High Vascular Invasion Signature score is associated with reduced recurrence free survival.

<p>High signature score is associated with reduced recurrence free survival in data sets GSE1456, GSE2506 and GSE20685. In data set GSE7849, there is a trend between high signature score and reduced recurrence free survival. Survival curves are estimated by the Kaplan-Meier method (log-rank significance test). For each category, the number of cases is given followed by the number of breast cancer deaths.</p

Association between the 18-gene signature score and response to treatment (mean signature score is given).

1<p>Near-complete pathologic response,</p>2<p>Pathologic complete response,</p>3<p>No response,</p>4<p>Partial respons,</p>5<p>Mann-Whitney U test,</p>6<p>Residual disease.</p

Multivariate survival analysis (Cox' proportional hazards regression model) of the vascular invasion signature score.

1<p>Adjusted Hazard ratio,</p>2<p>95% confidence interval,</p>3<p>Lratio test, Final model after inclusion of: ⁴Vascular invasion score, histologic grade and molecular subtype or ⁵Vascular invasion score and molecular subtype.</p><p>Data presented for disease specific survival, overall survival and recurrence free survival.</p

Associations between ER-status, PR-status, HER2-status and the 18-gene vascular invasion signature score (mean signature score is given).

1<p>Mann-Whitney U test, significance level 0.05.</p

High Vascular Invasion Signature score is associated with reduced survival.

<p>High signature score is associated with reduced survival in datasets GSE1456 and GSE20685. Univariate survival analysis was performed by the Kaplan-Meier method (log-rank significance test). For each category, the number of cases is given followed by the number of breast cancer deaths.</p

High Vascular Invasion Signature score is associated with Basal-like and HER2 molecular subtypes.

<p>High signature score is associated with Basal-like and HER2 molecular subtypes among data sets GSE25066, GSE22358, GSE1456 and GSE20685. Correlations were assessed by Kruskal-Wallis test. Mean expression signature scores indicated by circles, and the bars represent standard error ±2.</p

The vascular invasion signature consists of 7 up-regulated and 11 down-regulated genes [5].

<p>The vascular invasion signature consists of 7 up-regulated and 11 down-regulated genes <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0098787#pone.0098787-Mannelqvist2" target="_blank">[5]</a>.</p