PENGARUH PEMBELAJARAN KEWIRAUSAHAAN DAN EKSTRAKURIKULER WAJIB KEPRAMUKAAN TERHADAP KARAKTER KEWIRAUSAHAAN (Studi Kasus Peserta Didik Kelas XI SMA YPI Bandung)

Penelitian ini bertujuan untuk memperoleh data mengenai 1. Pembinaan karakter kewirausahaan pada pembelajaran kewirausahaan pokok pembahasan produksi ikan konsumsi peserta didik kelas XI SMA YPI Bandung, 2. Pembinaan karakter kewirausahaan di Gugus depan 03021-03022 pangkalan SMA YPI Bandung, 3. Karakter kewirausahaan peserta didik kelas XI SMA YPI Bandung, 4. Pengaruh pembinaan karakter kewirausahaan melalui pembelajaran kewirausahaan pokok bahasan produksi ikan konsumsi peserta didik kelas XI SMA YPI Bandung, 5. Pengaruh pembinaan karakter kewirausahaan dalam ekstrakurikuler wajib kepramukaan di Gugus depan 03021-03022 pangkalan SMA YPI Bandung. Metode penelitian yang dipergunakan metode survei tingkat eksplanasi asosiatif kausal. Teknik pengumpulan data dengan cara studi pustaka, kuesioner, dan observasi. Populasi pada penelitian ini, yaitu peserta didik kelas XI SMA YPI Bandung semester I yang berjumlah 22 orang. Hipotesis pada penelitian ini, yaitu 1. Terdapat pengaruh pembelajaran kewirausahaan terhadap karakter kewirausahaan peserta didik kelas XI SMA YPI Bandung, 2 Terdapat pengaruh ekstrakurikuler kepramukaan terhadap karakter kewirausahaan peserta didik kelas XI SMA YPI Bandung. Teknik pengolahan data menggunakan uji validitas, uji reliabilitas, uji normalitas data, analisis regresi linier sederhana, dan koefisien determinasi dengan menggunakan program SPSS 20.0 for windows. Hasil pengolahan data menunjukkan bahwa, 1. Pembinaan karakter kewirausahaan pada pembelajaran kewirausahaan peserta didik kelas XI SMA YPI menunjukkan kategori Baik dengan rata-rata 3,85, 2. Pembinaan karakter kewirausahaan di Gugus depan 03021-03022 pangkalan SMA YPI Bandung menunjukkan kategori Baik dengan rata-rata 3,78, 3. Karakter kewirausahaan peserta didik kelas XI SMA YPI Bandung menujukkan kategori Sangat Baik dengan rata-rata 4,04, 4. T¬erdapat pengaruh pembelajaran kewirausahaan terhadap karakter kewirausahaan peserta didik senilai 4,7 % itu berarti Y sebagian kecil dipengaruhi oleh X1, arti Ha1 dapat diterima dan Ho1 ditolak, 5. Terdapat pengaruh ekstrakurikuler kepramukaan terhadap karakter kewirausahaan peserta didik senilai 27,6 % itu berarti Y hampir setengahnya dipengaruhi oleh X2, arti Ha2 dapat diterima dan Ho2 ditolak. Kesimpulan dari penelitian ini yaitu secara parsial terdapat pengaruh positif pembelajaran kewirausahaan dan ekstrakurikuler kepramukaan terhadap karakter kewirausahaan peserta didik kelas XI SMA YPI Bandung. Sebagai akhir penelitian penulis menyampaikan saran kepada sekolah, guru, dan pembina Pramuka agar pembelajaran dan pelatihan dioptimalkan sebagai salah satu strategi untuk meningkatkan karakter kewirausahaan peserta didik. Kata kunci: Pembelajaran Kewirausahaan, Ekstrakurikuler Kepramukaan, Karakter Kewirausahaan

Achieving treatment goals of reducing or maintaining body iron burden with deferasirox in patients with β-thalassaemia: results from the ESCALATOR study

This analysis evaluated the effects of deferasirox on liver iron concentration in moderate and heavily iron-overloaded patients with β-thalassaemia from the ESCALATOR trial (n = 231). Mean liver iron concentrations (LIC) decreased significantly from 21.1 ± 8.2 to 14.2 ± 12.1 mg Fe/g dry weight (dw) at 2 yr (P < 0.001) in patients with LIC ≥7 mg Fe/g dw at baseline; patients with LIC <7 mg Fe/g dw maintained these levels over the treatment period. The proportion of patients with LIC <7 mg Fe/g dw increased from 9.4% at core baseline to 39.3% by the end of year 2. The results showed that deferasirox enabled therapeutic goals to be achieved, by maintaining LIC in patients with LIC <7 mg Fe/g dw at a mean dose of 22.4 ± 5.2 mg/kg/d and significantly reducing LIC in patients with LIC ≥7 mg Fe/g dw at a mean dose of 25.7 ± 4.2 mg/kg/d, along with a manageable safety profile

International sentinel site surveillance of patients with transfusional hemosiderosis treated with deferasirox in actual practice setting

