ヒト肝細胞の三次元培養による機能発現メカニズムに関する研究

博士（工学）崇城大

Gravitational structure formation in scale relativity

In the framework of the theory of scale relativity, we suggest a solution to the cosmological problem of the formation and evolution of gravitational structures on many scales. This approach is based on the giving up of the hypothesis of differentiability of space-time coordinates. As a consequence of this generalization, space-time is not only curved, but also fractal. In analogy with Einstein's general relativistic methods, we describe the effects of space fractality on motion by the construction of a covariant derivative. The principle of equivalence allows us to write the equation of dynamics as a geodesics equation that takes the form of the equation of free Galilean motion. Then, after a change of variables, this equation can be integrated in terms of a gravitational Schrodinger equation that involves a new fundamental gravitational coupling constant, alpha_{g} = w_{0}/c. Its solutions give probability densities that quantitatively describe precise morphologies in the position space and in the velocity space. Finally the theoretical predictions are successfully checked by a comparison with observational data: we find that matter is self-organized in accordance with the solutions of the gravitational Schrodinger equation on the basis of the universal constant w_{0}=144.7 +- 0.7 km/s (and its multiples and sub-multiples), from the scale of our Earth and the Solar System to large scale structures of the UniverseComment: 34 pages, 42 figures. Higher quality figures adde

Determination of Iodide and Idoxuridine at a Glutaraldehyde-Cross-Linked Poly-L-Lysine Modified Glassy Carbon Electrode

The detection limit (about 0.017 mu g mL(-1)) for voltammetric determination of iodide (peak at +0.87 V vs. Ag/AgCl at pH 2) at a glutaraldehyde-cross-linked poly-L-lysine modified glassy carbon electrode involving oxidation to iodine was found to be several orders of magnitude lower than that for the voltammetric determination on a bare glassy carbon electrode. This method was applied successfully to the determination of iodide in two medicinal formulations. Idoxuridine was determined indirectly at the same electrode by accumulating it first at -0.8 V vs. Ag/AgCl. At this potential the C-I bond in the adsorbed idoxuridine is reduced giving iodide, which is then determined at the modified electrode. The method was successfully applied to the determination of idoxuridine in a urine sample