Primary Cutaneous B-Cell Lymphomas

Primary cutaneous B-cell lymphomas (PCBCL) are a heterogeneous group of mature B-cells neoplasms that present in the skin without evidence of nodal or systemic involvement. The clinical and pathologic features of PCBCL differ significantly from the equivalent nodal lymphomas. Three main subtypes of PCBCL are recognized by the 2016 revised WHO classification. Studies have shown that PCBCLs are characterized by distinct immunophenotypic features, chromosomal aberrations and gene rearrangements which provide further support for their classification as separate entities from their nodal types

MYC (MYC proto-oncogene, bHLH transcription factor)

Review the structure, function, and role of CMYC gene in tumorigenesi

Acute Lymphoblastic Leukemia with Hypereosinophilia

Acute lymphoblastic leukemia (ALL) with hypereosinophilia is a rare disease, with the majority of reported cases being B-lineage ALL. Although eosinophilia is considered a reactive, non-neoplastic epiphenomenon, it adversely affects patient outcomes, both in children and adults. It is a distinct clinical entity by World Health Organization (WHO) 2008 and commonly associated with a unique cytogenetic abnormality

t(4;11)(q23;p15) NUP98/RAP1GDS1

Review on t(4;11)(q23;p15) with data on clinics

Chronic Eosinophilic Leukemia-Not Otherwise Specified (CEL-NOS) - Idiopathic Hypereosinophilic Syndrome (IHES)

Chronic eosinophilic leukemia (CEL) not otherwise specified (NOS) and idiopathic hypereosinophilic syndrome (HES) are rare hematologic disorders characterized by chronic, unexplained eosinophilia with manifestation of organ involvement related to eosinophil infiltration, in the absence of evidence of secondary causes such as parasitic infestation, allergy, or neoplasm. Neither CEL-NOS nor idiopathic HES show Ph chromosome/ BCR-ABL fusion gene or other genetically defined entities such as PDGFRA, PDGFRB, or FGFR1 abnormalities

Double Hit Lymphoma (DHL)::Triple Hit Lymphoma (THL)

The role of cytogenetics in identification of double-hit lymphoma, a subset of a high grade large B-cell lymphoma

i(7)(q10)

Isochromosome 7q, i(7)(q10), is a rare recurrent aberration found in various hematological neoplasms. In Mitelman's data base, i(7q) is the sixth mostcommon isochromosome after i(17q), i(8q), i(1q), i(12p), and i(6p) in human neoplasms. The incidence of this abnormality, and genes involved are presented in this review

BCL2 (B-Cell Leukemia/Lymphoma 2)

BCL2 is the milestone of apoptosis-regulatory genes. It contributes to tumorigenesis by blocking programmed cell death as such, promoting cell survival. The aberrant expression of BCL2 gene is strongly associated with resistance to chemotherapy and radiation. This review outlines the structure, function, and role of BCL2 gene in cancer

del(6q)

Review on deletion of 6q in hematological malignancies, genes involvedand clinical significance

dup(1q) in ALL

Review on duplication of 1q in acute lymphoblastic leukemia, with data on clinics, and the genes involved