The Contribution of Outdoor Fine Particulate Matter to Indoor Air Quality in Bangkok Metropolitan Region, Thailand – Are Indoor Dwellers Safe?

Objective: This study aimed to analyze the relationship between indoor and outdoor fine particulate matter (PM2.5) concentrations and to characterize factors that may contribute to domestic PM2.5 concentrations, including smoking, printer/copier, and cooking activities. Methods: We measured the ambient and indoor PM2.5 concentrations from 7 sampling sites in Bangkok Metropolitan and vicinity area, Thailand by using PM2.5 concentrations sensor (SN-GCHA1, Panasonic Photo & Lighting Co., Ltd). Real-time PM2.5 concentrations, temperature, and relative humidity (RH) measurements were recorded hourly for two consecutive days during February 20th to March 2nd, 2018. We collected real-time indoor and outdoor PM2.5 mass concentrations at the same time. Factors influencing domestic PM2.5 production in the indoor environment were recorded. Results: The mean indoor PM2.5 concentrations from each site ranged from 20.05-45.85 μg/m3 and the mean outdoor PM2.5 concentrations ranged from 9.42-56.56 μg/m3. The ambient and indoor PM2.5 mass concentrations curves tended to fluctuate in a similar trend. There was a significantly positive correlation between the average ambient and the average indoor PM2.5 mass concentrations in all studied places. The correlation coefficient (r) varied from 0.6 to 0.833. Five from seven sites demonstrated a strong correlation (r ≥ 0.7), whereas, two from seven sites demonstrated a moderate correlation (0.5 ≤ r < 0.7). The average indoor/ambient PM2.5 concentration ratio from each place ranged from 0.37 to 3.57. Conclusion: The indoor PM2.5 concentrations are correlated with the ambient PM2.5 concentrations. The concentrations of PM2.5 in most sampling sites were higher than the recommended threshold. Hence, indoor dwellers are still at risk for health impacts from PM2.5. Besides public management of the ambient PM2.5, the interventions dealing with the indoor PM2.5 should be promoted concurrently

How Microbiomes Affect Skin Aging: The Updated Evidence and Current Perspectives

The skin has a multifactorial aging process, caused by both intrinsic and extrinsic factors. A major theory of aging involves cellular senescence or apoptosis resulting from oxidative damage as the skin&rsquo;s antioxidant system tends to weaken with age. The human microbiota is a complex ecosystem that is made up of microorganisms (bacteria, fungi, and viruses). Both gut and skin microbiota have essential roles in the protection against invading pathogens, mediating inflammatory conditions, and the modulation of the immune system which is involved in both innate and adaptive immune responses. However, the human microbiome could be changed during the life stage and affected by various perturbations. An alteration of the intestinal bacteria results in &ldquo;microbial dysbiosis&rdquo; which is associated with the influence of various diseases, including aging. The skin interactome is a novel integration of the &ldquo;genome-microbiome-exposome&rdquo; that plays a significant role in skin aging and skin health. Mitigating the negative impacts of factors influencing the skin interactome should be the future strategy to protect, prevent, and delay skin aging along with preserving healthy skin conditions. This review summarizes the current evidence on how human microbiomes affect skin aging and demonstrates the possible interventions, relating to human microbiomes, to modulate skin health and aging. Probiotics-based products are currently available mainly for the add-on treatment of many dermatologic conditions. However, at this point, there are limited clinical studies on skin anti-aging purposes and more are required as this evolving concept is on the rise and might provide an insight into future therapeutic options

Revisiting Fruit Allergy: Prevalence across the Globe, Diagnosis, and Current Management

Fruit allergies manifest with a diverse array of clinical presentations, ranging from localized contact allergies and oral allergy syndrome to the potential for severe systemic reactions including anaphylaxis. The scope of population-level prevalence studies remains limited, largely derived from single-center or hospital-based investigations. In this comprehensive review, we conducted a systematic literature search spanning the years 2009 to 2023, with full acknowledgment of potential analytical biases, to provide a global overview of fruit allergy prevalence. The primary mechanistic underpinning of fruit allergies stems from cross-reactivity between aeroallergens and food allergens, a consequence of structurally similar epitopes—a phenomenon recognized as pollen food allergy syndrome (PFAS). In the era of molecular allergology, numerous studies have dissected allergen components with substantial clinical relevance. Within this review, we explore important allergenic molecules found in plant-based foods, scrutinize pertinent cross-reactivity patterns, and offer insights into management recommendations. Additionally, we compare guideline recommendations to enhance clinical understanding and inform decision making

Severe anaphylaxis after pelvic examination: a case report of dual latex and chlorhexidine allergies

