Ballet and the Emotional Refocusing of Shakespeare

William Shakespeare\u27s works are most well-known on the stage in the form of a play. When the words at the heart of the story are removed and replaced with choreographed movement, it allows the audience to experience the stories, characters, and plots in a more emotionally focused manner. Ballet interpretations of some of Shakespeare\u27s most famous works are often taken on by world-renowned ballet companies, such as The Royal Ballet in London and The New York City Ballet. Companies and choreographers around the world are able to bring new light and depth to the emotional sides of these stories, giving more room to certain moments of the plot through dance that allow the audience to participate in a unique viewing of well-known texts. Looking at Shakespeare\u27s works through a lens which removes the written word and instead relies on movement and expression refocuses the familiar elements of the stories into an emotionally driven experience

Towards an Aesthetics of Auschwitz

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Forced Turnovers: Using Eminent Domain to Build Professional Sports Venues

If a city wants to keep a professional sports team within its borders, can that city use the power of eminent domain to do so? Although cities have not been able to successfully condemn the actual sports franchises within their respective cities, they have been successful in condemning land for the development of new sports venues intended to entice their teams to stay. In 2005, the City of Arlington, Texas invoked the power of eminent domain to condemn and destroy houses to make room for the Dallas Cowboys’ new stadium. In 2006, New York City used eminent domain on land belonging to private businesses in order to make room for construction of a new arena for the New Jersey Nets. Recently, three other major American cities (Sacramento, Atlanta, and Washington, D.C.) announced that they are prepared to use eminent domain to build new sports stadiums for their local professional sports teams. While there are a few strategies that property owners could hypothetically use to stop these takings, courts have yet to stop a city from using eminent domain to condemn land for sports stadiums. However, if property owners are willing to settle, these same strategies can help prolong condemnation negotiations, thereby increasing the owners’ potential remunerations

Acrolein inhibits respiration in isolated brain mitochondria

AbstractLipid peroxidation is elevated in diseased regions of brain in several neurodegenerative diseases. Acrolein (2-propenal) is a major cytotoxic product of lipid peroxidation and its adduction to neuronal proteins has been demonstrated in diseased brain regions from patients with Alzheimer’s disease. Mitochondrial abnormalities are implicated in several neurodegenerative disorders, and mitochondria are targets of alkenal adduction in vivo. We examined the effects of acrolein upon multiple endpoints associated with the mitochondrial involvement in neurodegenerative disease. Acrolein inhibited state 3 respiration with an IC50 of approx. 0.4 μmol/mg protein; however, there was no reduction in activity of complexes I–V. This inhibition was prevented by glutathione and N-acetylcysteine. Acrolein did not alter mitochondrial calcium transporter activity or induce cytochrome c release. These studies indicate that acrolein is a potent inhibitor of brain mitochondrial respiration

3D Printers

A preliminary report, addressing potential market disruption, the state of the law, and recommendations on future legislative action regarding consumer-grade 3D printing.https://digitalcommons.law.uw.edu/techclinic/1015/thumbnail.jp

Prostaglandin E(2 )receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein

BACKGROUND: The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute significantly to neurodegeneration in PD. It has been demonstrated that aggregated α-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated α-synuclein activates microglia are not understood fully. METHODS: We investigated the role of prostaglandin E(2 )receptor subtype 2 (EP2) in α-synuclein aggregation-induced microglial activation using ex vivo, in vivo and in vitro experimental systems. RESULTS: Results demonstrated that ablation of EP2(EP2(-/-)) significantly enhanced microglia-mediated ex vivo clearance of α-synuclein aggregates (from mesocortex of Lewy body disease patients) while significantly attenuating neurotoxicity and extent of α-synuclein aggregation in mice treated with a parkinsonian toxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Furthermore, we report that reduced neurotoxicity by EP2(-/- )microglia could be attributed to suppressed translocation of a critical cytoplasmic subunit (p47-phox) of NADPH oxidase (PHOX) to the membranous compartment after exposure to aggregated α-synuclein. CONCLUSION: Thus, it appears that microglial EP2 plays a critical role in α-synuclein-mediated neurotoxicity

Performance of business incubators: a systematic review of evidence

As a business incubator is located at the intersection of different actors (e. g. universities, governments, market), processes (e.g. entrepreneurship, innovation), micro and macro levels, investigate your performance is a great challenge for researchers. To understand what has already been done and the new paths to follow, here will be presented the state of the art of this topic in a systematic way. First, using bibliometric techniques. Second, analyzing the main contributions of the papers over the years. The results demonstrate an increase of interest in this topic, especially in the last 10 years. Using the tools of the Web of Science and some indexes (also suggesting a new one), relevant journals and routes for new research were identified. In addition to the greater presence of researchers from the United States of America (USA), Europe and Asia, it was also realized that many questions from the beginning continue today. The relationship with universities and research centers are great opportunities for further studies. Although network behavior is recognized as a relevant factor, many researches still present contradictory or ambiguous results. Delve deeper the dynamics of the incubation process, at each level of analysis, seems to be a more effective strategy for the research field progress.This work has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2013.info:eu-repo/semantics/publishedVersio