Codisseny d’una eina web per fomentar les decisions compartides en persones amb esclerosi múltiple

Esclerosi múltiple; Tractament; Decisions compartides; Eines d'ajudaEsclerosis múltiple; Tratamiento; Decisiones compartidas; Herramientas de ayudaMultiple sclerosis; Treatment; Shared decisions; Help toolsPer apoderar les persones amb esclerosi múltiple en la gestió de la seva salut és essencial desenvolupar un lloc web i una eina de suport que permetin involucrar persones en la seva pròpia assistència sanitària i millorar la seva alfabetització en salut, promovent un model de presa de decisions compartit per a la selecció del tractament de l’esclerosi múltiple. L'article explica el desenvolupament del lloc web i l’eina de suport disponibles en accés obert a través de Canal Salut (http://decisionscompartides.gencat.cat/ca/inici/)

Views of Multiple Sclerosis Patients About Key Elements for a Decision Aid: A Qualitative Study

Multiple SclerosisEsclerosi múltipleEsclerosis múltipleBACKGROUND: Patients with multiple sclerosis (MS) may experience decisional conflict during treatment choice. Shared decision making (SDM), whereby patients and health professionals, primarily nurses, collaborate in making decisions, reduces this decisional conflict. It requires understanding large amounts of information and may be complex, especially when decisions affect patients' autonomy and quality and prolongation of life. Patient decision aids are tools in facilitating SDM. This study aimed to identify the key elements from the perspective of patients with relapsing-remitting MS to create a patient decision aid in the Spanish sociocultural context. METHODS: This is a qualitative study using focus groups led by a clinical nurse specialist. Semistructured interviews included healthcare needs and demands, the SDM process, and general characteristics of a peer support program. After the transcription of interview recordings, data were analyzed by thematic analysis and a constructivist naturalistic approach. RESULTS: Patients with MS (27) from Spain participated in 4 focus groups of 90 to 120 minutes each. Three overarching themes were identified: information access to sufficient high-quality data; knowledge of available treatment options, including efficacy, adverse effects, frequency, administration route, and the impact on daily life; decision-making role, engaged versus nonengaged patients. The former require support in facilitating their active involvement in decisions, whereas the latter prefer more passive health models. CONCLUSION: The needs identified by patients with relapsing-remitting MS regarding treatment choice in the Spanish setting align with those reported by other studies. The identified themes provide valuable information to design and develop a virtual patient decision aid jointly by clinical MS nurses and patients according to the International Patient Decision Aid Standards Collaboration criteria. This aid will help improve understanding between nurses and patients during SDM and facilitate the process

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Wreckfish (Polyprion americanus). New Knowledge about reproduction, larval husbandry and nutrition. Promise a new species for aquaculture

Four different wreckfish (Polyprion americanus) broodstock batches were maintained in research facilities under different photo and thermo-period conditions, one in Greece, the Helenic Center for Marine Research (HCMR, n = 3) and three in Spain: Instituto Español de Oceanografía (IEO, n = 13) in Vigo, Aquarium Finisterrae (MC2, n = 21) in A Coruña and Consellería do Mar (CMRM, n = 11). The CMRM includes two centers that work together: Instituto Galego de Formación en Acuicultura (IGAFA) and Centro de Investigacións Mariñas (CIMA), both in Pontevedra. During the five years of the project DIVERSIFY (Exploring the biological and socio-economic potential of new-emerging candidate fish species for the expansion of the European aquaculture industry, 2013–2018) works focused on the reproductive biology of the species, broodstock, and larvae nutrition and development of incubation and larval rearing protocols have been carried out. In terms of reproduction, catch methods of new wild animals, the reproductive cycle, sperm characteristics evaluation, and spontaneous and induced spawning methods have been described for wreckfish. Regarding nutrition, the positive effect of two types of enrichment on the fatty acid profiles of Artemia and rotifer has been verified. The relationship between the fatty acid profile of the diets supplied to the broodstock and the fatty acid profile obtained in the oocytes and eggs of the females fed with different diets, has also been demonstrated. Finally, early larval ontogeny has been described and incubation and larval rearing protocols have been proposed based on the results obtained in the different experiments of temperature, growth, survival, and larval feeding that were carried out.Versión del edito

