Detection of air within the northern hemisphere polar vortex at Wakkanai and at Tsukuba, Japan

Intensive ozonesonde observations were conducted at Wakkanai(45.4°N , 141.7°E ), the northernmost city of Japan, during the period 15th to 24th February 2001. Air in the polar vortex passed over Wakkanai on 19th February 2001 on the 700K isentropic surface. An increase of potential vorticity and a decrease of ozone mixing ratio on the 700K isentropic surface over Wakkanai were observed on the same day, 19th February 2001. On the other hand, on the 450K isentropic surface the air in the polar vortex passed over Tsukuba(36.1°N , 140.1°E ), Japan, where the Aerological Observatory and the Meteorological Research Institute are located, on 20th February 2001. Decrease of the ratio of observed HCl(hydrogen chloride) to HCl estimated from HF(hydrogen fluoride) and increases of the potential vorticity and ozone mixing ratio on the 450K isentropic surface were observed over Tsukuba on 20th February 2001. These facts indicate that the polar vortex passed over Tsukuba on the 450K isentropic surface on 20th February 2001. Observations show that the polar vortex on the 700K isentropic surface existed over Europe and Siberia on 14th February 2001 moved eastward, and reached Wakkanai, Japan on 19th February 2001. Observations also show that the polar vortex on the 450K isentropic surface found over Europe and Siberia on the 14th moved eastward and reached Wakkanai, Japan between 15th and 20th February 2001 and covered Tsukuba, Japan on 20th February 2001. The ozone mixing ratio derived from ozonesonde data shows the possibility of decrease of ozone mixing ratio with ozone destructive chemical reactions in the northern hemisphere polar vortex on the 450K isentropic surface

Report on the method for determining the location of the polar vortex boundary region

To determine the boundary region of the polar vortex objectively using the PV distribution on isentropic surfaces, the equivalent latitude(Eql) of the polar vortex boundary was calculated using a slightly modified form of the technique of E.R. Nash et al.(J. Geophys. Res., 101D, 9471, 1996). Using the NCEP/NCAR reanal- ysis data, the Eql of the polar vortex boundary region in the winter of 1999/2000 was calculated, and compared with the ozone mixing ratio in the lower stratosphere over Eureka observatory(80°N , 86°W ). The results indicate that this method determines the boundary region of the polar vortex well

Ozone recovery in the upper stratosphere from Umkehr measurement over Syowa, Antarctica

第3回極域科学シンポジウム/第35回極域気水圏シンポジウム 11月30日（金） 国立国語研究所 ２階ロビ

Apparent stratospheric ozone loss rate over Eureka in 1994/95, 1995/96, and 1996/97 inferred from ECC ozonesonde observations

Many ECC-type ozonesondes were launched at the Canadian Arctic Eureka observatory(80°N , 86°W ), one of the most northern stations in the Arctic, during winters from 1993/94 to 2001/02, and the temporal evolutions of the vertical ozone profiles were obtained in detail. The lower stratospheric temperature over Eureka was very low inside the polar vortex and the largest ozone loss was observed in 1999/2000, as reported in a previous paper. Similarly, Eureka was often or persistently inside the vortex in the lower stratosphere(around the 470K isentropic surface level) in the winters of 1994/95, 1995/96, and 1996/97. Very low temperatures were observed inside the vortex in the lower stratosphere over Eureka, as indicated by detection of PSCs by Mie lidar. Observations of tracers(N_2O, total reactive nitrogen species(NOy), and others) inside the vortex during these winters using an ER-2 aircraft and balloons indicated that the effect of air parcel mixing across the vortex edge was minimal, based on the tracer-tracer relationship(e.g., Y. Kondo et al.; J. Geophys. Res., 104D, 8215, 1999). Therefore, significant decreases of the in-travortex ozone mixing ratio in the lower stratosphere were considered to be chemical ozone losses due to chlorine activation of PSCs following diabatic descent. The apparent ozone loss rate inside the vortex over Eureka was estimated for each year. The rates ranged from 0.01 to 0.03ppmv/day, less than that observed in 1999/2000(0.04ppmv/day). The observations were conducted at a single station; however, the apparent ozone loss rate over Eureka inside the vortex each year agrees with loss rates obtained in other studies

Long term changes in the upper stratospheric ozone at Syowa, Antarctica

第2回極域科学シンポジウム/第35回極域宙空圏シンポジウム 11月15日（火） 国立極地研究所 2階大会議

Laparoscopic Splenectomy Using a Low-pressure Pneumoperitoneum for the Treatment of Immune Thrombocytopenic Purpura During Pregnancy : A Case Report

Article信州医学雑誌 62(6):441-446(2014)journal articl

血清TARC/CCL17値は薬剤性過敏症症候群(DIHS) の早期診断および病勢の指標となりうる。

BACKGROUND:Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a serious acute drug reaction with fever, cutaneous eruption, lymphadenopathy, and several visceral dysfunctions. Eosinophilia is a common hematological abnormality in DIHS/DRESS suggesting that the Th2-type immune response is involved. Thymus and activation-regulated chemokine (TARC/CCL17) is a family of CC chemokines known to play an important role in Th2-mediated immune-inflammatory processes. OBJECTIVE:We investigated the pathogenic role of TARC in patients with DIHS. METHODS:Sera were obtained from 8 patients with DIHS, 7 patients with Stevens-Johnson syndrome/Toxic epidermal necrolysis (SJS/TEN), and 14 patients with drug-induced maculopapular exanthema (MPE). Serum TARC levels were measured by ELISA. TARC levels were then compared with clinical symptoms and various hematological parameters. In addition, a biopsy was taken from the lesional skin of patients with DIHS and stained with anti-TARC Ab and anti-CD11c Ab. RESULTS:Serum TARC levels in patients with DIHS were significantly higher than those in patients with SJS/TEN and MPE during the acute phase. Serum TARC levels in DIHS patients correlated with skin eruptions, serum sIL-2R levels, eosinophil counts, and serum IL-5 levels. Immunohistochemical staining revealed that TARC was mainly expressed on CD11c+ dermal dendritic cells in patients with DIHS. CONCLUSION:Serum TARC levels may be associated with the initial presentation of DIHS as well as disease activity during the course. Thus, they could be useful as an indicator for early diagnosis and assessment of disease activity in DIHS. CD11c+ dendritic cells may be the main source of TARC in patients with DIHS.博士（医学）・甲第597号・平成25年3月15日Copyright © 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved