1 research outputs found
Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin
MarĂa Torres-DurĂĄn,1 JosĂ© Luis LĂłpez-Campos,2,3 Myriam Calle Rubio,4 Carmen Montero-MartĂnez,5 Ana Priegue Carrera,6 Rosanel Amaro RodrĂguez,7 Miriam Barrecheguren,8 MarĂa Ăngeles Barrio Guirado,9 Francisco Javier Callejas-GonzĂĄlez,10 Francisco Casas-Maldonado,11 Layla Diab-CĂĄceres,12 Pilar GarcĂa-Meseguer,9 JosĂ© MarĂa HernĂĄndez-PĂ©rez,13 Lourdes LĂĄzaro-Asegurado,14 Cristina MartĂnez-GonzĂĄlez,15 Carlos MartĂnez Rivera,16 Francisco Javier Michel,17 JosĂ©-Bruno Montoro-Ronsano,18 Raquel SĂĄnchez,19 Marta Ortiz-Pica,20 Isabel Parra,21 JosĂ© Pablo Quintero GarcĂa,22 MarĂa del Rosario Ruiz-Serrano-de la Espada,23 Begoña Tortajada-Goitia,24 Marc Miravitlles8 1Pneumology Department, Hospital Ălvaro Cunqueiro, NeumoVigo I+i Research Group, IIS Galicia Sur, Vigo, Spain; 2Instituto de Salud Carlos III, Centro de InvestigaciĂłn BiomĂ©dica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain; 3Medical and Surgery Unit for Respiratory Diseases, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del RocĂo/Universidad de Sevilla, Seville, Spain; 4Pneumology Department, Research Institute of Hospital ClĂnico San Carlos (IdISSC), Department of Medicine, Faculty of Medicine, University Complutense of Madrid, Madrid, Spain; 5Pneumology Department, Hospital Universitario de A Coruña, A Coruña, Spain; 6Nursing Unit, Hospital Ălvaro Cunqueiro, Pontevedra, Spain; 7Pneumology Department, Hospital ClĂnic, Barcelona, Spain; 8Pneumology Department, Hospital Universitari Vall dâHebron, Vall dâHebron Institut de Recerca (VHIR), Vall dâHebron Barcelona Hospital Campus, Barcelona, Spain; 9Nursung Unit, Hospital Universitari Vall dâHebron, Barcelona, Spain; 10Pneumology Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain; 11Pneumology Department, Hospital Universitario ClĂnico San Cecilio, Granada, Spain; 12Pneumology Department, Hospital Universitario 12 de Octubre, Madrid, Spain; 13Pneumology Department, Hospital Universitario Nuestra Señora de La Candelaria, Santa Cruz de Tenerife, Tenerife, Spain; 14Pneumology Department, Complejo Asistencial Universitario de Burgos, Burgos, Spain; 15Instituto de InvestigaciĂłn Sanitaria del Principado de Asturias (FINBA-ISPA) Oviedo, Oviedo, Spain; 16Pneumology Department, Hospital Universitario Germans TrĂas I Pujol, Institut dâinvestigaciĂł Germans Trias i Pujol (IGTP), Badalona, Spain; 17Pneumology Department, Hospital Universitario Donostia, Donostia, Spain; 18Hospital Pharmacy Department, Hospital Universitari Vall dâHebron, Vall dâHebron Barcelona Hospital Campus, Barcelona, Spain; 19Pneumology Department, Hospital Universitario Basurto, Bilbao, Spain; 20Nursing Unit, Hospital ClĂnico San Carlos, Madrid, Spain; 21Pneumology Department, Hospital ClĂnico Universitario Virgen de la Arrixaca, Murcia, Spain; 22Hospital Pharmacy Department, Hospital Universitario Virgen del RocĂo, Sevilla, Spain; 23Nursing Unit, Hospital Universitario Virgen del RocĂo, Sevilla, Spain; 24Hospital Pharmacy Department, Hospital Costa del Sol, MĂĄlaga, SpainCorrespondence: MarĂa Torres-DurĂĄn, Tel +34986811111, Email [email protected]: Administration of exogenous alpha-1 antitrypsin (AAT) is the only specific therapy for the management of pulmonary morbidity in patients with AAT deficiency. It requires weekly or biweekly intravenous infusions, which may impact patient independence and quality of life. Self-administration of AAT therapy is an alternative to reduce the burden for patients who require AAT therapy. We presented herein expertsâ recommendations for the implementation of a program for the self-administration of AAT.Methods: This project was conducted using a modified nominal group technique and was undertaken in two online meetings involving the participation of 25 experts: specialists in pulmonology (n=17), nurses (n=5) and hospital pharmacists (n=3).Results: The following issues were discussed, and several recommendations were agreed upon on the following topics: a) patient profile and clinical evaluation, establishing selection criteria that should include clinical as well as social criteria; b) role of health care professionals, suggested roles for specialists in pulmonology, nurses, and hospital pharmacists; c) training by the nurse, including recommendations before initiating the training and the content of the training sessions; and d) logistic issues and follow-up, adherence, and patient support.Conclusion: We expect this proposal to increase awareness of this therapeutic alternative and facilitate the implementation of self-administration programs, thus contributing to optimizing the patient experience with AAT therapy. Further research on the outcomes of these programs, especially from the patient perspective, will also help to improve their design and implementation.Keywords: alpha-1 antitrypsin deficiency, disease burden, augmentation therapy, self-administratio