5 research outputs found
Neuroendocrine Carcinoma of the Breast – Real versus Mimic
Primary neuroendocrine carcinoma of the breast is a
rare entity and is difcult to differentiate from invasive
ductal carcinoma with neuroendocrine differentiation
especially on small core biopsy specimens. Here we
present one such challenging case of a 69 years old
female who presented with invasive ductal carcinoma
of the breast with neuroendocrine differentiation. The
biopsy specimen showed predominately invasive high
grade tumor staining for neuroendocrine markers and
negative cytokeratin markers, supporting a diagnosis
of neuroendocrine carcinoma. Follow up mastectomy
showed in situ and invasive ductal carcinoma with
neuroendocrine differentiation. This case highlights
the challenges of differentiating between these closely
similar entities with overlapping features. Clinical
history, thorough morphological examination and
immunohistochemistry are needed to accurately
classify these tumors as the treatment and prognosis
vary signicantly