Asciminib-a magic bullet for chronic myeloid leukemia with T315I mutation: a case series

Chronic myeloid leukemia (CML) is a type of myeloproliferative neoplasm typically characterized by the presence of the Philadelphia chromosome. The advent of tyrosine kinase inhibitors (TKIs) has revolutionized the treatment of most CML patients. However, resistance to TKIs poses a significant challenge, leading to poor treatment outcomes and prognosis in some patients. Fortunately, the introduction of asciminib, a novel allosteric BCR-ABL1 inhibitor, has provided a ray of hope. We present three cases in this report that highlight the remarkable efficacy of asciminib seen in our patients. All of these patients initially responded positively to conventional TKIs but developed a T315I mutation in the BCR-ABL fusion protein during their chemotherapy, rendering conventional TKIs ineffective and resulting in loss of response. Asciminib led to the achievement of a major molecular response in all of our patients

Post-Operative Outcome in Patients Who Have Undergone Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Abstract: AIM-To assess the benefit of Lateral Pancreaticojejunostomy (LPJ) in patients wit

Big Data Analytics over Encrypted Datasets with Seabed

Today, enterprises collect large amounts of data and leverage the cloud to perform analytics over this data. Since the data is often sensitive, enterprises would prefer to keep it confidential and to hide it even from the cloud operator. Systems such as CryptDB and Monomi can accomplish this by operating mostly on encrypted data; however, these systems rely on expensive cryptographic techniques that limit performance in true “big data” scenarios that involve terabytes of data or more. This paper presents Seabed, a system that enables efficient analytics over large encrypted datasets. In contrast to previous systems, which rely on asymmetric encryption schemes, Seabed uses a novel, additively symmetric homomorphic encryption scheme (ASHE) to perform large-scale aggregations efficiently. Additionally, Seabed introduces a novel randomized encryption scheme called Splayed ASHE, or SPLASHE, that can, in certain cases, prevent frequency attacks based on auxiliary data

Oral Lichen Planus: An Update on Etiology, Pathogenesis and Management - A Review of Literature

Background: Lichen planus is a chronic inflammatory mucocutaneous disease. Mucosal lesions are classified into six clinical forms and there is malignant potential for Oral Lichen Planus (OLP); therefore, follow -up should be considered. There are many unestablished etiological factors for OLP. A genetic predisposition linked to Th, cytokine polymorphisms may promote the T cell-mediated immunological response to an induced antigenic change that is supposed to lead to OLP lesions. Some putative etiologic factors, mainly amalgam restorations and hepatitis C virus have been studied in detail. The diagnosis of OLP can be made from the clinical features if they are sufficiently characteristic, but biopsy is recommended to confirm the diagnosis, exclude dysplasia and malignancy and if active treatment is required. The aims of current OLP therapy are to eliminate mucosal erythema and ulceration, alleviate symptoms and reduce the risk of oral cancer. The management of OLP is mainly aimed at controlling the symptoms and topical immunomodulators such as powerful corticosteroids and calcineurin inhibitors have been used. However their long-term effects needs to be better explained and understood