. The interview&ndash;survey approach was taken to obtain the database about several subcategories of twelve occupational groups, the use pattern, and the exposure information of non-human hygiene disinfectant and insecticide products in workplaces. Furthermore, we investigated valuable exposure factors, e.g., the patterns of use, exposure routes, and quantifying potential hazardous chemical intake, on biocidal active ingredients. We focused on biocidal active-ingredient exposure from products used by twelve occupational worker groups. The 685 non-human hygiene disinfectants and 763 insecticides identified contained 152 and 97 different active-ingredient chemicals, respectively. The toxicity values and clinical health effects of total twelve ingredient chemicals were determined through a brief overview of toxicity studies aimed at estimating human health risks. To estimate actual exposure amounts divided by twelve occupational groups, the time spent to apply the products was investigated from the beginning to end of the product use. This study investigated the exposure assessment of occupational exposure to biocidal products used in workplaces, multi-use facilities, and general facilities. Furthermore, this study provides valuable information on occupational exposure that may be useful to conduct accurate exposure assessment and to manage products used for quarantine in general facilities

The relationship between arterial stiffness and maximal oxygen consumption in healthy young adults

Objective: Arterial stiffness is associated with an increased risk of cardiovascular diseases in various populations. There was little research on the relationship between arterial stiffness and maximal aerobic capacity (VO2max) in healthy young adults. The aim of this study was to investigate the relationship between VO2max and arterial stiffness in young adults. Methods: The subjects were 13 men and 10 women with mean age of 22.9 ± 0.7, 23.6 ± 0.4 years, respectively. Height, weight, body mass index, body fat (%), waist to hip ratio, total/high density lipoprotein (HDL)/low density lipoprotein (LDL) cholesterol, triglycerides, fasting glucose, blood pressure, heart rate, glycated hemoglobin and blood lactate were measured. In addition, peripheral arterial stiffness was assessed by measuring brachial-ankle pulse wave velocity (baPWV) and VO2max was determined using graded exercise test. Results: VO2max had no significant correlation with baPWV (r = 0.2, p = 0.2). Total cholesterol correlated significantly to variables such as HDL (r = 0.6, p = 0.0015) and LDL cholesterol (r = −0.6, p = 0.0018). VO2max had a significant association with triglyceride (r = −0.5, p = 0.0033). Conclusions: This study suggests that there is no relationship between arterial stiffness and aerobic capacity in healthy young adults. Keywords: Arterial stiffness, Aerobic capacity, baPWV, VO2ma

Acute Moderate-Intensity Aerobic Exercise under High PM2.5 Levels Does Not Influence the Pulmonary Function and Lung Diffusion Capacity in Healthy Young Men

Exposure to fine particulate matter (PM2.5) impairs the respiratory system and increases the morbidity and mortality of respiratory diseases. Even though aerobic exercise is known to improve pulmonary function in diverse populations, it can lead to an increase in the inhalation of PM2.5 in polluted environments. We aimed to investigate the effects of aerobic exercise under high PM2.5 conditions on the pulmonary function in young adults. Nine healthy young men performed indoor treadmill running in both high and low PM2.5 conditions (59.0 &plusmn; 2.1 vs. 7.8 &plusmn; 1.0 &mu;g/m3) by a crossover study design. Pulmonary function was assessed by spirometry and diffusing capacity for carbon monoxide (DLCO) at pre- and 1-h post-exercise. There was no difference in the response of pulmonary function and lung diffusion capacity to the acute aerobic exercise in high and low PM2.5 conditions (p &ge; 0.09). These findings indicate that aerobic exercise in high PM2.5 conditions may not adversely affect pulmonary function in healthy young adults

Acute Moderate-Intensity Aerobic Exercise under High PM_2.5 Levels Does Not Influence the Pulmonary Function and Lung Diffusion Capacity in Healthy Young Men

Exposure to fine particulate matter (PM2.5) impairs the respiratory system and increases the morbidity and mortality of respiratory diseases. Even though aerobic exercise is known to improve pulmonary function in diverse populations, it can lead to an increase in the inhalation of PM2.5 in polluted environments. We aimed to investigate the effects of aerobic exercise under high PM2.5 conditions on the pulmonary function in young adults. Nine healthy young men performed indoor treadmill running in both high and low PM2.5 conditions (59.0 ± 2.1 vs. 7.8 ± 1.0 μg/m3) by a crossover study design. Pulmonary function was assessed by spirometry and diffusing capacity for carbon monoxide (DLCO) at pre- and 1-h post-exercise. There was no difference in the response of pulmonary function and lung diffusion capacity to the acute aerobic exercise in high and low PM2.5 conditions (p ≥ 0.09). These findings indicate that aerobic exercise in high PM2.5 conditions may not adversely affect pulmonary function in healthy young adults