21 research outputs found
Synthesis, Biological Evaluation, and Three-Dimensional in Silico Pharmacophore Model for 蟽 1
Full text linkDetection of residual rifampicin in urine via fluorescence quenching of gold nanoclusters on paper
Full text linkThe synthesis of cyclic and acyclic long鈥恈hain arylpiperazine derivatives of salicylamide as serotonin receptor ligands
No full text4,6-Di(heteroaryl)-2-(N-methylpiperazino)pyrimidines as New, Potent 5-HT2A Receptor Ligands: A Verification of the Topographic Model
No full textA series of new 4,6-di(heteroaryl)pyrimidines containing an N-methylpiperazino group (6-13) or an ethylenediamine chain (15-20) in position 2 were synthesized and their 5-HT1A and 5-HT2A receptor affinities were determined. It was shown that the substituent effects on the 5-HT2A affinity are additive and could be described quantitatively. In a behavioral model it was also demonstrated that 6-11 are 5-HT2A receptor antagonists. The molecular modelling results suggested that the distances between the basic nitrogen atom and the two aromatic centers (d1 = 5.2-8.4 脜, d2 = 5.7-8.5 脜, and d3 = 4.6-7.3 脜) define the molecular topography of the 5-HT2A receptor antagonists under study
Novel 5-HT7 Receptor Inverse Agonists. Synthesis and Molecular Modeling of Arylpiperazine- and 1, 2, 3, 4-Tetrahydroisoquinoline-Based Arylsulfonamides
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Synthesis and Structure鈭扐ctivity Relationships of a New Model of Arylpiperazines. 3. 2-[蠅-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2- c
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