HER2 Over Expression in Malignant Palpable Breast Lumps of Pre and Postmenopausal Women Attending RICK.

Back ground: Human Epidermal growth factor Receptor 2 (HER-2/neu) over expression in breast cancer is associated with poor outcome and decrease disease free survival (DFS). The aim of this study was to evaluate the over expression of HER2/neu among premenopausal and postmenopausalfemales presented with malignant palpable breast lumps to Radio Isotope Center Khartoum (RICK).Methods: The study was a case-control conducted among patients attending Radiation Isotopes Centre Khartoum (RICK). A total of 328 women were randomly selected. Data were collected by a pre coded, pre tested questionnaire. Tissue biopsies of breast lumps had been analyzed using immunohistochemical techniques for HERR-2/neu over expression and its relation to other prognostic factors was evaluated.Results: HER-2/neu + vein first pregnancy at . 23 years, were 32 (41%) in the cases, 6 (35%) in the controls of premenopausal women, and 21(44%) in the cases, 5 (38%) in the controls of postmenopausal women. HER-2/neu + veexpression in relation to age at menarche . 12 years was39 (51%) in the cases, 7(39%) in the controls of premenopausal women, and 36 (56%) in the cases, 7 (45%) in the controls of postmenopausal women. HER-2/neu+ vein relation to Body Mass Index > 29 kg/m2 showed 7 (37%) in the cases, 2 (33%) in the controls of premenopausal women(x2=0.024), and 8(38%) in the cases, 2(40%) in the controls of postmenopausal women (x2=0.006). HER-2/neu+ veexpression in relation to history of abortion or miscarriage (ever) was found to be 21 (39%) in the cases, 4 (33%) in the controls of premenopausal women, and 18 (44%) in the cases, 3 (33%) in the controls among postmenopausal women. HER-2/neu+ veexpression in relation to the history of breast cancer in a first degree relatives was 3 (25%) in the cases, 1(50%) in thecontrols of premenopausal women, and 4 (22%) in the cases, 2 (28%) in the controls of postmenopausal women. HER-2/neu+ veexpression in relation to the use of oral contraceptives was 3 (37%) in the cases, 1(50%) in the controls among premenopausal women, and 3 (27%) in thecases, 1 (50%) in the controls of postmenopausal women.Conclusion: The study confirmed an etiological association between HER2/neu+ve and HER2/neu . ve and age at first pregnancy . 23 years, age of menarche at . 12 years, abortion or miscarriage in premenopausal and postmenopausal Sudanese women, while an etiological association was confirmed between HER2/neu+ve and HER2/neu .ve, and BMI in premenopausal women, and the family history of cancer in pos menopausal women.Keywords: Human Epidermal, Growth factor, Recepto

Educational Innovation in the Sultanate of Oman and its Research Requirements: a research Map for the Department of Educational Foundations and Administration

This study intended to provide a research map that shows the most important research issues and educational challenges facing education in the Sultanate of Oman in the light of contemporary educational innovations. A descriptive research method was used. The procedures followed in the study included a review of educational research maps in the colleges of education, conducted a theoretical analysis of the relationship between global changes and their impact on the areas of educational innovation, identify areas of educational innovation in Oman, and Meta analysis of research conducted at the Department of Educational Foundations and Administration. Based on the analysis and interpretation of data collected from 120 research participants, consisting of 10 faculty members, 15 Master students, 20 experts from the Ministry of Education and Ministry of Higher Education, and 75 school principals representing different provinces, a research map, with its objectives, scopes, and mechanics of implementation, was developed

The influence of different joining processes on mechanical performance of carbon fiber/polyamide (CF/PA6) composites

