On the existence of solutions for strongly nonlinear differential equations

AbstractThe objectives of this paper are twofold. Firstly, to prove the existence of an approximate solution in the mean for some nonlinear differential equations, we also investigate the behavior of the class of solutions which may be associated with the differential equation. Secondly, we aim to implement the homotopy perturbation method (HPM) to find analytic solutions for strongly nonlinear differential equations

Structural analysis of urate oxidase in complex with its natural substrate inhibited by cyanide: Mechanistic implications

<p>Abstract</p> <p>Background</p> <p>Urate oxidase (EC 1.7.3.3 or UOX) catalyzes the conversion of uric acid and gaseous molecular oxygen to 5-hydroxyisourate and hydrogen peroxide, in the absence of cofactor or particular metal cation. The functional enzyme is a homo-tetramer with four active sites located at dimeric interfaces.</p> <p>Results</p> <p>The catalytic mechanism was investigated through a ternary complex formed between the enzyme, uric acid, and cyanide that stabilizes an intermediate state of the reaction. When uric acid is replaced by a competitive inhibitor, no complex with cyanide is formed.</p> <p>Conclusion</p> <p>The X-ray structure of this compulsory ternary complex led to a number of mechanistic evidences that support a sequential mechanism in which the two reagents, dioxygen and a water molecule, process through a common site located 3.3 Å above the mean plane of the ligand. This site is built by the side chains of Asn 254, and Thr 57, two conserved residues belonging to two different subunits of the homo-tetramer. The absence of a ternary complex between the enzyme, a competitive inhibitor, and cyanide suggests that cyanide inhibits the hydroxylation step of the reaction, after the initial formation of a hydroperoxyde type intermediate.</p

Starost i rast glavoča travaša Zosterisessor ophiocephalus Pallas, 1811 u zaljevu Gabes (Tunis, središnji Mediteran)

Zosterisessor ophiocephalus is currently an important component of the eastern Mediterranean inshore fisheries. In Tunisia it was recorded for the first time in the Gulf of Gabes in 1993, where it is now an important fished species. In this study age and growth parameters were determined in the Gulf of Gabes (southeast of Tunisia) based on otolith analysis of 824 specimens caught between September 2006 and August 2007. Monthly changes in marginal increments, determined from alternation of macroscopic opaque and translucent bands, of Zosterisessor ophiocephalus sagittae were examined. These results allowed us the estimation of the approximate age to the appearance of each annulus. The observed age was 6 years old for both sexes. Von Bertalanffy parameters based on length at age data were TL∞ = 24.83 ± 1.69 cm, K = 0.19 ± 0.03 year-1 and t0 = - 0.91 ± 0.12 for males and TL∞ = 24.13 ± 1.17 cm, K = 0.20 ± 0.02 year-1 and t0 = - 0.80 ± 0.09 for females. The length-weight relationship for both sexes of Zosterisessor ophiocephalus is Wt = 0.021 TL 2.789. The size at which 50% of females and males matured was respectively 12.65 cm and 13.91 cm total length (TL). The age at which 50% of females and males matured was respectively 2.9 and 3.5 years.Zosterisessor ophiocephalus je trenutno važna komponenta priobalnog ribolova istočnog Mediterana. U Tunisu je prvi put zabilježen u zaljevu Gabes 1993. godine, gdje je sada važna ribolovna vrsta. U ovoj studiji određivani su parametri starosti i rasta u zaljevu Gabes (jugoistočno od Tunisa) na temelju analize otolita 824 primjerka, ulovljenih između rujna 2006. i kolovoza 2007. godine. Starost je utvrđena na temelju fosilnih naraštajnih prstenova na otolitima (sagitta) vrste Zosterisessor ophiocephalus. Ovi rezultati su nam omogućili procjenu približne starosti pojavom svakog prstena kruga /annulus. Utvrđene su najstarije jednike koje su imale 6 godina za oba spola. Von Bertalenffyjevi parametri zasnovani na podatcima o duljini pri određenoj starosti bili su; TL∞ = 24.83 ± 1.69 cm, K = 0.19 ± 0.03 godina-1 i t0 = - 0.91 ± 0.12 za mužjake i TL∞ = 24.13 ± 1.17 cm, K = 0.20 ± 0.02 godina-1 i t0 = - 0.80 ± 0.09 za ženke. Dužinsko-maseni odnos za oba spola vrste Zosterisessor ophiocephalus je Wt = 0,021 TL 2.789. Veličina kod koje 50% ženki i mužjaka sazrijeva bila je 12,65 cm i 13,91 cm ukupne duljine (TL). Dob kod koje 50% ženki i mužjaka sazrijeva je između 2,9 i 3,5 godina starosti

Toward a Deep Learning Approach for Automatic Semantic Segmentation of 3D Lidar Point Clouds in Urban Areas

peer reviewedSemantic segmentation of Lidar data using Deep Learning (DL) is a fundamental step for a deep and rigorous understanding of large-scale urban areas. Indeed, the increasing development of Lidar technology in terms of accuracy and spatial resolution offers a best opportunity for delivering a reliable semantic segmentation in large-scale urban environments. Significant progress has been reported in this direction. However, the literature lacks a deep comparison of the existing methods and algorithms in terms of strengths and weakness. The aim of the present paper is therefore to propose an objective review about these methods by highlighting their strengths and limitations. We then propose a new approach based on the combination of Lidar data and other sources in conjunction with a Deep Learning technique whose objective is to automatically extract semantic information from airborne Lidar point clouds by enhancing both accuracy and semantic precision compared to the existing methods. We finally present the first results of our approach

New Blended Learning Strategy Based on Flipped-Learning for Vocational Work-Linked Training

In a changing Moroccan educational landscape, Addressing teaching development needs is becoming a major issue in vocational work-linked Training. In this context, this paper present a new blended learning strategy based on the flipped classroom, using a social learning platform as support. Through this strategy, we increased the time dedicated to regulation by the implementation of a self-regulation and a co-regulation online in first time, and other regulation in classroom. The result showed that this strategy guides and increases the time of initial training, and improve the efficiency, performance of student teachers while supporting teaching needs and self-learning skills. Keywords: Blended learning, flipped learning, vocational work-linked Trainin