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Cardiac imaging in women: use of radionuclide myocardial perfusion imaging and echocardiography for acute chest pain
Evidence for the value of noninvasive cardiac imaging in patients for the detection of ischemic heart disease has traditionally come from trials using male patients. The application of such technology for women is often presumptive. Because there is an overall lower prevalence of ischemic heart disease in women, difference in body habitus, and smaller heart size, cardiac imaging in women presents unique challenges for imaging specialists and cardiologists. With the introduction of technetium-99 meters perfusion agents, gated single-photon emission computed tomography, and attenuation correction, myocardial perfusion imaging (MPI) in women has achieved a high sensitivity and specificity for the detection of coronary artery disease similar to that observed in men. With harmonic imaging and myocardial contrast agents, two-dimensional echocardiography offers comparable diagnostic accuracy in women. More importantly, MPI and stress echocardiography have prognostic value in predicting future cardiovascular events. The severity and extent of the single-photon emission computed tomography myocardial perfusion defects independently predict future cardiovascular events. Myocardial perfusion rest imaging during acute chest pain has a 99% negative predictive value of subsequent cardiovascular events, and a positive study MPI is the most important predictor for future cardiac events. Both MPI and stress echocardiography can direct high-risk patients to more invasive management or selectively identify lower-risk patients, allowing safe discharge from the emergency department and unnecessary hospitalization. Using a triage approach incorporating MPI or rest echocardiography in patients with acute chest pain results in significant cost savings. However, data on rest imaging in women during acute chest pain are still lacking
Imaging for Native Mitral Valve Surgical and Transcatheter Interventions
There has been rapid progress in transcatheter therapies for mitral regurgitation. These developments have elevated the need for the imager to have a core understanding of the functional mitral valve anatomy. Pre- and intraoperative echocardiography for surgical mitral valve repair for mitral regurgitation has defined contemporary interventional imaging in many ways. The central tenets of these principles apply to interventional imaging of transcatheter mitral valve interventions. However, the heightened emphasis on procedural planning and procedural imaging is one of the new challenges posed by transcatheter interventions. This need for accurate and reliable information has required the imager to be agnostic to the imaging modality. Cardiac computed tomography has become critical in procedural planning in this new paradigm. The expanded use of pre-procedural cardiac magnetic resonance to quantify mitral regurgitation and characterize the left ventricle is another illustration of this newer approach. Other illustrations of the new world of interventional imaging include the expanded use of 3-dimensional (3D) transesophageal echocardiography and real-time fusion of echocardiography and fluoroscopy images. Imaging data are also the basis for computational modeling, 3D printing, and artificial intelligence. These technologies are being increasingly explored to improve therapy selection and prediction of procedural outcomes. This review provides an update of the essentials in present interventional imaging for surgical and transcatheter interventions for mitral regurgitation