Population-based multicase-control study in common tumors in Spain (MCC-Spain): rationale and study design

Introduction: We present the protocol of a large population-based case-control study of 5 common tumors in Spain (MCC-Spain) that evaluates environmental exposures and genetic factors. Methods: Between 2008-2013, 10,183 persons aged 20-85 years were enrolled in 23 hospitals and primary care centres in 12 Spanish provinces including 1,115 cases of a new diagnosis of prostate cancer, 1,750 of breast cancer, 2,171 of colorectal cancer, 492 of gastro-oesophageal cancer, 554 cases of chronic lymphocytic leukaemia (CLL) and 4,101 population-based controls matched by frequency to cases by age, sex and region of residence. Participation rates ranged from 57% (stomach cancer) to 87% (CLL cases) and from 30% to 77% in controls. Participants completed a face-to-face computerized interview on sociodemographic factors, environmental exposures, occupation, medication, lifestyle, and personal and family medical history. In addition, participants completed a self-administered food-frequency questionnaire and telephone interviews. Blood samples were collected from 76% of participants while saliva samples were collected in CLL cases and participants refusing blood extractions. Clinical information was recorded for cases and paraffin blocks and/or fresh tumor samples are available in most collaborating hospitals. Genotyping was done through an exome array enriched with genetic markers in specific pathways. Multiple analyses are planned to assess the association of environmental, personal and genetic risk factors for each tumor and to identify pleiotropic effects. Discussion: This study, conducted within the Spanish Consortium for Biomedical Research in Epidemiology & Public Health (CIBERESP), is a unique initiative to evaluate etiological factors for common cancers and will promote cancer research and prevention in Spain.The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT- 2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the The Catalan Government DURSI grant 2009SGR1489

Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition

Objective: To study the relationship between thalamic glucose metabolism and neurological outcome after severe traumatic brain injury (TBI). Methods: Forty-nine patients with severe and closed TBI and 10 healthy control subjects with 18F-FDG PET were studied. Patients were divided into three groups: MCS&VS group (n ¼ 17), patients in a vegetative or a minimally conscious state; In-PTA group (n ¼ 12), patients in a state of post-traumatic amnesia (PTA); and Out-PTA group (n ¼ 20), patients who had emerged from PTA. SPM5 software implemented in MATLAB 7 was used to determine the quantitative differences between patients and controls. FDG-PET images were spatially normalized and an automated thalamic ROI mask was generated. Group differences were analysed with two sample voxel-wise t-tests. Results: Thalamic hypometabolism was the most prominent in patients with low consciousness (MCS&VS group) and the thalamic hypometabolism in the In-PTA group was more prominent than that in the Out-PTA group. Healthy control subjects showed the greatest thalamic metabolism. These differences in metabolism were more pronounced in the internal regions of the thalamus. Conclusions: The results confirm the vulnerability of the thalamus to suffer the effect of the dynamic forces generated during a TBI. Patients with thalamic hypometabolism could represent a sub-set of subjects that are highly vulnerable to neurological disability after TBI.Lull Noguera, N.; Noé, E.; Lull Noguera, JJ.; Garcia Panach, J.; Chirivella, J.; Ferri, J.; López-Aznar, D.... (2010). Voxel-based statistical analysis of thalamic glucose metabolism in traumatic brain injury: relationship with consciousness and cognition. Brain Injury. 24(9):1098-1107. doi:10.3109/02699052.2010.494592S10981107249Gallagher, C. N., Hutchinson, P. J., & Pickard, J. D. (2007). Neuroimaging in trauma. Current Opinion in Neurology, 20(4), 403-409. doi:10.1097/wco.0b013e32821b987bWoischneck, D., Klein, S., Rei�berg, S., D�hring, W., Peters, B., & Firsching, R. (2001). Classification of Severe Head Injury Based on Magnetic Resonance Imaging. Acta Neurochirurgica, 143(3), 263-271. doi:10.1007/s007010170106Grados, M. A. (2001). Depth of lesion model in children and adolescents with moderate to severe traumatic brain injury: use of SPGR MRI to predict severity and outcome. Journal of Neurology, Neurosurgery & Psychiatry, 70(3), 350-358. doi:10.1136/jnnp.70.3.350Meythaler, J. M., Peduzzi, J. D., Eleftheriou, E., & Novack, T. A. (2001). Current concepts: Diffuse axonal injury–associated traumatic brain injury. Archives of Physical Medicine and Rehabilitation, 82(10), 1461-1471. doi:10.1053/apmr.2001.25137Scheid, R., Walther, K., Guthke, T., Preul, C., & von Cramon, D. Y. (2006). Cognitive Sequelae of Diffuse Axonal Injury. Archives of Neurology, 63(3), 418. doi:10.1001/archneur.63.3.418Brandstack, N., Kurki, T., Tenovuo, O., & Isoniemi, H. (2006). MR imaging of head trauma: Visibility of contusions and other intraparenchymal injuries in early and late stage. Brain Injury, 20(4), 409-416. doi:10.1080/02699050500487951Xu, J., Rasmussen, I.-A., Lagopoulos, J., & Håberg, A. (2007). Diffuse Axonal Injury in Severe Traumatic Brain Injury Visualized Using High-Resolution Diffusion Tensor Imaging. Journal of Neurotrauma, 24(5), 753-765. doi:10.1089/neu.2006.0208Levine, B., Fujiwara, E., O’connor, C., Richard, N., Kovacevic, N., Mandic, M., … Black, S. E. (2006). In Vivo Characterization of Traumatic Brain Injury Neuropathology with Structural and Functional Neuroimaging. Journal of Neurotrauma, 23(10), 1396-1411. doi:10.1089/neu.2006.23.1396Metting, Z., Rödiger, L. A., De Keyser, J., & van der Naalt, J. (2007). Structural and functional neuroimaging in mild-to-moderate head injury. The Lancet Neurology, 6(8), 699-710. doi:10.1016/s1474-4422(07)70191-6Nakayama, N. (2006). Relationship between regional cerebral metabolism and consciousness disturbance in traumatic diffuse brain injury without large focal lesions: an FDG-PET study with statistical parametric mapping analysis. Journal of Neurology, Neurosurgery & Psychiatry, 77(7), 856-862. doi:10.1136/jnnp.2005.080523Nakayama, N. (2006). Evidence for white matter disruption in traumatic brain injury without macroscopic lesions. Journal of Neurology, Neurosurgery & Psychiatry, 77(7), 850-855. doi:10.1136/jnnp.2005.077875O’Leary, D. D. M., Schlaggar, B. L., & Tuttle, R. (1994). Specification of Neocortical Areas and Thalamocortical Connections. Annual Review of Neuroscience, 17(1), 419-439. doi:10.1146/annurev.ne.17.030194.002223Mitelman, S. A., Byne, W., Kemether, E. M., Newmark, R. E., Hazlett, E. A., Haznedar, M. M., & Buchsbaum, M. S. (2006). Metabolic thalamocortical correlations during a verbal learning task and their comparison with correlations among regional volumes. Brain Research, 1114(1), 125-137. doi:10.1016/j.brainres.2006.07.043Laureys, S., Faymonville, M., Luxen, A., Lamy, M., Franck, G., & Maquet, P. (2000). Restoration of thalamocortical connectivity after recovery from persistent vegetative state. The Lancet, 355(9217), 1790-1791. doi:10.1016/s0140-6736(00)02271-6Laureys, S., Goldman, S., Phillips, C., Van Bogaert, P., Aerts, J., Luxen, A., … Maquet, P. (1999). Impaired Effective Cortical Connectivity in Vegetative State: Preliminary Investigation Using PET. NeuroImage, 9(4), 377-382. doi:10.1006/nimg.1998.0414Laureys, S., Owen, A. M., & Schiff, N. D. (2004). Brain function in coma, vegetative state, and related disorders. The Lancet Neurology, 3(9), 537-546. doi:10.1016/s1474-4422(04)00852-xGuye, M., Bartolomei, F., & Ranjeva, J.