Boschini e il restauro, fra tutela e mercato

Il contributo individua sulla base degli scritti boschiniani le posizioni tenute dall'autore rispetto al problema della tutela e del restauro delle opere d'arte nella Venezia del Seicento, al contempo evidenziando le distinzioni correnti fra il concetto di restauro come recupero e restauro commerciale e facendo emergere diverse figure di artisti a vario titolo coinvolte nella questione

Con ogni \uabtipografica accuratezza\ubb: note attorno al ritratto di Giovambattista Spolverini nell\u2019edizione Giuliari della "Coltivazione del riso"

L\u2019uscita nel 1796 presso la tipografia Giuliari della terza edizione della "Coltivazione del riso" di Giovambattista Spolverini coincide con l\u2019avvio di un risarcimento delle fortune del poema che procede di pari passo con la divulgazione dell\u2019effigie del marchese, il cui ritratto disegnato da Agostino Ugolini e inciso da Andrea de\u2019 Bernardis ornava l\u2019antiporta del volume. L\u2019immagine era stata desunta da un prototipo pittorico posseduto dalla figlia dell\u2019autore, la cui acquisizione e circolazione appaiono regolate da meccanismi di familiarit\ue0 inequivocabilmente riconducibili all\u2019esistenza di circuiti dinastici e sodali determinanti rispetto all\u2019organizzazione del mercato dell\u2019arte scaligero. D\u2019altro canto, le sue numerose derivazioni, fra cui le incisioni del Rados (1818) e di Musitelli (1824), appaiono emblematiche del fin quui sfuggito protrarsi nell\u2019Ottocento dell\u2019apprezzamento postumo di cui godr\ue0 lo Spolverini, la cui immagine finir\ue0 per essere assunta di diritto entro imprese celebrative di altissimo rilievo, quali il \u201cPanteon veneto\u201d allestito in Palazzo Ducale a Venezia e la successiva Protomoteca veronese

"Santa Francesca Romana e l\u2019angelo": storia e conservazione della pala di Guercino in Santa Maria in Organo a Verona

Il saggio ripercorre le vicende che portarono gli olivetani della chiesa veronese di Santa Maria in Organo ad acquisire la pala del Guercino con "Santa Francesca Romana e l'angelo", inquadrando la medesima nel contesto pi\uf9 generale della produzione del centese e al contempo approfondendo le implicazioni iconografiche del dipinto. Sulla base di documentazione inedita il contributo ripercorre inoltre le complesse vicende conservative della tela, con particolare attenzione agli interventi ottocenteschi, riconsiderati anche attraverso una campagna di indagini non invasive appositamente effettuata e di cui nel medesimo volume d\ue0 conto il saggio di Paola Arton

Governing through security? Institutional discourse, practices, and policies in the metropolitan city of Milan

In our paper, we aim at pointing out the way the most relevant institutional actors currently define the security agenda for the Milanese metropolitan area, which kind of goals they try to pursue, upon which instruments and resources they can rely, which division of labour and forms of cooperation they try to putting into practices. We draw from an analyses of both official documents by the main public institutions involved in the governance of security in Milan and semi-structured interviews to all the members of the Comitato provinciale per l’ordine pubblico e la sicurezza – a board that gather the president of the province, the mayor of the province capital (plus mayors of other cities and towns of the province who can be involved on an ad hoc basis), the representative of the Ministry of Internal Affairs (Prefetto), the District Attorney and the chiefs of all the national police forces – as well as to politicians, civil servants and commissioners of the local police of the city of Milan. We illustrate how discourses and practices of in/security have contributed to the construction of the city as place exposed to a multiplicity of risks that local authorities and police forces are expected to manage. Furthermore, we highlight how the diffusion and legitimization of an ‘ideology of safety’ has turned the demand to live in safe communities into an attempt to legitimize exclusionary practices insofar as discourses on security were strictly interconnected with discourses on cultural identity and, focusing on both the (imagined) community repertoire and the us/them opposition, ended up legitimizing a racialized urban governance of inclusion and exclusion. Finally, we try to show that a recent attempt, by the new centre-left government, to modify such an approach is generating ambiguous and controversial results and is paradoxically promoting an even stronger securitization of urban policies, spaces and life through more democratically oriented governmental practices

