Linfoma renal primário bilateral em cão - relato de caso

Due to the increase in the life expectancy of pets, the incidence of diseases associated with senility, such as neoplasms, has been increasing. Among them, lymphoma stands out, representing about 20% of all canine tumors and 90% of hematopoietic neoplasms. Anatomically, lymphoma can present in multicentric form, more common in dogs, mediastinal or thymic, alimentary, cutaneous or extranodal. In extranodal form, a primary lymphoid tumor occurs in any location outside the lymphatic system. Renal lymphomas are common in the multicentric form of the disease, but reports of primary renal lymphoma in dogs are limited. The clinical signs in patients with renal lymphoma are nonspecific, and apathy, vomiting, polyuria, polydipsia and hyporexia may occur. Most patients have renomegaly, abdominal pain, hypertension and azotemia. Nephrectomy is recommended in cases of unilateral lymphoma associated with systemic chemotherapy. However, even with chemotherapy, primary renal lymphoma usually has an unfavorable prognosis. The objective of this work is to describe a case of a canine, eight years old, with ultrasound kidney changes compatible with the neoplastic process. The diagnosis of bilateral primary renal lymphoma was confirmed post-mortem based on the result of cytological evaluation and the absence of involvement of other anatomical sites.Com o aumento da expectativa de vida dos animais de companhia, a incidência de doenças associadas à senilidade, como neoplasias, vem aumentando. Entre elas, destaca-se o linfoma, representando cerca de 20% de todos os tumores caninos e 90% das neoplasias hematopoiéticas. Anatomicamente, o linfoma pode se apresentar na forma multicêntrica, mais comum nos cães, mediastinal ou tímica, alimentar, cutânea ou extranodal. Na forma extranodal, ocorre presença de tumor linfoide primário em qualquer local fora do sistema linfático. Linfomas renais são comuns na forma multicêntrica da doença, porém os relatos de linfoma renal primário em cães são limitados. Os sinais clínicos em pacientes com linfoma renal são inespecíficos, podendo ocorrer apatia, vômito, poliúria, polidipsia e hiporéxia. A maioria dos pacientes possuem renomegalia, dor à palpação abdominal, hipertensão e azotemia. A nefrectomia é recomendada nos casos de linfoma unilateral associada a quimioterapia sistêmica. Entretanto, mesmo com o tratamento quimioterápico, o linfoma renal primário normalmente possui um prognóstico desfavorável. O objetivo deste trabalho é descrever um caso de um canino, de oito anos de idade, com alterações renais ultrassonográficas compatíveis com processo neoplásico, sendo confirmado o diagnóstico de linfoma renal primário bilateral post mortem a partir do resultado de avaliação citológica e ausência de acometimento de outros sítios anatômicos.2022-02-1

The (in)dependence of alternative splicing and gene duplication.

Alternative splicing (AS) and gene duplication (GD) both are processes that diversify the protein repertoire. Recent examples have shown that sequence changes introduced by AS may be comparable to those introduced by GD. In addition, the two processes are inversely correlated at the genomic scale: large gene families are depleted in splice variants and vice versa. All together, these data strongly suggest that both phenomena result in interchangeability between their effects. Here, we tested the extent to which this applies with respect to various protein characteristics. The amounts of AS and GD per gene are anticorrelated even when accounting for different gene functions or degrees of sequence divergence. In contrast, the two processes appear to be independent in their influence on variation in mRNA expression. Further, we conducted a detailed comparison of the effect of sequence changes in both alternative splice variants and gene duplicates on protein structure, in particular the size, location, and types of sequence substitutions and insertions/deletions. We find that, in general, alternative splicing affects protein sequence and structure in a more drastic way than gene duplication and subsequent divergence. Our results reveal an interesting paradox between the anticorrelation of AS and GD at the genomic level, and their impact at the protein level, which shows little or no equivalence in terms of effects on protein sequence, structure, and function. We discuss possible explanations that relate to the order of appearance of AS and GD in a gene family, and to the selection pressure imposed by the environment

Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children

International audienc

All-day school: Perspectives from education science and practice

Ganztagsschulen werden im pädagogischen Diskurs gefordert, weil das Mehr an Zeit die Möglichkeit gibt die "Schule neu zu denken" (Hartmut von Hentig). Unsicherheit besteht vielerorts bei der Frage nach der Ausgestaltung der ganztägigen Schulorganisation. In diesem Band geben Praktiker und Wissenschaftler Hinweise, wie eine Ganztagsschule gelingen kann. Der Band richtet sich an Interessierte aus Schule, Schulverwaltung, Wissenschaft und Studium. Inhaltsverzeichnis: Teil I: Perspektiven aus der Wissenschaft Olaf-Axel Burow Ganztagsschule entwickeln: Durch die „Weisheit der Vielen“ von der Unterrichtsanstalt zum Kreativen Feld Gerhard Koller Ganztagsschulen als Chance für die Entwicklung lokaler Bildungsregionen Fritz-Ulrich Kolbe Zur Entwicklung der Lern- und Unterrichtskultur in ganztägigen Angeboten: Erste Ergebnisse der LUGS-Studie Thomas Schnetzer Tagesstruktur an Ganztagsschulen: Die Rhythmisierung Christian Nerowski Die Tagesschule als Modell der Zeitstrukturierung durch Umverteilung des Unterrichts Ilse Kamski Hausaufgaben – Schulaufgaben – Lernzeiten: Ein Perspektivenwechsel Lars Holm Die Kooperation zwischen Ganztagsschulen und Eltern in Dänemark: Herausforderungen und Möglichkeiten Lea Pulkkinen/Raija Pirttimaa Der „integrierte Schultag“ in Finnland Teil II: Perspektiven aus der Praxis Alfred Hinz Schule ist Stätte der Personwerdung, was sonst? Ein Plädoyer für die Ganztagsschule am Beispiel der Bodensee-Schule St. Martin Christine Modesto Die offene Ganztagsschule in Bayern Claudia Gantke Die gebundene Ganztagsschule in Bayern Peter Hottaß Ganztagsschule: Von der Planung zur Umsetzung Andreas Keim Das Konzept des Achtjährigen Ganztagsgymnasiums am Beispiel des Johann-Philipp-von-Schönborn-Gymnasiums in Münnerstadt Karin Doberer Optimierte Raumbedingungen zur Unterstützung von Schulklima und Lernkultur Safter Çinar Können Ganztagsschulen Kinder und Jugendliche mit Migrationshintergrund besser fördern? Stephan Bloße Schulinterne Evaluation ganztägiger Angebote Sabine Brendel/Judith Strohm Das Programm „Ideen für Mehr! Ganztägig lernen“: Bedarfsorientierte Unterstützung von Ganztagsschulen"In the German educational discourse, all-day schools are demanded because the extra time provides the opportunity to "re-think school" ("die Schule neu denken", Hartmut von Hentig). In many schools, there is uncertainty in questions of the arrangement of the daily routine. In this book, researchers and practitioners indicate how an all-day school may succeed. The publication adresses interested people from school, school administration, education research and education studies.

Blau Syndrome-Associated Uveitis:Preliminary Results From an International Prospective Interventional Case Series

Purpose Provide baseline and preliminary follow-up results in a 5-year longitudinal study of Blau syndrome. Design Multicenter, prospective interventional case series. Methods Baseline data from 50 patients from 25 centers worldwide, and follow-up data for patients followed 1, 2, or 3 years at the end of study enrollment. Ophthalmic data were collected at baseline and yearly visits by means of a standardized collection form. Results Median age at onset of eye disease was 60 months and duration of eye disease at baseline 145 months. At baseline 38 patients (78%) had uveitis, which was bilateral in 37 (97%). Eight patients (21%) had moderate to severe visual impairment. Panuveitis was found in 38 eyes (51%), with characteristic multifocal choroidal infiltrates in 29 eyes (39%). Optic disc pallor in 9 eyes (12%) and peripapillary nodules in 9 eyes (12%) were the commonest signs of optic nerve involvement. Active anterior chamber inflammation was noted in 30 eyes (40%) at baseline and in 16 (34%), 17 (57%), and 11 (61%) eyes at 1, 2, and 3 years, respectively. Panuveitis was associated with longer disease duration. At baseline, 56 eyes (75%) were on topical corticosteroids. Twenty-six patients (68%) received a combination of systemic corticosteroids and immunomodulatory therapy. Conclusions Blau uveitis is characterized by progressive panuveitis with multifocal choroiditis, resulting in severe ocular morbidity despite continuous systemic and local immunomodulatory therapy. The frequency and severity of Blau uveitis highlight the need for close ophthalmologic surveillance as well as a search for more effective therapies

American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus

10.1002/acr.23834ARTHRITIS CARE & RESEARCH715579-59

The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes

Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics

The (In)dependence of Alternative Splicing and Gene Duplication.

Alternative splicing (AS) and gene duplication (GD) both are processes that diversify the protein repertoire. Recent examples have shown that sequence changes introduced by AS may be comparable to those introduced by GD. In addition, the two processes are inversely correlated at the genomic scale: large gene families are depleted in splice variants and vice versa. All together, these data strongly suggest that both phenomena result in interchangeability between their effects. Here, we tested the extent to which this applies with respect to various protein characteristics. The amounts of AS and GD per gene are anticorrelated even when accounting for different gene functions or degrees of sequence divergence. In contrast, the two processes appear to be independent in their influence on variation in mRNA expression. Further, we conducted a detailed comparison of the effect of sequence changes in both alternative splice variants and gene duplicates on protein structure, in particular the size, location, and types of sequence substitutions and insertions/deletions. We find that, in general, alternative splicing affects protein sequence and structure in a more drastic way than gene duplication and subsequent divergence. Our results reveal an interesting paradox between the anticorrelation of AS and GD at the genomic level, and their impact at the protein level, which shows little or no equivalence in terms of effects on protein sequence, structure, and function. We discuss possible explanations that relate to the order of appearance of AS and GD in a gene family, and to the selection pressure imposed by the environment