تستخدم المواد المركبة المصنوعة من مادة البولي أميد (PA6) المقوى بألياف الكربون (CF) على نطاق واسع كمواد هيكلية في صناعات السيارات والفضاء نظرًا لخصائصها المتميزة. ومع ذلك ، نظرًا لمتطلبات السلامة الهيكلية للمواد المركبة ، لا تزال هناك محدودية فيما يتعلق بالإنتاج الفعلي للمواد المركبة المكونة من (CF/ PA6). الروابط القوية لصفائح CF/PA6 مطلوبة بشدة  لعمل تصميم خفيف الوزن يستخدم في العديد من المجالات. بهدف إجراء مقارنات ، تم تدراسة مختلف طرق المعالجة مثل الربط بمواد لاصقة والربط الحراري لتشكيل روابط اللإلفة بين صفحتين مركبتين من (CF/PA6). كما تم دراسة تأثير الطرق المختلفة ومتغيرات المعالجة  المختلفة على مقاومة القص للروابط. أظهرت النتائج أنه من السهل جدًا التعامل مع الروابط اللاصقة التقليدية وقد تتشكل روابط  أقوى إلى حد ما. يمكن استخدام الروابط الحرارية القائمة على التوصيل الكهربائي عن طريق CF لتشكيل توصيلات متلدنة بالحرارة مع المرونة في التصميم. يمكن أن تزيد الروابط الحرارية عن طريق الضغط الساخن من قوة الاتصال؛ عندما تتشكل بالضغط الساخن في ظروف مثالية في درحة حرارة تبلغ 250 درجة مئوية وضغط 2.5 ميجا باسكال ، فإن قوة القص للمفصل 138.85 ميجا باسكال. وبالتالي تم التأكيد على أنه يمكن الحصول على روابط قوية لأجزاء الصفائح للمادة المركبة CF/PA6  عن طريق الالتصاق الحراري عبرعملية الضغط  الساخن.Carbon fiber (CF) reinforced polyamide (PA6) composite materials are broadly used as structural materials in the automotive and aerospace industries due to their distinguished properties. However, due to requirements for the structural integrity of composite materials, there are still limitations in connection of the actual production of CF/PA6 composite. Strong joints of CF/PA6 laminates are highly required for the lightweight design in many fields. Aiming at making comparisons, different processing methods such as adhesive bonding and thermal jointing to form single lap joints between the two CF/PA6 composite laminates are studied. The influences of different processing methods and parameters on the shear strength of joints were also studied. Results showed that conventional adhesive bonding is quite easy to handle and may form rather stronger connections. Thermal joining based on electrical conductors of CF can be used to form a thermoplastic flexible joint design. Thermal joints by hot pressing can further increase the connection strength; when formed by hot pressing under optimum conditions of 250 °C and 2.5MPa, the joint has a shearing strength of 138.85 MPa. It is consequently confirmed that a strong joint of CF/PA6 composite parts could be obtained by thermal joints via the hot pressing process

Studying of heart diseases prevalence, distribution and cofactors in Sudanese population

Background: the following study aimed to reveals the heart diseases (HD) prevalence, distribution and co-factors in Sudanese population during June 2014-June 2015 and to answer the questions related to, in Sudan.Methods: The data collected from different hospitals as gender, age, body mass index BMI, smoking habits, residential states, Pathologies, cardiothoracic ratio CCT, symptoms and breathing rate.Results: showed that HD were predominant among male with 56% and peaked among 65-77 year old, most of sample were either obese or overweight   representing 57% or 35% respectively. The common cofactors for HD were the socio-economic, smoking, hypertension and obesity which representing 90%, 75%, 60% and 57% respectively. The heart diseases HD incidence in Khartoum, Aljazeera, White Nile, Red Sea, and West of Sudan was 40%, 25%, 20%, 10% and 5% respectively. The common type of HD was Coronary Arteries, Valves, Myocardial infarction, and Congestive Heart Failure representing 45%, 17%, 23%, and 15% respectively. And signs were Hypertension, Diabetes mellitus, High Cholesterol, breathing rate, edema, palpitation with relative frequencies 9%, 11%, 6%, 12%, 8% and 10% respectively. Patients’ cardiothoracic ratio CTR exceeding normal level (0.5), A significant relationship between CTR and Breathing rate (BR) (R2 = 0.8) fits in CTR=0.02BR+0.2 as well between age and BR (R2) fits in BR=0.21age + 12.84. And all patients had BR exceeding the adult normal range (12-20).Conclusions: HD could be as endemic to increase mortality following the uneasy avoidable cofactors in the nearest future.