A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression

Toll-like receptors (TLRs) function as primary sensors that elicit coordinated innate immune defenses through recognition of microbial products and induction of immune and proinflammatory genes. Here we report the identification and biological characterization of a lipopolysaccharide (LPS)-like molecule extracted from the cyanobacterium Oscillatoria Planktothrix FP1 (cyanobacterial product [CyP]) that is not stimulatory per se but acts as a potent and selective antagonist of bacterial LPS. CyP binds to MD-2 and efficiently competes with LPS for binding to the TLR4–MD-2 receptor complex. The addition of CyP together with LPS completely inhibited both MyD88- and TRIF-dependent pathways and suppressed the whole LPS-induced gene transcription program in human dendritic cells (DCs). CyP protected mice from endotoxin shock in spite of a lower capacity to inhibit LPS stimulation of mouse DCs. Interestingly, the delayed addition of CyP to DCs responding to LPS strongly inhibited signaling and cytokine production by immediate down-regulation of inflammatory cytokine mRNAs while not affecting other aspects of DC maturation, such as expression of major histocompatibility complex molecules, costimulatory molecules, and CCR7. Collectively, these results indicate that CyP is a potent competitive inhibitor of LPS in vitro and in vivo and reveal the requirement of sustained TLR4 stimulation for induction of cytokine genes in human DCs

COMT Val158Met polymorphism and socioeconomic status interact to predict attention deficit/hyperactivity problems in children aged 10–14

The functional Val158Met COMT polymorphism appears to affect a host of behaviours mediated by the pre-frontal cortex, and has been found associated to the risk for disruptive behaviours including ADHD. Parental socioeconomic status (SES) has also been reported as a predictor for the same childhood disorders. In a general population sample of 575 Italian pre-adolescents aged 10–14, we examined the association of the functional Val158Met COMT polymorphism and SES—both as linear and interactive effects—with oppositional defiant problems, conduct problems, and attention deficit/hyperactivity problems, as defined by the newly established Child Behaviour Check-List/6-18 DSM oriented scales. Multivariate- and subsequent univariate-analysis of covariance showed a significant association of COMT × SES interaction with CBCL 6/18 DOS attention deficit/hyperactivity problems (p = 0.004), and revealed higher scores among those children with Val/Val COMT genotype who belonged to low-SES families. We also found a significant association of SES with attention deficit/hyperactivity problems and conduct problems DOS (p = 0.04 and 0.01, respectively). Our data are consistent with a bulk of recent literature suggesting a role of environmental factors in moderating the contribution of specific genetic polymorphisms to human variability in ADHD. While future investigations will refine and better clarify which specific environmental and genetic mechanisms are at work in influencing the individual risk to ADHD in pre-adolescence, these data may contribute to identify/prevent the risk for ADHD problems in childhood

Spatio-temporal modelling of routine health facility data for malaria risk micro-stratification in mainland Tanzania

As malaria transmission declines, the need to monitor the heterogeneity of malaria risk at finer scales becomes critical to guide community-based targeted interventions. Although routine health facility (HF) data can provide epidemiological evidence at high spatial and temporal resolution, its incomplete nature of information can result in lower administrative units without empirical data. To overcome geographic sparsity of data and its representativeness, geo-spatial models can leverage routine information to predict risk in un-represented areas as well as estimate uncertainty of predictions. Here, a Bayesian spatio-temporal model was applied on malaria test positivity rate (TPR) data for the period 2017-2019 to predict risks at the ward level, the lowest decision-making unit in mainland Tanzania. To quantify the associated uncertainty, the probability of malaria TPR exceeding programmatic threshold was estimated. Results showed a marked spatial heterogeneity in malaria TPR across wards. 17.7 million people resided in areas where malaria TPR was high (≥ 30; 90% certainty) in the North-West and South-East parts of Tanzania. Approximately 11.7 million people lived in areas where malaria TPR was very low (< 5%; 90% certainty). HF data can be used to identify different epidemiological strata and guide malaria interventions at micro-planning units in Tanzania. These data, however, are imperfect in many settings in Africa and often require application of geo-spatial modelling techniques for estimation

