On the Reaction of the Mammalian Lung to Trauma

1. Mouse and rat lungs punctured by cold sterile needles show local atelectasis with a transient and reversible swelling of the alveolar lining cells. No evidence of the injury can be seen, by naked-eye or microscopically, a week later. 2. Burns of lung produced by heated needles are organised from a boundary or demarcation zone of lung tissue and converted to functioning lung by the ingrowth of bronchial branches from pre-existing bronchi. 3. Excision of wedges of lung tissue in cats is followed by local scarring and the ultimate reformation of lung tissue in the scar. This process occurs through bronchial proliferation together with alveolar formation in the margins of the scar, processes which depend primarily on the active motility of the lung

Comments on \u27Fluctuations in Guiding Center Plasma in Two Dimensions\u27

It is stated that the principal result of the paper by Taylor and Thompson (see abstr. A14511 of 1973) on autocorrelations in density for the electrostatic guiding center plasma in two dimensions is wrong owing to an incorrect integration. It is further stated that there is no meaningful distinction between an `interaction cutoff\u27 and a `fluctuation cutoff\u27

The role of compressibility in solar wind plasma turbulence

Incompressible Magnetohydrodynamics is often assumed to describe solar wind turbulence. We use extended self similarity to reveal scaling in structure functions of density fluctuations in the solar wind. Obtained scaling is then compared with that found in the inertial range of quantities identified as passive scalars in other turbulent systems. We find that these are not coincident. This implies that either solar wind turbulence is compressible, or that straightforward comparison of structure functions does not adequately capture its inertial range properties.Comment: 4 pages, 7 figure

Nonlinear Alpha Effect in Dynamo Theory

We extend the standard two-scale theory of the turbulent dynamo coefficient $\alpha$ to include the nonlinear back reaction of the mean field $\bar B$ on the turbulence. We calculate the turbulent emf as a power series in $\bar B$, assuming that the base state of the turbulence ($\bar B=0$) is isotropic, and, for simplicity, that the magnetic diffusivity equals the kinematic viscosity. The power series converges for all $\bar B$, and for the special case that the spectrum of the turbulence is sharply peaked in $k$, our result is proportional to a tabulated function of the magnetic Reynolds number $R_M$ and the ratio $\beta$ of $\bar B$ (in velocity units) to the rms turbulent velocity $v_0$. For $\beta\to 0$ (linear regime) we recover the results of Steenbeck et al. (1966) as modified by Pouquet et al. (1976). For $R_M\gg 1$, the usual astrophysical case, $\alpha$ starts to decrease at $\beta \sim 1$, dropping like $\beta^{-2}$ as $\beta \to \infty$. Hence for large $R_M$, $\alpha$ saturates at $\bar B\sim v_0$, as estimated by Kraichnan (1979), rather than at $\bar B\sim R^{-1/2}_Mv_0$, as inferred by Cattaneo and Hughes (1996) from their numerical simulations at $R_M$=100. We plan to carry out simulations with various values of $R_M$ to investigate the discrepency.Comment: 41 pages, 1 Postscript figure, accepted for publication to Ap

Self-Reported Health-Promoting Behaviors of Black and White Caregivers

The purpose of this study was to describe the behaviors that caregivers report carrying out to maintain their own health, and to compare the health-promoting behaviors of Black and White caregivers. Although many studies have examined health-promoting behaviors, few have examined health promotion among caregivers. Reported studies of caregivers’ health-promoting behaviors have not compared cultural groups. The sample for this study was selected by random digit dialing, and included 136 Black and 257 White caregivers of frail elders. Content analysis of respondents’ answers to the open-ended question, “In general, what do you do to stay healthy?” was used to address the research questions. Most caregivers reported specific behaviors they engaged in for the purpose of staying healthy. Although most of their behaviors addressed physical health, caregivers also mentioned behaviors that contribute to mental and spiritual health. Both differences and similarities were found in Black and White caregivers’ self-reported health behaviors, which have important implications for nursing practice and research in the future.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69087/2/10.1177_01939459922044027.pd

An 18-month study of the safety and efficacy of repeated courses of inhaled aztreonam lysine in cystic fibrosis

Chronic airway infection with Pseudomonas aeruginosa (PA) causes morbidity and mortality in patients with cystic fibrosis (CF). Additional anti-PA therapies are needed to improve health status and health-related quality of life. AIR-CF3 was an international 18-month, open-label study to evaluate the safety and efficacy of repeated courses of aztreonam for inhalation solution (AZLI, now marketed as Cayston®) in patients aged ≥6 years with CF and PA infection who previously participated in one of two Phase 3 studies: AIR-CF1 or AIR-CF2. Patients received up to nine courses (28 days on/28 days off) of 75 mg AZLI two (BID) or three times daily (TID) based on randomization in the previous trials. 274 patients, mean age 28.5 years (range: 8–74 years), participated. Mean treatment adherence was high (92.0% BID group, 88.0% TID group). Hospitalization rates were low and adverse events were consistent with CF With each course of AZLI, FEV1 and scores on the Cystic Fibrosis Questionnaire-Revised Respiratory Symptomscale improved and bacterial density in sputum was reduced. Benefits waned in the 28 days off therapy, but weight gain was sustained over the 18months. There were no sustained decreases in PA susceptibility. A dose response was observed; AZLI TID-treated patients demonstrated greater improvements in lung function and respiratory symptoms over 18 months. Repeated intermittent 28-day courses of AZLI treatment were well tolerated. Clinical benefits in pulmonary function, health-related quality of life, and weight were observed with each course of therapy. AZLI is a safe and effective new therapy in patients with CF and PA airway infection