Abstract Background Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of dual latex and chlorhexidine allergies which caused anaphylaxis after pelvic examination in a woman with a history of latex-related fruits allergy. Case presentation A 54-year-old woman had severe anaphylaxis after a pelvic examination due to dual latex and chlorhexidine (CHX) allergies. The gynecologist used CHX for the vaginal preparation and wore latex-containing gloves with lubricating gel during the examination. In vivo and in vitro tests revealed CHX sensitization by a positive skin prick test to chlorhexidine at a very low concentration (0.002 mg/mL), and a positive basophil activation test to CHX. Latex allergy was confirmed by a positive specific IgE to latex and a positive glove-use test at 20 min. An analysis of specific IgE to latex component revealed positive results for Hev b 1, 5, 6.02, and 11. As she also had a past history of fruit allergy, prick-to-prick testing with latex-related fruits was performed. The results were positive for avocado, banana, jackfruit, kiwi, and longan. Conclusions Concomitant mucosal exposure of both natural rubber latex and CHX in highly sensitized patients during pelvic examinations can lead to severe anaphylaxis. Pre-procedural screening for an allergy to latex or CHX, or to any other allergen, should be performed in patients where there is suspicion of a specific allergy due to a previous allergic reaction. Increased awareness of these two allergens in all healthcare settings may improve patient safety

Dose-Dependent Blood-Feeding Activity and Ovarian Alterations to PM2.5 in Aedes aegypti

High levels of fine particulate matter (PM2.5) air pollution are a concern for human health. Several studies have examined the effects of air pollution on human and animal health. However, there is a lack of knowledge about its effects on arbovirus vectors. Thus, we investigated whether PM2.5 concentration alters the blood-feeding activity of Ae. aegypti mosquitoes. We investigated the effect on the females’ propensity to blood feed at eight concentrations of PM2.5 ranging from 100 to 1000 μg/m3. Correlation analysis showed blood-feeding activity had a significant strong negative correlation with concentration of PM2.5 (rp = −0.85; p ≤ 0.00001). Exploratory linear and non-linear models showed an exponential decay relationship was the best fitting model (corrected Akaike’s information criterion, 193.0; Akaike’s weight, 0.766; adjusted R2, 0.780). Ultrastructural study demonstrated PM2.5 did not obstruct the respiratory system, but some fine particles were present on the antenna and abdominal body parts. Ovaries showed a dose–response relationship between PM2.5 level and vacuolated degeneration. In conclusion, the blood-feeding behavior of Ae. aegypti females may have an exponential decay relationship with PM2.5 level, and their ovaries may demonstrate dose-dependent degeneration. These findings may be important in understanding the vector’s biology and disease transmission in settings with high PM2.5 levels. These results are important to understand blood-feeding and feeding pattern of mosquitoes during PM2.5 pollution, which is important for disease transmission and vector control

Genetic Association of Beta-Lactams-Induced Hypersensitivity Reactions: A Protocol for Systematic Review and Meta-Analysis

Beta-lactam (BL) antibiotics are among the drugs commonly related to hypersensitivity reactions. Several candidate gene studies and genome-wide association studies have reported associations of genetic variants and hypersensitivity reactions induced by BL antibiotics. However, the results were inconclusive. This protocol details a comprehensive systematic review of genetic factors associated with BL-induced hypersensitivity. A systematic search of literature related to genetic associations of BL-induced hypersensitivity will be performed through PubMed, Medline, Scopus, EMBASE, Web of Science, CINAHL, and the Cochrane central register of Controlled Trials (CENTRAL) from their inception dates with no language restrictions. Two reviewers will independently screen, extract, and appraise the risk of bias. Frequencies of genetic variants that comply with Hardy–Weinberg equilibrium will be extracted and pooled. Genetic models will be applied to variant effect calculation as per allele and genotype analysis. Based on statistical heterogeneity among studies, common effect estimation (odds ratio) and its corresponding 95% confidence interval will be analyzed. Sensitivity and subgroup analyses will be performed to determine the robustness of eligible studies. This systematic review and meta-analysis will provide comprehensive evidence of genetic effects regarding BL-induced hypersensitivity. The findings will enlighten the determination of disease-related genotypes that would potentially reveal allergy profiling in patients

Genetic Association of Beta-Lactams-Induced Hypersensitivity Reactions: A Protocol for Systematic Review and Meta-Analysis

Beta-lactam (BL) antibiotics are among the drugs commonly related to hypersensitivity reactions. Several candidate gene studies and genome-wide association studies have reported associations of genetic variants and hypersensitivity reactions induced by BL antibiotics. However, the results were inconclusive. This protocol details a comprehensive systematic review of genetic factors associated with BL-induced hypersensitivity. A systematic search of literature related to genetic associations of BL-induced hypersensitivity will be performed through PubMed, Medline, Scopus, EMBASE, Web of Science, CINAHL, and the Cochrane central register of Controlled Trials (CENTRAL) from their inception dates with no language restrictions. Two reviewers will independently screen, extract, and appraise the risk of bias. Frequencies of genetic variants that comply with Hardy&ndash;Weinberg equilibrium will be extracted and pooled. Genetic models will be applied to variant effect calculation as per allele and genotype analysis. Based on statistical heterogeneity among studies, common effect estimation (odds ratio) and its corresponding 95% confidence interval will be analyzed. Sensitivity and subgroup analyses will be performed to determine the robustness of eligible studies. This systematic review and meta-analysis will provide comprehensive evidence of genetic effects regarding BL-induced hypersensitivity. The findings will enlighten the determination of disease-related genotypes that would potentially reveal allergy profiling in patients