Dynamic recrystallization of Ti-based materials at crack surfaces at elevated temperatures –hybrid cellular automata simulation

In the study a Hybrid discrete-continuum Cellular Automata approach (HCA) based on coupling classical thermomechanics and logics of CA-switching to simulate new phase generation and grain growth is proposed. On the basis of the HCA the numerical experiments on thermal-activated recrystallization of pure titanium in the vicinity of crack edges were conducted. In doing so the 3D cellular automaton simulates the behavior of the V-notched specimen region that imitates the crack tip vicinity. Numerical experiments are aimed at calculating heat expansion in the material under study through taking into account thermal stresses accumulation and microrotation initiation. The latter gives rise to generation of new defects and increasing the local entropy

Dynamic recrystallization of Ti-based materials at crack surfaces at elevated temperatures –hybrid cellular automata simulation

In the study a Hybrid discrete-continuum Cellular Automata approach (HCA) based on coupling classical thermomechanics and logics of CA-switching to simulate new phase generation and grain growth is proposed. On the basis of the HCA the numerical experiments on thermal-activated recrystallization of pure titanium in the vicinity of crack edges were conducted. In doing so the 3D cellular automaton simulates the behavior of the V-notched specimen region that imitates the crack tip vicinity. Numerical experiments are aimed at calculating heat expansion in the material under study through taking into account thermal stresses accumulation and microrotation initiation. The latter gives rise to generation of new defects and increasing the local entropy

Genomic Classification of Cutaneous Melanoma

We describe the landscape of genomic alterations in cutaneous melanomas through DNA, RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 patients. We establish a framework for genomic classification into one of four sub-types based on the pattern of the most prevalent significantly mutated genes: mutant BRAF, mutant RAS, mutant NF1, and Triple-WT (wild-type). Integrative analysis reveals enrichment of KIT mutations and focal amplifications and complex structural rearrangements as a feature of the Triple-WT subtype. We found no significant outcome correlation with genomic classification, but samples assigned a transcriptomic subclass enriched for immune gene expression associated with lymphocyte infiltrate on pathology review and high LCK protein expression, a T cell marker, were associated with improved patient survival. This clinicopathological and multidimensional analysis suggests that the prognosis of melanoma patients with regional metastases is influenced by tumor stroma immunobiology, offering insights to further personalize therapeutic decision-makingclose3