Formulation and Evaluation of Herbal Emulgel of Pothos scandens Linn for Burn Wound Healing Activity

The main aim of this work was to formulate the leaf extract of Pothos scandens in to an emulgel and investigate their burn wound healing activity. Ethanolic extract of dried leaves of Pothos scandens were subjected to preliminary phytochemical evaluation and wound healing activities studies. Emulgel formulations were prepared using three types of gelling agents: Carbopol 934, Carbopol 940 and HPMC K4M. The influence of the type of the gelling agent on the drug release from the prepared emulgel was investigated. The prepared emulgel were evaluated for their physical appearance, pH, viscosity, spreadability, in vitro drug release, pharmacological activity and stability. It was finally concluded that the formulation F1 with 1%w/w Carbopol 940 was found to be more promising formulations as it shows better physicochemical characteristics and higher pharmacological activity compared to other formulations. Herbal emulgel of ethanolic extract of Pothos scandens shows significant improvement in burn wound contraction and hence this is a promising candidate in burn wound healin