-P. (2008). Imaging structural and functional connectivity: towards a unified definition of human brain organization? Current Opinion in Neurology, 24(4), 393-403. doi:10.1097/wco.0b013e3283065cfbPrice, C. J., & Friston, K. J. (2002). Functional Imaging Studies of Neuropsychological Patients: Applications and Limitations. Neurocase, 8(5), 345-354. doi:10.1076/neur.8.4.345.16186Kim, J., Avants, B., Patel, S., Whyte, J., Coslett, B. H., Pluta, J., … Gee, J. C. (2008). Structural consequences of diffuse traumatic brain injury: A large deformation tensor-based morphometry study. NeuroImage, 39(3), 1014-1026. doi:10.1016/j.neuroimage.2007.10.005Maxwell, W. L., MacKinnon, M. A., Smith, D. H., McIntosh, T. K., & Graham, D. I. (2006). Thalamic Nuclei After Human Blunt Head Injury. Journal of Neuropathology & Experimental Neurology, 65(5), 478-488. doi:10.1097/01.jnen.0000229241.28619.75SIDAROS, A., SKIMMINGE, A., LIPTROT, M., SIDAROS, K., ENGBERG, A., HERNING, M., … ROSTRUP, E. (2009). Long-term global and regional brain volume changes following severe traumatic brain injury: A longitudinal study with clinical correlates. NeuroImage, 44(1), 1-8. doi:10.1016/j.neuroimage.2008.08.030Ashburner, J., & Friston, K. J. (2000). Voxel-Based Morphometry—The Methods. NeuroImage, 11(6), 805-821. doi:10.1006/nimg.2000.0582Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001). A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains. NeuroImage, 14(1), 21-36. doi:10.1006/nimg.2001.0786Giacino, J. T., Ashwal, S., Childs, N., Cranford, R., Jennett, B., Katz, D. I., … Zasler, N. D. (2002). The minimally conscious state: Definition and diagnostic criteria. Neurology, 58(3), 349-353. doi:10.1212/wnl.58.3.349Gispert, J. ., Pascau, J., Reig, S., Martínez-Lázaro, R., Molina, V., García-Barreno, P., & Desco, M. (2003). Influence of the normalization template on the outcome of statistical parametric mapping of PET scans. NeuroImage, 19(3), 601-612. doi:10.1016/s1053-8119(03)00072-7Ashburner, J., & Friston, K. J. (1999). Nonlinear spatial normalization using basis functions. Human Brain Mapping, 7(4), 254-266. doi:10.1002/(sici)1097-0193(1999)7:43.0.co;2-gTzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., … Joliot, M. (2002). Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain. NeuroImage, 15(1), 273-289. doi:10.1006/nimg.2001.0978Genovese, C. R., Lazar, N. A., & Nichols, T. (2002). Thresholding of Statistical Maps in Functional Neuroimaging Using the False Discovery Rate. NeuroImage, 15(4), 870-878. doi:10.1006/nimg.2001.1037LAUREYS, S., LEMAIRE, C., MAQUET, P., PHILLIPS, C., & FRANCK, G. (1999). Cerebral metabolism during vegetative state and after recovery to consciousness. Journal of Neurology, Neurosurgery & Psychiatry, 67(1), 121-122. doi:10.1136/jnnp.67.1.121Tommasino, C., Grana, C., Lucignani, G., Torri, G., & Fazio, F. (1995). Regional Cerebral Metabolism of Glucose in Comatose and Vegetative State Patients. Journal of Neurosurgical Anesthesiology, 7(2), 109-116. doi:10.1097/00008506-199504000-00006ANDERSON, C. V., WOOD, D.-M. G., BIGLER, E. D., & BLATTER, D. D. (1996). Lesion Volume, Injury Severity, and Thalamic Integrity following Head Injury. Journal of Neurotrauma, 13(2), 59-65. doi:10.1089/neu.1996.13.59Ge, Y., Patel, M. B., Chen, Q., Grossman, E. J., Zhang, K., Miles, L., … Grossman, R. I. (2009). Assessment of thalamic perfusion in patients with mild traumatic brain injury by true FISP arterial spin labelling MR imaging at 3T. Brain Injury, 23(7-8), 666-674. doi:10.1080/02699050903014899Uzan, M. (2003). Thalamic proton magnetic resonance spectroscopy in vegetative state induced by traumatic brain injury. Journal of Neurology, Neurosurgery & Psychiatry, 74(1), 33-38. doi:10.1136/jnnp.74.1.33OMMAYA, A. K., & GENNARELLI, T. A. (1974). CEREBRAL CONCUSSION AND TRAUMATIC UNCONSCIOUSNESS. Brain, 97(1), 633-654. doi:10.1093/brain/97.1.633Giacino, J., & Whyte, J. (2005). The Vegetative and Minimally Conscious States. Journal of Head Trauma Rehabilitation, 20(1), 30-50. doi:10.1097/00001199-200501000-00005Zeman, A. (2001). Consciousness. Brain, 124(7), 1263-1289. doi:10.1093/brain/124.7.1263Kinney, H. C., Korein, J., Panigrahy, A., Dikkes, P., & Goode, R. (1994). Neuropathological Findings in the Brain of Karen Ann Quinlan -- The Role of the Thalamus in the Persistent Vegetative State. New England Journal of Medicine, 330(21), 1469-1475. doi:10.1056/nejm199405263302101Saeeduddin Ahmed, Rex Bierley, Java. (2000). Post-traumatic amnesia after closed head injury: a review of the literature and some suggestions for further research. Brain Injury, 14(9), 765-780. doi:10.1080/026990500421886Wilson, J. T., Hadley, D. M., Wiedmann, K. D., & Teasdale, G. M. (1995). Neuropsychological consequences of two patterns of brain damage shown by MRI in survivors of severe head injury. Journal of Neurology, Neurosurgery & Psychiatry, 59(3), 328-331. doi:10.1136/jnnp.59.3.328Wilson, J. T., Teasdale, G. M., Hadley, D. M., Wiedmann, K. D., & Lang, D. (1994). Post-traumatic amnesia: still a valuable yardstick. Journal of Neurology, Neurosurgery & Psychiatry, 57(2), 198-201. doi:10.1136/jnnp.57.2.198Fearing, M. A., Bigler, E. D., Wilde, E. A., Johnson, J. L., Hunter, J. V., Xiaoqi Li, … Levin, H. S. (2008). Morphometric MRI Findings in the Thalamus and Brainstem in Children After Moderate to Severe Traumatic Brain Injury. Journal of Child Neurology, 23(7), 729-737. doi:10.1177/0883073808314159Little, D. M., Kraus, M. F., Joseph, J., Geary, E. K., Susmaras, T., Zhou, X. J., … Gorelick, P. B. (2010). Thalamic integrity underlies executive dysfunction in traumatic brain injury. Neurology, 74(7), 558-564. doi:10.1212/wnl.0b013e3181cff5d

