Betatrophin is correlated with glucagon and insulin release rather than insulin resistance marker in type 2 diabetes mellitus Iraqi women

Background: Betatrophin mainly expressed in liver and adipose tissue, stimulates pancreatic β-cell proliferation in insulin resistance state and improves metabolic process‎ regulation. This study aimed to understand effective roles of betatrophin in diabetic and non-diabetic Iraqi women. Also, it’s correlation with some insulin markers, metabolic parameters and glucagon.Methods: Eighty women participated in this cross-sectional study, (mean body mass index: 21 - 49 kg/m2; mean age: 25-50 years) were enrolled and classified according to the presence of diabetes into 2 groups (40 diabetic and 40 non-diabetic). Anthropometric, biochemical and metabolic parameters measured.Results: Betatrophin level had no statistically significant differences between non-diabetics and diabetics. Serum betatrophin levels had no statistically significant positive or negative correlations with age, anthropometric, lipid profile, diabetic parameters, thyroid stimulating hormone, glucagon, irisin, glucagon like peptide -1 and hepatocyte growth factor except uric acid (r=0.2539, P =0.0231). Serum betatrophin had no statistically significant correlations with all variables in non-diabetic and diabetic groups except with homoeostasis model assessment- for β-cell function (HOMA-β) and glucagon (r=0.3647, P=0.0207; r=0.3403, P=0.0317 respectively) in the diabetic group. Stepwise regression showed that only uric acid was independently related factors to circulating betatrophin β=‎0.8500, P=‎0.02.Conclusions: Betatrophin was positively correlated with HOMA-β and glucagon in type 2 diabetes mellitus women. Uric acid was a direct independent predictor of betatrophin level

Study the Correlation of the Leptin to Adiponectin Ratio with Estimation of Insulin Resistance in Obese and Non Obese Individuals

Background: Leptin to Adiponctin ratio (LAR) has been reported as potentially useful measure of insulin resistance (IR). Obesity is the dominant cause of insulin resistance. The concentration of leptin rises with obesity, whereas that of adiponectin decreases with obesity. We investigated whether LAR may serve as a better predictor than either leptin or adiponectin alone for (IR) and study the correlation between LAR and insulin in obese individuals.Subjects and methods: this study included 90 non-diabetic Iraqi males (45 obese with mean age (39.80±8.10) years old, range from (30-55) year and 45 non-obese individuals with mean age (42.0±7.04) years old, range from (31-54) year. Leptin, adiponectin and insulin were measured using enzyme linked immunosorbent assay technique (ELISA).Results: LAR, IR and leptin show significant highly increased in obese group compared to non-obese healthy subjects, while Adiponectin level show significant high decreased in obese group. The pearson correlation analysis found LAR had strong significant positive correlation with leptin (r= 0.400, p<0.007) and strong significant negative correlation with adiponectin (r= -0.78, p<0.00).   Conclusion: the leptin-to-adiponectin ratio (LAR) correlates with insulin resistance better than either leptin or adiponectin levels alone. Keywords: Lar, Ir, Leptin, Adiponectin and Obeaity