Time and Reference Systems

Geodesy is the science of the measurement and mapping of the Earth’s surface, and in this context it is also the science that defines and realizes coordinates and associated coordinate systems. Geodesy thus is the foundation for all applications of global navigation satellite system (GNSS). This chapter presents the reference systems needed to describe coordinates of points on the Earth’s surface or in near space and to relate coordinate systems among each other, as well as to some absolute system, visually, a celestial system. The topic is primarily one of geometry, but the geodynamics of the Earth as a rotating body in the solar system plays a fundamental role in defining and transforming coordinate systems. Therefore, also the fourth coordinate, time, is critical not only as the independent variable in the dynamical theories, but also as a parameter in modern geodetic measurement systems. Instead of expounding the theory of geodynamics and celestial mechanics, it is sufficient for the purpose of this chapter to describe the corresponding phenomena, textually, analytically and illustratively, in order to give a sense of the scope of the tasks involved in providing accurate coordinate reference systems not just to geodesists, but to all geoscientists

Identification of genes required for eye development by high-throughput screening of mouse knockouts.

Despite advances in next generation sequencing technologies, determining the genetic basis of ocular disease remains a major challenge due to the limited access and prohibitive cost of human forward genetics. Thus, less than 4,000 genes currently have available phenotype information for any organ system. Here we report the ophthalmic findings from the International Mouse Phenotyping Consortium, a large-scale functional genetic screen with the goal of generating and phenotyping a null mutant for every mouse gene. Of 4364 genes evaluated, 347 were identified to influence ocular phenotypes, 75% of which are entirely novel in ocular pathology. This discovery greatly increases the current number of genes known to contribute to ophthalmic disease, and it is likely that many of the genes will subsequently prove to be important in human ocular development and disease

Author Correction: Identification of genes required for eye development by high-throughput screening of mouse knockouts (Communications Biology, (2018), 1, 1, (236), 10.1038/s42003-018-0226-0).

This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply. In the original published version of the article, Valerie Vancollie was mistakenly omitted from the list of members of the International Mouse Phenotyping Consortium. In addition, recognition of funding from Wellcome Trust grant WT098051 was mistakenly omitted from the Acknowledgements.The errors have been corrected in both the PDF and HTML versions of the paper

Reappraisal of Austrosaurus mckillopi Longman, 1933 from the Allaru Mudstone of Queensland, Australia’s first named Cretaceous sauropod dinosaur

Austrosaurus mckillopi Longman, 1933 was the first Cretaceous sauropod reported from Australia, and the first Cretaceous dinosaur reported from Queensland (northeast Australia). This sauropod taxon was established on the basis of several fragmentary presacral vertebrae (QM F2316) derived from the uppermost Lower Cretaceous (upper Albian) Allaru Mudstone, at a locality situated 77 km west-northwest of Richmond, Queensland. Prior to its rediscovery in 2014, the type site was considered lost after failed attempts to relocate it in the 1970s. Excavations at the site in 2014 and 2015 led to the recovery of several partial dorsal ribs and fragments of presacral vertebrae, all of which clearly pertained to a single sauropod dinosaur. The discovery of new material belonging toof the type individual of Austrosaurus mckillopi, in tandem with a reassessment of the type seriesmaterial collected in the 1930s, has facilitated the rearticulation of the specimen. The resultant vertebral series comprises six presacral vertebrae—the posteriormost cervical and five anteriormost dorsals—in association with five left dorsal ribs and one right one. The fragmentary nature of the type specimen has historically hindered assessments of the phylogenetic affinities of Austrosaurus, as has the fact that these evaluations were often based on a subset of the type material. The reappraisal of the type series of Austrosaurus presented herein, on the basis of both external morphology and internal morphology visualised through CT data, validates it as a diagnostic titanosauriform taxon (, tentatively placed in Somphospondyli),, and characterised by the possession of an accessory lateral pneumatic foramen on dorsal vertebra I (a feature which appears to be autapomorphic) and by the presence of a robust ventral midline ridge on the centra of dorsal vertebrae I and II. The interpretation of the anteriormost preserved vertebra in Austrosaurus as a posterior cervical has also prompted the re-evaluation of an isolated, partial, posterior cervical vertebra (QM F6142, the “Hughenden sauropod”) derived from the upper Albian Toolebuc Formation (which underlies the Allaru Mudstone). Although this vertebra preserves an apparent unique character of its own (a spinopostzygapophyseal lamina fossa), it is not able to be referred unequivocally to Austrosaurus and is retained as Titanosauriformes indet. Austrosaurus mckillopi is one of the oldest known sauropods from the Australian Cretaceous based on skeletal remains, and potentially provides phylogenetic and/or palaeobiogeographic context for later taxa such as Wintonotitan wattsi, Diamantinasaurus matildae and Savannasaurus elliottorum