Millorar la qualitat de la informació bibliogràfica en una biblioteca de campus: el cas de la Biblioteca Rector Gabriel Ferraté de la Universitat Politècnica de Catalunya

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Codisseny d’una eina web per fomentar les decisions compartides en persones amb esclerosi múltiple

Esclerosi múltiple; Tractament; Decisions compartides; Eines d'ajudaEsclerosis múltiple; Tratamiento; Decisiones compartidas; Herramientas de ayudaMultiple sclerosis; Treatment; Shared decisions; Help toolsPer apoderar les persones amb esclerosi múltiple en la gestió de la seva salut és essencial desenvolupar un lloc web i una eina de suport que permetin involucrar persones en la seva pròpia assistència sanitària i millorar la seva alfabetització en salut, promovent un model de presa de decisions compartit per a la selecció del tractament de l’esclerosi múltiple. L'article explica el desenvolupament del lloc web i l’eina de suport disponibles en accés obert a través de Canal Salut (http://decisionscompartides.gencat.cat/ca/inici/)

Foundations of youth work - Albemarle and after An analysis of the development of youth service policy at national level in England, 1958 to 1971

SIGLEAvailable from British Library Document Supply Centre-DSC:DX017291 / BLDSC - British Library Document Supply CentreGBUnited Kingdo