Quantitative analysis of a footwall‐scarp degradation complex and syn‐rift stratigraphic architecture, Exmouth Plateau, NW Shelf, offshore Australia

Interactions between footwall‐, hangingwall‐ and axial‐derived depositional systems make syn‐rift stratigraphic architecture difficult to predict, and preservation of net‐erosional source landscapes is limited. Distinguishing between deposits derived from fault‐scarp degradation (consequent systems) and those derived from long‐lived catchments beyond the fault block crest (antecedent systems) is also challenging, but important for hydrocarbon reservoir prospecting. We undertake geometric and volumetric analysis of a fault‐scarp degradation complex and adjacent hangingwall‐fill associated with the Thebe‐2 fault block on the Exmouth Plateau, NW Shelf, offshore Australia, using high resolution 3D seismic data. Vertical and headward erosion of the complex and fault throw are measured. Seismic‐stratigraphic and seismic facies mapping allow us to constrain the spatial and architectural variability of depositional systems in the hangingwall. Footwall‐derived systems interacted with hangingwall‐ and axial‐derived systems, through diversion around topography, interfingering or successive onlap. We calculate the volume of footwall‐sourced hangingwall fans (VHW) for nine quadrants along the fault block, and compare this to the volume of material eroded from the immediately up‐dip fault‐scarp (VFW). This analysis highlights areas of sediment bypass (VFW > VHW) and areas fed by sediment sources beyond the degraded fault scarp (VHW > VFW). Exposure of the border fault footwall and adjacent fault terraces produced small catchments located beyond the fault block crest that fed the hangingwall basin. One source persisted throughout the main syn‐rift episode, and its location coincided with: (a) an intra‐basin topographic high; (b) a local fault throw minimum; (c) increased vertical and headward erosion within the fault‐scarp degradation complex; and (d) sustained clinoform development in the immediate hangingwall. Our novel quantitative volumetric approach to identify through‐going sediment input points could be applied to other rift basin‐fills. We highlight implications for hydrocarbon exploration and emphasize the need to incorporate interaction of multiple sediment sources and their resultant architecture in tectono‐stratigraphic models for rift basins

Homer's Odyssey, books XIII-XXIV;

Mode of access: Internet

Synthetic diversi\ufb01cation of natural products : semi-synthesis and evaluation of triazole jadomycins

Growth of Streptomyces venezuelae ISP5230 with O-propargyl-L-serine led to the ef\ufb01cient production of an alkyne-containing jadomycin. The installed alkyne functionality provided a uniquely reactive handle within the natural product and was subsequently reacted with a series of azides to afford an eight-member library of jadomycin triazoles. The compounds were evaluated for their DNA cleavage, antibacterial and cytotoxic properties.Peer reviewed: YesNRC publication: Ye

Jadomycins Derived from the Assimilation and Incorporation of Norvaline and Norleucine

<i>Streptomyces venezuelae</i> ISP5230 is recognized for the production of chloramphenicol and the jadomycin family of natural products. The jadomycins are angucycline natural products containing a unique oxazolone ring incorporating an amino acid present in the minimal culture media. Substitution of different amino acids results in products of varying biological activity. Analysis of cultures of <i>S. venezuelae</i> ISP5230 incubated with l- and d-norvaline and l- and d-norleucine indicated that only the d-configured amino acids were incorporated into the natural products. Subsequently, jadomycin DNV and jadomycin DNL were isolated and characterized (titers 4 and 9 mg L^–1, respectively). The compounds were evaluated in the National Cancer Institute cell line cancer growth inhibition and cytotoxicity screens, for antimicrobial activity against selected Gram-positive and Gram-negative bacteria, and as DNA-cleavage agents <i>in vitro</i>

Self-interest in the thought of Adam Ferguson

Adam Ferguson (1723–1816) was a prominent member of the Scottish Enlightenment. His most famous work An Essay on the History of Civil Society (1767) has often been read as a dissenting voice from the positive view of commerce found in the work of his friends Adam Smith and David Hume. Readings of Ferguson tend to focus on the Essay and to see him as either a civic republican worried about the impact of commerce on citizenship, or as a precursor to Marxian ideas of alienation and the anti-social impact of economic development. This paper argues against both of these interpretations, and against the practice of reading Ferguson through the Essay alone. Taking his discussion of self-interest as its focus, the paper shows how, in Ferguson’s other writings, he develops a complex and nuanced understanding of the place of self-interest in moral and political life. Central to this is Ferguson’s concept of ambition: an idea crucial to his moral philosophy and one which places Ferguson at the heart of eighteenth century debates about the nature of self-regarding behaviour