The use of routine health facility data for micro-stratification of malaria risk in mainland Tanzania

Background Current efforts to estimate the spatially diverse malaria burden in malaria-endemic countries largely involve the use of epidemiological modelling methods for describing temporal and spatial heterogeneity using sparse interpolated prevalence data from periodic cross-sectional surveys. However, more malaria-endemic countries are beginning to consider local routine data for this purpose. Nevertheless, routine information from health facilities (HFs) remains widely under-utilized despite improved data quality, including increased access to diagnostic testing and the adoption of the electronic District Health Information System (DHIS2). This paper describes the process undertaken in mainland Tanzania using routine data to develop a high-resolution, micro-stratification risk map to guide future malaria control efforts. Methods Combinations of various routine malariometric indicators collected from 7098 HFs were assembled across 3065 wards of mainland Tanzania for the period 2017–2019. The reported council-level prevalence classification in school children aged 5–16 years (PfPR5–16) was used as a benchmark to define four malaria risk groups. These groups were subsequently used to derive cut-offs for the routine indicators by minimizing misclassifications and maximizing overall agreement. The derived-cutoffs were converted into numbered scores and summed across the three indicators to allocate wards into their overall risk stratum. Results Of 3065 wards, 353 were assigned to the very low strata (10.5% of the total ward population), 717 to the low strata (28.6% of the population), 525 to the moderate strata (16.2% of the population), and 1470 to the high strata (39.8% of the population). The resulting micro-stratification revealed malaria risk heterogeneity within 80 councils and identified wards that would benefit from community-level focal interventions, such as community-case management, indoor residual spraying and larviciding. Conclusion The micro-stratification approach employed is simple and pragmatic, with potential to be easily adopted by the malaria programme in Tanzania. It makes use of available routine data that are rich in spatial resolution and that can be readily accessed allowing for a stratification of malaria risk below the council level. Such a framework is optimal for supporting evidence-based, decentralized malaria control planning, thereby improving the effectiveness and allocation efficiency of malaria control interventions

Latent classes of emotional and behavioural problems in epidemiological and referred samples and their relations to DSM-IV diagnoses

Researchers\u2019 interest have recently moved toward the identification of recurrent psychopathological profiles characterized by concurrent elevations on different behavioural and emotional traits. This new strategy turned to be useful in terms of diagnosis and outcome prediction. We used a person-centred statistical approach to examine whether different groups could be identified in a referred sample and in a general-population sample of children and adolescents, and we investigated their relation to DSM-IV diagnoses. A latent class analysis (LCA) was performed on the Child Behaviour Checklist (CBCL) syndrome scales of the referred sample (N = 1225), of the general-population sample (N = 3418), and of the total sample. Models estimating 1-class through 5-class solutions were compared and agreement in the classification of subjects was evaluated. Chi square analyses, a logistic regression, and a multinomial logistic regression analysis were used to investigate the relations between classes and diagnoses. In the two samples and in the total sample, the best-fitting models were 4-class solutions. The identified classes were Internalizing Problems (15.68%), Severe Dysregulated (7.82%), Attention/Hyperactivity (10.19%), and Low Problems (66.32%). Subsequent analyses indicated a significant relationship between diagnoses and classes as well as a main association between the severe dysregulated class and comorbidity. Our data suggested the presence of four different psychopathological profiles related to different outcomes in terms of psychopathological diagnoses. In particular, our results underline the presence of a profile characterized by severe emotional and behavioural dysregulation that is mostly associated with the presence of multiple diagnosis