Gravitational waves from first order electroweak phase transition in models with the U(1)XU(1)_X^{} gauge symmetry

We consider a standard model extension equipped with a dark sector where the $U(1)_X^{}$ Abelian gauge symmetry is spontaneously broken by the dark Higgs mechanism. In this framework, we investigate patterns of the electroweak phase transition as well as those of the dark phase transition, and examine detectability of gravitational waves (GWs) generated by such strongly first order phase transition. It is pointed out that the collider bounds on the properties of the discovered Higgs boson exclude a part of parameter space that could otherwise generate detectable GWs. After imposing various constraints on this model, it is shown that GWs produced by multi-step phase transitions are detectable at future space-based interferometers, such as LISA and DECIGO, if the dark photon is heavier than 25 GeV. Furthermore, we discuss the complementarity of dark photon searches or dark matter searches with the GW observations in these models with the dark gauge symmetry.Comment: 23 pages, 22 figures, version published in Journal of High Energy Physic

Iron Chelation Therapy with Deferasirox Results in Improvement of Liver Enzyme Level in Patients with Iron Overload-Associated Liver Dysfunction

Iron chelation therapy (ICT) has been applied for the patients with iron overload-associated liver dysfunction since it is one of the causes of death in patients with intractable hematological diseases requiring multiple red blood cell transfusions. Recently, deferasirox (DSX), a novel, once-daily oral iron chelator, was demonstrated to have similar efficacy to the conventional continuous infusion of deferoxamine on a decrease in serum ferritin (SF) level in heavily transfused patients. We show three cases of transfusion-mediated iron-overloaded patients with an elevated serum alanine aminotransaminase (ALT). All three patients who received the ICT with DSX showed a decrease in ALT level in association with a decrease in SF level. It is suggested that DSX therapy could be considered to expect the improvement of liver damage for iron-overloaded patients with an abnormal ALT level

SAEB: A Lightweight Blockcipher-Based AEAD Mode of Operation

Lightweight cryptography in computationally constrained devices is actively studied. In contrast to advances of lightweight blockcipher in the last decade, lightweight mode of operation is seemingly not so mature, yet it has large impact in performance. Therefore, there is a great demand for lightweight mode of operation, especially that for authenticated encryption with associated data (AEAD). Among many known properties of conventional modes of operation, the following four properties are essential for constrained devices: 1. Minimum State Size: the state size equals to a block size of a blockcipher. 2. Inverse Free: no need for a blockcipher decryption. 3. XOR Only: only XOR is needed in addition to a blockcipher encryption. 4. Online: a data block is processed only once. The properties 1 and 4 contribute to small memory usage, and the properties 2 and 3 contribute to small program/circuit footprint. On top of the above properties, the fifth property regarding associated data (AD) is also important for performance: 5. Efficient Handling of Static AD: static AD can be precomputed. We design a lightweight blockcipher-based AEAD mode of operation called SAEB: the first mode of operation that satisfies all the five properties to the best of our knowledge. Performance of SAEB is evaluated in various software and hardware platforms. The evaluation results show that SAEB outperforms conventional blockcipher-based AEAD modes of operation in various performance metrics for lightweight cryptography

Hassall’s corpuscles induce thymic IFNα expression

Hassall’s corpuscles (HCs) are composed of cornifying, terminally differentiated medullary thymic epithelial cells (mTECs) that are developed under the control of Aire. Here, we demonstrated that HC-mTECs show features of cellular senescence and produce inflammatory cytokines and chemokines including CXCL5, thereby recruiting and activating neutrophils to produce IL-23 in the thymic medulla. We further indicated that thymic plasmacytoid dendritic cells (pDCs) expressing IL-23 receptors constitutively produced Ifna, which plays a role in single positive (SP) cell maturation, in an Il23a-dependent manner. Neutrophil depletion with anti-Ly6G antibody injection resulted in a significant decrease of Ifna expression in the thymic pDCs, suggesting that thymic neutrophil activation underlies the Ifna expression in thymic pDCs in steady state conditions. A New Zealand White mouse strain showing HC hyperplasia exhibited greater numbers and activation of thymic neutrophils and pDCs than B6 mice, whereas Aire-deficient B6 mice with defective HC development and SP thymocyte maturation showed significantly compromised numbers and activation of these cells. These results collectively suggested that HC-mTECs with cell-senescence features initiate a unique cell activation cascade including neutrophils and pDCs leading to the constitutive IFNα expression required for SP T-cell maturation in the thymic medulla

A New Species of the Fejervarya limnocharis Complex from Japan (Anura, Dicroglossidae)

We describe a new species of dicroglossid frog of the Fejervarya limnocharis complex from western Honshu, Japan Mainland. The new species, Fejervarya kawamurai, is genetically closer to F. sakishimensis than to F. limnocharis. It differs from F. sakishimensis by smaller tympanum, head, forelimb, hindlimb, foot, and tibia lengths, all relative to snout-vent length, and from F. multistriata by relatively shorter forelimb, hindlimb, foot, and tibia. From F. limnocharis and F. iskandari, it is differentiated by relatively smaller forelimb, hindlimb, foot, and tibia lengths. Taxonomic problems of Fejervarya populations occurring in Central Ryukyus, continental China, and Taiwan are discussed

A Pooled Analysis of Multicenter Cohort Studies of 123I-mIBG Imaging of Sympathetic Innervation for Assessment of Long-Term Prognosis in Heart Failure

ObjectivesThe study objectives were to create a cardiac metaiodobenzylguanidine (mIBG) database using multiple prospective cohort studies and to determine the quantitative iodine-123–labeled mIBG indices for identifying patients with chronic heart failure (HF) at greatest and lowest risk of lethal events.BackgroundAlthough the prognostic value of cardiac mIBG imaging in patients with HF has been shown, clinical use of this procedure has been limited. It is required to define universally accepted quantitative thresholds for high and low risk that could be used as an aid to therapeutic decision-making using a large cohort database.MethodsSix prospective HF cohort studies were updated, and the individual datasets were combined for the present patient-level analysis. The database consisted of 1,322 patients with HF followed up for a mean interval of 78 months. Heart-to-mediastinum ratio (HMR) and washout rate of cardiac mIBG activity were the primary cardiac innervation markers. The primary outcome analyzed was all-cause death.ResultsLethal events were observed in 326 patients, and the population mortality rate was 5.6%, 11.3%, and 19.7% at 1, 2, and 5 years, respectively. Multivariate Cox proportional hazard model analysis for all-cause mortality identified age (p < 0.0001), New York Heart Association (NYHA) functional class (p < 0.0001), late HMR of cardiac mIBG activity (p < 0.0001), and left ventricular ejection fraction (LVEF) (p = 0.0029) as significant independent predictors. Analysis of the 512-patient subpopulation with B-type natriuretic peptide (BNP) results showed BNP (p < 0.0001), greater NYHA functional class (p = 0.0002), and late HMR (p = 0.0011) as significant predictors, but LVEF was not. The receiver-operating characteristic–determined threshold of HMR (1.68) identified patients at significantly increased risk in any LVEF category. Survival rates decreased progressively with decreasing HMR, with 5-year all-cause mortality rates >7% annually for HMR <1.25, and <2% annually for HMR ≥1.95. Addition of HMR to clinical information resulted in a significant net reclassification improvement of 0.175 (p < 0.0001).ConclusionsPooled analyses of independent cohort studies confirmed the long-term prognostic value of cardiac mIBG uptake in patients with HF independently of other markers, such as NYHA functional class, BNP, and LVEF, and demonstrated that categoric assessments could be used to define meaningful thresholds for lethal event risk