22 research outputs found
Positive Selection Results in Frequent Reversible Amino Acid Replacements in the G Protein Gene of Human Respiratory Syncytial Virus
Get PDFHuman respiratory syncytial virus (HRSV) is the major cause of lower respiratory tract infections in children under 5 years of age and the elderly, causing annual disease outbreaks during the fall and winter. Multiple lineages of the HRSVA and HRSVB serotypes co-circulate within a single outbreak and display a strongly temporal pattern of genetic variation, with a replacement of dominant genotypes occurring during consecutive years. In the present study we utilized phylogenetic methods to detect and map sites subject to adaptive evolution in the G protein of HRSVA and HRSVB. A total of 29 and 23 amino acid sites were found to be putatively positively selected in HRSVA and HRSVB, respectively. Several of these sites defined genotypes and lineages within genotypes in both groups, and correlated well with epitopes previously described in group A. Remarkably, 18 of these positively selected tended to revert in time to a previous codon state, producing a “flip-flop” phylogenetic pattern. Such frequent evolutionary reversals in HRSV are indicative of a combination of frequent positive selection, reflecting the changing immune status of the human population, and a limited repertoire of functionally viable amino acids at specific amino acid sites
“ Situazioni psicosociali anomale e disturbi psichiatrici in adolescenza: riflessioni sull’utilizzazione dell’Asse V dell’ICD 10”
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Il trattamento con tetraidrobiopterina (BH4) in pazienti responsivi affetti da deficit di fenilalanina idrossilasi
Full text linkLate-onset hereditary spastic paraplegia with thin corpus callosum caused by a new SPG3A mutation
Full text linkTHE TREATMENT OF PHENYLALANINE HYDROXYLASE (PAH)-DEFICIENT BH4-RESPONSIVE PATIENTS WITH TETRAHYDROBIOPTERIN (BH4): TOLERANCE TO PHE AND RESPONSE TO BH4
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Antenne integrate attive per terminali mobili ad alta efficienza
Full text link24nonenoneCOLANTONIO P; GIANNINI F; GIOFRÈ R; MONTIERI M.C; BACCARELLI P; BURGHIGNOLI P; FREZZA F; GALLI A; LAMPARIELLO P; PAULOTTO S; VALERIO G; VESCOVO R.; CAMARCHIA V; GHIONE G; NALDI C; PIROLA M; SANTARELLI A; CIGNANI R; FANTINI F; FLORIAN C; MANARA G; NEPA P; PELOSI G; SELLERI SColantonio, P; Giannini, F; Giofrè, R; MONTIERI M., C; Baccarelli, P; Burghignoli, P; Frezza, F; Galli, A; Lampariello, P; Paulotto, S; Valerio, G; Vescovo, Roberto; Camarchia, V; Ghione, G; Naldi, C; Pirola, M; Santarelli, A; Cignani, R; Fantini, F; Florian, C; Manara, G; Nepa, P; Pelosi, G; Selleri, S
Antenne integrate attive per terminali mobili ad alta efficienza
Full text linkL'obiettivo del lavoro è lo sviluppo di una Antenna Integrata Attiva (AIA Active Integrated Antenna) per terminali mobili ad alta efficienza in banda K
