Modeling the determinants of gestational diabetes in Shiraz

Background: Diabetes mellitus (DM) is a metabolic disorder and the 5th cause of death in developed countries. Gestational diabetes mellitus (GDM) is an impaired glucose tolerance in pregnancy period. Fourteen-eighteen percent of pregnant women are at risk of GDM, 3-4 percent of whom suffer from it. The present study was conducted to determine the most important causes of DM in a regression model. Materials and Methods : In a case control study 70 GDM patients were compared with 350 non-GDM pregnant women referring to Shiraz hospital for delivery. The data were gathered and analyzed using Fisher exact test, in univariate t-test method and binary logistic regression at multivariate model. Results : The mean age in cases and controls was 31.2 ± 6.03 and 26.32 ± 5.03, respectively. All of variables showed significant difference between two groups, except history of infertility malformation of twine pregnancy, toxemia and previous preterm delivery having no relation with GDM. In final regression model, GD history (OR=21.93), glocosuria in three trimester (OR=10.34), age older 35 years (OR=9.57), family history of GD (OR=8.13) and preeclampsia (OR=3.81) were the most important predictors of GDM, respectively. Conclusion : To prevent diabetes and its unpleasant outcomes in pregnant women it is suggested that they should avoid creating factors of glocosuria, especially in older mothers with family history of GD and GDM history

Gestational diabetes related unpleasant outcomes of pregnancy

Background: Diabetes accompanies over 8 of all pregnancies. It is associated with increased risk of complications of pregnancy and prenatal mortality. This study was conducted to determine the disadvantages of gestational diabetes on mother and new born in order to prevent neonatal and marital unpleasant outcomes. Material and Methods: The present historical cohort study includes 420 mothers referring to Shiraz hospitals in 2006. Seventy cases were suffering from gestational diabetes. Data were pooled by questionnaires and analyzed by t-test and fisher exact tests in SPSS. Results: The recurrence rate of gestational diabetes was 72.4. There was a significant difference between the two groups in dead fetus (RR= 8.87), macrosommia (RR= 7.38), respiratory distress (RR= 5.16), hypoglycemia (RR= 13.38), neonatal jaundice (RR= 3.28), need to respiratory rehabilitation (RR= 3.17), anomalies (RR= 7.28) and cesarean delivery (RR= 1.96) (p0.05). Conclusion: T his study showed that dead fetus, macrosomia, respiratory distress, hypoglycemia, and neonatal jaundice are more common in women with gestational diabetes than in other women. There fore, diabetes preventive practices are especially essential in pregnant women because of the unfavorable effects on labor and newborn baby