Fabrication of n-type nanotube transistors with large-work-function electrodes

The authors found experimentally that carbon nanotube field-effect transistors (CNFETs) could exhibit n -type characteristics even though their electrodes consist of a large-work-function metal such as Co. To explain their result, which is contrary to the general belief that CNFETs with large-work-function electrodes always lead to p -type characteristics, ab initio electronic structure calculation for the metal-carbon nanotube junction was performed, which showed that the Fermi level alignment at the junction could sensitively depend on microscopic structures of the metal-carbon nanotube junction. This suggests that deposition method of electrodes as well as the metal type could be utilized to obtain n -type CNFETs.open121

Discovery of GSK3β Inhibitors through In Silico Prediction-and-Experiment Cycling Strategy, and Biological Evaluation

Direct inhibitors of glycogen synthase kinase 3β (GSK3β) have been investigated and reported for the past 20 years. In the search for novel scaffold inhibitors, 3000 compounds were selected through structure-based virtual screening (SBVS), and then high-throughput enzyme screening was performed. Among the active hit compounds, pyrazolo [1,5-a]pyrimidin-7-amine derivatives showed strong inhibitory potencies on the GSK3β enzyme and markedly activated Wnt signaling. The result of the molecular dynamics (MD) simulation, enhanced by the upper-wall restraint, was used as an advanced structural query for the SBVS. In this study, strong inhibitors designed to inhibit the GSK3β enzyme were discovered through SBVS. Our study provides structural insights into the binding mode of the inhibitors for further lead optimization