Inhibition the mutagenicity of vitamin a by using Olea europaea extract

This study aims to investigate the predisposition of the extraction of the extract of olive leaves (Olea europaea of the family Oleaceae, or the olive family) to frustrate the excretion of the inherent toxic caused by vitamin A (henceforth VA). After being sure that the extraction is inane of any negative effects on the living creature, the following tests are adopted, the mitotic index test of the medulla ossium of the bones, and the chromosomal aberration test. The results showed that toxic dose of vitamin A have cytogenetic effect. It cusses increased in bone marrow cell proliferation and increase in chromosome malformation, the olea leaf extract showed anti-mutagenic activity against the cytogenetic effect of vitamin A it decrees chromosome malformation and kept the Mitotic index in normal level