2 research outputs found
Tandem Ullmann-Goldberg Cross-Coupling/Cyclopalladation-Reductive Elimination Reactions and Related Sequences Leading to Polyfunctionalized Benzofurans, Indoles, and Phthalanes
On exposure to a combination of Cu[I]- and Pd[0]-based catalysts, compounds such as 1 and 7 engage in tandem Ullmann-Goldberg cross-coupling and cyclopalladation-reductive elimination reactions to give benzofurans such as 8. Related reactions involving hetero-Michael additions of o-halogenated phenols or anilines to propiolates and the Pd[0]-catalyzed cyclization of the resulting conjugates provide, in a one-pot process, alternately functionalized benzofurans, indoles, or phthalanes.We thank the Australian Research Council and the Institute of
Advanced Studies for financial support including the provision
of scholarships to F.K. and M.A. as well as a postdoctoral
fellowship to Y.V. F.M. thanks the Higher Education Council
of the Government of Pakistan for support, and M.S.
acknowledges the support of the Islamic Government of Ira