Controlling intracoronary CT number for coronary CT angiography

AbstractBackgroundControlling intracoronary computed tomography (CT) number for coronary CT angiography (CCTA) has been difficult.ObjectiveThe study assessed whether intracoronary CT number of CCTA could be estimated.MethodsOne hundred twenty six patients were randomly assigned to either CCTA with 30mL of contrast media (CM) following 5mL of CM at timing bolus or CCTA with 50mL of CM following 10mL of CM at timing bolus. The relationships between intracoronary CT number and patients’ characteristics and peak time and peak CT number at timing bolus in patients who showed valid time–density curve were analyzed in both groups. Then, the multiple regression equation best described was made. The prediction system was validated by 112 patients randomly targeted between 250HU and 430HU of CT number.ResultsIn group 5/30, intracoronary CT number was positively correlated with peak CT number at timing bolus (correlation coefficient, 1.42, p<0.001), negatively correlated with body surface area (−109.19, p<0.001) and peak time (−6.93, p<0.001). Whereas, intracoronary CT number was positively correlated with only peak CT number at timing bolus (1.33, p<0.001) in group 10/50. Then, CT number-controlling system using the simple equation best described CT number was established for CCTA following 5mL of CM at timing bolus. Of 112 patients, there was good correlation between target CT number and measured CT number (r=0.85, p<0.0001) in 96 patients (85.7%), having valid time–density curve at timing bolus.ConclusionsControlling CT number may be enabled by CT number-controlling system following 5mL of CM at timing bolus