Funding: This study was funded by Novartis Pharma AGObjective:The study evaluates the long-term deferasirox treatment of adult and pediatricpatients with chronic transfusional iron overload in clinical practice.Methods:In this non-interventional study, patients were observed for up to 3 years frominitiation of deferasirox treatment both prospectively and retrospectively for up to 1 yearprior to enrollment. The primary end points were the proportion of patients with≥1 notableincrease in serum creatinine (SCr), and≥1 notable increase in alanine aminotransferase (ALT).Results:Overall, 120 patients were enrolled and 51 completed the study, with a limited 3-yeardropout rate of 12.5% due to adverse events (AEs). Increase in SCr > 33% above baseline and theage-adjusted ULN (upper limit of normal) was observed in 14 patients (95%CI, 7.1-19.2). The ALTlevels >5 × ULN was observed in 1 patient. Most frequent AEs reported during treatment withdeferasirox include gastrointestinal disturbances.Conclusions:The long-term treatment with deferasirox was manageable in most transfusion-dependent patients with no unexpected safetyfindings. Regular monitoring and an adjusteddeferasirox dosing strategy per local labels allowed continued iron chelation treatment andcontrol of transfusional iron in the majority of patients on study

Adolescents and young adults with newly diagnosed primary immune thrombocytopenia

Current immune thrombocytopenia (ITP) guidelines target children and adults, leading to oversimplification. Adolescents and young adults (AYAS) comprise a separate group with distinct health and psychosocial issues. This study aimed to describe the clinical presentation and therapeutic strategies of ITP among AYAS. We analyzed data from two large ITP registries (PARC-ITP; CARMEN-France) and included newly diagnosed ITP patients (aged 12–25 years) with an initial platelet counts of <100×109/L. Patients with secondary ITP or non-immune thrombocytopenia (n=57) and pregnant women (n=10) were excluded. Of the 656 cases of AYAS with primary ITP registered from 2004 up to 2021, 12-month follow-up data were available for 72%. The initial median platelet count was 12×109/L. In 109 patients (17%), the diagnosis was incidental, without documented bleeding. Apart from gynecological bleeding, the clinical and therapeutical characteristics of females and males were similar. Platelet-enhancing drugs were reported in 66%, 45%, and 30% of patients at diagnosis, 1–6 months, and 6–12 months after diagnosis, respectively. Corticosteroids were the preferred treatment at all time points. At 12 months, 50% of all patients developed chronic ITP. In the subgroup of patients with initial severe thrombocytopenia (<20×109/L), those receiving frontline treatment had a higher remission rate at 1 year than those who followed an initial watch-and-wait strategy (53% and 32%; P<0.05). Our analysis indicates that the remission rate at 1 year may be associated with the initial treatment strategy. This hypothesis must be confirmed in prospective studies

Worldwide survey of T2* cardiovascular magnetic resonance in Thalassaemia

Introduction Thalassaemia major (TM) affects hundreds of thousands of patients worldwide but only a minority have access to regular blood transfusion and chelation therapy. Cardiovascular magnetic resonance (CMR) T2* measurement provides an accurate, reproducible measurement of cardiac iron which is the cause of heart failure and early death in many transfused TM patients. This technique has been adopted as part of routine management in many countries where survival is now approaching normal but little is known about the severity and effects of myocardial iron loading in different geographical regions. Purpose The aim of this study was to describe the burden of disease of myocardial siderosis (measured by T2*) in different populations throughout the world and to assess the relationship between T2* and outcome such as heart failure and cardiac death. Methods 34 worldwide centres were involved in this survey of 3376 patients from Europe, the Middle East, North America, South America, North Africa, Australia and Asia. Anonymised data on myocardial T2* values were analysed in conjunction with clinical outcomes (heart failure and death). Results Overall, 57.5% of patients had no significant iron loading (T2* >20ms), 22.6% had moderate cardiac iron (10ms50%) in South-East Asia had cardiac iron (T2* >20ms) at baseline. At the time of the first scan, 100 patients (3.3%) had confirmed heart failure, the majority of whom (77.0%) had myocardial T2* <10ms with almost all (99%) having T2* <20ms. There were 113 patients who subsequently developed heart failure. 92.0% of these had T2* <10ms and 99.1% had a T2* <20ms. There were 39 deaths. Cardiac T2* values were <10ms in 79.5%, with 92.3% <20ms. Conclusions Even in this well-treated cohort with access to transfusion, chelation and CMR, there is a large proportion of TM patients with moderate to severe cardiac iron loading. Low T2* (<10ms) is associated with cardiac failure and death. There is a huge unmet worldwide need in terms of access to specialist medical care (including transfusion and chelation therapy) together with advanced monitoring techniques (such as CMR)

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10&nbsp;years; 78.2% included were male with a median age of 37&nbsp;years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020

Three Decades of Experience in Managing Immune Thrombocytopenia in Children in Arab Countries

There are scattered and limited data in the literature on immune thrombocytopenia (ITP) in children from the Arab region. The aim of the current review is to present data from this region on the diagnosis, therapy, and morbidity associated with ITP. The first report was published three decades ago. It was assumed that there was a different disease pattern of ITP, but this was later discovered to be inaccurate and the frequencies of different ITP patterns were not different from other regions. The initial work-up for diagnosis of newly diagnosed ITP included routine bone marrow evaluation for all patients in most studies; however, a limited need for bone marrow for the initial evaluation was reported. An Egyptian multicenter study on the morbidity and mortality of intracranial hemorrhage (ICH) with other sporadic data was reported. Neither regional nor national guidelines for ITP management in most Arab countries have been reported. However, the use of initial intravenous immunoglobulin (IVIG) therapy in the Arabian Gulf region in contrast to corticosteroids in most other countries was obvious. Limited data on the use of anti-CD20, avoidance of unnecessary splenectomy, and the use of thrombopoietin receptor analogue in chronic ITP were published recently. A unified consensus for ITP management in the Arab region is essential but not yet realistic. More publications from this region are needed