Screening of Indole-3-Acetic Acid (IAA) Productions by Endophytic Fusarium oxysporum Isolated from Phyllanthus niruri

Ten newly isolated endophytic fungi from Phyllathus niruri Linn. were identified as Fusarium oxysporum. These isolates were screened out for their productivity of indole acetic acid (IAA) by the salkowski's method. Out of these isolates, two isolates showed high amount of indole acetic acid production, which were FO9 and FO10 with concentration of 23.52 μg/ml and 5.95 μg/ml, respectively

Finite Element Model of Machining with High Pressure Coolant for Ti- 6Al-4V alloy

This study present a series of finite element models for high-pressure jet-assisted machining of Ti-6Al-4V alloy. The application of Fluid- Structure Interaction (FSI) together with the Johnson-Cook plasticity model, Cockcroft-Latham chip separation criteria and EOS polynomial were implemented to study the effect of coolant pressure on chip formation, cutting force and cutting temperature. The resulting motion of fluid at the tool-chip interface, chip breakage, cutting force as well as temperature generation at the tool-chip interfaceis then interpreted, analyzed and compared to their real experimental results. The models simulate interactions between the fluid and solid structure, where continuous chip formation was observed when simulation in conventional coolant supply while chip breakage was clearly evident as high-pressure coolant was introduced. Increasing coolant pressure significantly reduce the friction at the tool-chip interface, which significantly reduced the cutting force and cutting temperature

Effect of Moulding Temperature on Mechanical Properties of Pure Aluminum Sand Casting

In this study, mechanical properties (Tensile test, Brinell hardness and microstructure analysis) of pure aluminium after sand casting were investigated. Tensile test, Brinell hardness and microstructure analysis were performed using MAX text software, Universal Testing Machine and Escope with Clemax Imager, respectively. Sand cast aluminium was observed to have good tensile and hardness properties. From the observations, sand cast sample had uniform distribution of aluminium. &nbsp

Surface Integrity Study For FC300 Cast Iron Using TiAIN Ball End Mill

Finishing of FC300 gray cast iron predominantly done by manual polishing. Study the surface integrity of FC300 after machining is crucial to investigate the surface characteristics before polishing. This work aims to investigate the surface profiles and subsurface alterations induced by milling of FC300 gray cast iron using TiAlN Ball end mill. Machining trials were performed using CNC variaxis machine in dry condition at the cutting speeds of 66-99 m/min, feed rates of 0.27-0.42 mm/tooth and constant depth of cut of 0.1 mm. The results shows that the surface roughness decreased as the cutting speed increased from 66 m/min to 88 m/min. Smooth and shiny surface profiles appeared at the lower cutting speed of 66 m/min due to effect of lubrication layer that formed from the small fragmented graphite flakes. When the cutting speed increased to 99 m/min, surface profiles appeared with smeared and large graphite flakes probably due to higher rotational impact from the cutting tool. Analysis of subsurface microstructure observed bending effects at the region where worn cutting tool applied. Severe crack nucleation’s were evidence to reflect severe rubbing action from worn cutting tool

Insects

Cosmodela aurulenta (Coleoptera: Carabidae), or commonly known as the golden-spotted tiger beetle, is a species commonly found in open areas or in lowlands near riverbanks. The species is 14 to 16 mm in length, the body is dark greenish with three distinctive spots on each sides of the elytra. There is also the presence of pale coloured hairs on the abdomen and legs. The species are known to be opportunistic predators of smaller invertebrates, with characteristic large mandibles and enlarged compound eyes. The species is also observed to show brief flights

Congenital Diarrhea and Cholestatic Liver Disease: Phenotypic Spectrum Associated with MYO5B Mutations

Myosin Vb (MYO5B) is a motor protein that facilitates protein trafficking and recycling in polarized cells by RAB11- and RAB8-dependent mechanisms. Biallelic MYO5B mutations are identified in the majority of patients with microvillus inclusion disease (MVID). MVID is an intractable diarrhea of infantile onset with characteristic histopathologic findings that requires life-long parenteral nutrition or intestinal transplantation. A large number of such patients eventually develop cholestatic liver disease. Bi-allelic MYO5B mutations are also identified in a subset of patients with predominant early-onset cholestatic liver disease. We present here the compilation of 114 patients with disease-causing MYO5B genotypes, including 44 novel patients as well as 35 novel MYO5B mutations, and an analysis of MYO5B mutations with regard to functional consequences. Our data support the concept that (1) a complete lack of MYO5B protein or early MYO5B truncation causes predominant intestinal disease (MYO5B-MVID), (2) the expression of full-length mutant MYO5B proteins with residual function causes predominant cholestatic liver disease (MYO5B-PFIC), and (3) the expression of mutant MYO5B proteins without residual function causes both intestinal and hepatic disease (MYO5B-MIXED). Genotype-phenotype data are deposited in the existing open MYO5B database in order to improve disease diagnosis, prognosis, and genetic counseling.This research was funded by Jubiläumsfonds der Österreichischen Nationalbank, grant no.16678 (to A.R.J.), grant no. 18019 (to G.-F.V.) and Tiroler Wissenschaftsfonds, grant No. 0404/2386 (toG.-F.V.).info:eu-repo/semantics/publishedVersio

Reconstruction and identification of tau lepton decays to hadrons and tau neutrino at CMS

This paper describes the algorithms used by the CMS experiment to reconstruct and identify tau to hadrons + tau neutrino decays during Run 1 of the LHC. The performance of the algorithms is studied in proton-proton collisions recorded at a centre-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 19.7 inverse femtobarns. The algorithms achieve an identification efficiency of 50-60%, with misidentification rates for quark and gluon jets, electrons, and muons between per mille and per cent levels.Comment: Replaced with published version. Added journal referenc

Reconstruction and identification of τ lepton decays to hadrons and ντ at CMS

This paper describes the algorithms used by the CMS experiment to reconstruct and identify tau -> hadrons + nu(tau) decays during Run 1 of the LHC. The performance of the algorithms is studied in proton-proton collisions recorded at a centre-of-mass energy of 8 TeV, corresponding to an integrated luminosity of 19.7 fb(-1). The algorithms achieve an identification efficiency of 50-60%, with misidentification rates for quark and gluon jets, electrons, and muons between per mille and per cent levels

Extraction and encapsulation of phytocompounds from Withania coagulans for therapeutic uses

Withania coagulans Dunal is a plant that is native to the Asia-temperate and Asiatropical regions. It is used in the traditional system of medicine and reported to possess a multitude of medicinal benefits. Given the adverse side effects and disease resistance observed for current drugs, there is an increased thrust in the development of natural, plant-derived therapeutic molecules as an alternative. Withania coagulans is one such plant with proven therapeutic effects. This study aims to focus on the wound healing and anti-cancer properties of Withania coagulans, by extracting a concentrated form of the phytocompounds from the berries and encapsulating it in polymeric carriers to achieve a controlled and sustained release system. The phytocompounds were extracted using organic solvents and then encapsulated into PLGA of different molecular weights. The encapsulation and release of the phytocompounds from polymeric microparticles of varying molecular weights was analysed. The degradation of the PLGA microparticles over time was also studied. It is evident from the studies that the phytocompounds can be successfully encapsulated in PLGA microparticles and a controlled sustained release can be achieved. Some of the preliminary in vitro testing of the therapeutic effects of the phytocompounds also show a promising direction for the use of the extracts. Detailed studies would be carried out in the future to prove the wound healing and anti-cancer properties of the extract on cells and also the efficacy of the carrier system for such applications.Bachelor of Engineering (Materials Engineering