Measurements of the Temperature and E-Mode Polarization of the CMB from 500 Square Degrees of SPTpol Data

We present measurements of the $E$-mode polarization angular auto-power spectrum ($EE$) and temperature-$E$-mode cross-power spectrum ($TE$) of the cosmic microwave background (CMB) using 150 GHz data from three seasons of SPTpol observations. We report the power spectra over the spherical harmonic multipole range $50 < \ell \leq 8000$, and detect nine acoustic peaks in the $EE$ spectrum with high signal-to-noise ratio. These measurements are the most sensitive to date of the $EE$ and $TE$ power spectra at $\ell > 1050$ and $\ell > 1475$, respectively. The observations cover 500 deg$^2$, a fivefold increase in area compared to previous SPTpol analyses, which increases our sensitivity to the photon diffusion damping tail of the CMB power spectra enabling tighter constraints on \LCDM model extensions. After masking all sources with unpolarized flux $>50$ mJy we place a 95% confidence upper limit on residual polarized point-source power of $D_\ell = \ell(\ell+1)C_\ell/2\pi <0.107\,\mu{\rm K}^2$ at $\ell=3000$, suggesting that the $EE$ damping tail dominates foregrounds to at least $\ell = 4050$ with modest source masking. We find that the SPTpol dataset is in mild tension with the $\Lambda CDM$ model ($2.1\,\sigma$), and different data splits prefer parameter values that differ at the $\sim 1\,\sigma$ level. When fitting SPTpol data at $\ell < 1000$ we find cosmological parameter constraints consistent with those for $Planck$ temperature. Including SPTpol data at $\ell > 1000$ results in a preference for a higher value of the expansion rate (H_0 = 71.3 \pm 2.1\,\mbox{km}\,s^{-1}\mbox{Mpc}^{-1} ) and a lower value for present-day density fluctuations ($\sigma_8 = 0.77 \pm 0.02$).Comment: Updated to match version accepted to ApJ. 34 pages, 17 figures, 6 table

Performance and on-sky optical characterization of the SPTpol instrument

In January 2012, the 10m South Pole Telescope (SPT) was equipped with a polarization-sensitive camera, SPTpol, in order to measure the polarization anisotropy of the cosmic microwave background (CMB). Measurements of the polarization of the CMB at small angular scales (~several arcminutes) can detect the gravitational lensing of the CMB by large scale structure and constrain the sum of the neutrino masses. At large angular scales (~few degrees) CMB measurements can constrain the energy scale of Inflation. SPTpol is a two-color mm-wave camera that consists of 180 polarimeters at 90 GHz and 588 polarimeters at 150 GHz, with each polarimeter consisting of a dual transition edge sensor (TES) bolometers. The full complement of 150 GHz detectors consists of 7 arrays of 84 ortho-mode transducers (OMTs) that are stripline coupled to two TES detectors per OMT, developed by the TRUCE collaboration and fabricated at NIST. Each 90 GHz pixel consists of two antenna-coupled absorbers coupled to two TES detectors, developed with Argonne National Labs. The 1536 total detectors are read out with digital frequency-domain multiplexing (DfMUX). The SPTpol deployment represents the first on-sky tests of both of these detector technologies, and is one of the first deployed instruments using DfMUX readout technology. We present the details of the design, commissioning, deployment, on-sky optical characterization and detector performance of the complete SPTpol focal plane.Comment: 15 pages, 6 figures. Conference: SPIE Astronomical Telescopes and Instrumentation 201

Design and characterization of 90 GHz feedhorn-coupled TES polarimeter pixels in the SPTpol camera

The SPTpol camera is a two-color, polarization-sensitive bolometer receiver, and was installed on the 10 meter South Pole Telescope in January 2012. SPTpol is designed to study the faint polarization signals in the Cosmic Microwave Background, with two primary scientific goals. One is to constrain the tensor-to-scalar ratio of perturbations in the primordial plasma, and thus constrain the space of permissible inflationary models. The other is to measure the weak lensing effect of large-scale structure on CMB polarization, which can be used to constrain the sum of neutrino masses as well as other growth-related parameters. The SPTpol focal plane consists of seven 84-element monolithic arrays of 150 GHz pixels (588 total) and 180 individual 90 GHz single-pixel modules. In this paper we present the design and characterization of the 90 GHz modules