Unmasking of Brugada syndrome by lamotrigine in a patient with pre-existing epilepsy: A case report with review of the literature

Brugada syndrome is an inherited cardiac channelopathy arising from mutations in voltage-gated cardiac sodium channels. Idiopathic epilepsy portrays a coalescent underlying pathophysiological mechanism pertaining to the premature excitation of neuronal voltage-gated ion channels resulting in the disruption of presynaptic neurons and the unregulated release of excitatory neurotransmitters. The coexistence of epilepsy and Brugada syndrome may be explained by mutations in voltage-gated ion channels, which are coexpressed in cardiac and neural tissue. Moreover, the incidence of sudden unexpected death in epilepsy has been associated with malignant cardiac arrhythmias in the presence of mutations in voltage-gated ion channels. Lamotrigine is an antiepileptic drug that inhibits neuronal voltage-gated sodium channels, thus stabilizing neural impulse propagation and controlling seizure activity in the brain. However, lamotrigine has been shown to inhibit cardiac voltage-gated sodium channels resulting in a potential arrhythmogenic effect and the ability to unmask Brugada syndrome in genetically susceptible individuals. We are reporting a case of a 27-year-old male patient with a background of presumed idiopathic epilepsy who was initiated on lamotrigine therapy resulting in the unmasking of Brugada syndrome and the onset of syncopal episodes. This case provides further evidence for the arrhythmogenic capacity of lamotrigine and highlights the relationship between epilepsy and Brugada syndrome. In this report, we aim to review the current literature regarding the associations between epilepsy and Brugada syndrome and the impact of lamotrigine therapy on such patients

The Association of Lymphocyte count, CRP, D-Dimer, and LDH with Severe Coronavirus Disease 2019 (COVID-19): A Meta-Analysis

Background: The rapid progression of Coronavirus disease 2019 (COVID-19) and its increasing burden on health systems necessitate the identification of parameters of severe infection to help in monitoring, prognoses and development of treatment algorithms. Objectives: This review aims to investigate the association of lymphocyte count, CRP, LDH, and D-Dimer with the severity of COVID-19. Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The databases of MEDLINE/PubMed, WHO-Virtual Health Library (VHL), and ScienceDirect were used for the systematic search. Random effects model was used to estimate the pooled standardized mean differences (SMD) with the corresponding 95% confidence interval (CI), using OpenMeta Analyst software. Results: A total of 11 studies, with 2437 COVID-19 patients, which fulfilled the eligibility criteria were included in the meta-analysis. The analysis revealed that lymphocyte count was significantly lower in patients with the severe form of COVID-19 (SMD = - 1.025, P value <.001). Also, the analysis of SMD showed that patients with severe COVID-19 have a significantly higher serum levels of CRP (SMD = 3.363, P value <.001), D-Dimer (SMD = 1.073, P value <.001), and LDH (SMD = 3.345, P value <.001). Conclusion: Low lymphocyte count and high levels of CRP, LDH, and D-Dimer are associated with severe COVID-19. These laboratory markers could be used as clinical indicators of worsening illness and poor prognosis of COVID-19

Urinary biomarkers for lupus nephritis: a systems biology approach

Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disorder. Kidney involvement, termed lupus nephritis (LN), is seen in 40–60% of patients with systemic lupus erythematosus (SLE). After the diagnosis, serial measurement of proteinuria is the most common method of monitoring treatment response and progression. However, present treatments for LN—corticosteroids and immunosuppressants—target inflammation, not proteinuria. Furthermore, subclinical renal inflammation can persist despite improving proteinuria. Serial kidney biopsies—the gold standard for disease monitoring—are also not feasible due to their inherent risk of complications. Biomarkers that reflect the underlying renal inflammatory process and better predict LN progression and treatment response are urgently needed. Urinary biomarkers are particularly relevant as they can be measured non-invasively and may better reflect the compartmentalized renal response in LN, unlike serum studies that are non-specific to the kidney. The past decade has overseen a boom in applying cutting-edge technologies to dissect the pathogenesis of diseases at the molecular and cellular levels. Using these technologies in LN is beginning to reveal novel disease biomarkers and therapeutic targets for LN, potentially improving patient outcomes if successfully translated to clinical practice