620 research outputs found
Budd-Chiari syndrome recurring in a transplanted liver
A patient with Budd-Chiari syndrome who underwent orthotopic liver transplantation and developed recurrent disease is described. The immediate postoperative period was complicated by multiple thrombotic episodes, followed by a period of apparent remission associated with the initiation of coumadin and persantine therapy. After discontinuation of such antithrombotic therapy in order to biopsy the liver, the patient experienced another series of clinically overt vascular thromboses and ultimately died of sepsis 15 mo posttransplantation after a prolonged and complicated terminal hospital course. At autopsy, recurrent Budd-Chiari syndrome as well as thromboses in numerous other organs was demonstrated. © 1983
The Clumping Transition in Niche Competition: a Robust Critical Phenomenon
We show analytically and numerically that the appearance of lumps and gaps in
the distribution of n competing species along a niche axis is a robust
phenomenon whenever the finiteness of the niche space is taken into account. In
this case depending if the niche width of the species is above or
below a threshold , which for large n coincides with 2/n, there are
two different regimes. For the lumpy pattern emerges
directly from the dominant eigenvector of the competition matrix because its
corresponding eigenvalue becomes negative. For the lumpy
pattern disappears. Furthermore, this clumping transition exhibits critical
slowing down as is approached from above. We also find that the number
of lumps of species vs. displays a stair-step structure. The positions
of these steps are distributed according to a power-law. It is thus
straightforward to predict the number of groups that can be packed along a
niche axis and it coincides with field measurements for a wide range of the
model parameters.Comment: 16 pages, 7 figures;
http://iopscience.iop.org/1742-5468/2010/05/P0500
Influence of solute doping on the high-temperature deformation behavior of GaAs
The role of isovalent dopants in the highâtemperature deformation of GaAs has been studied in the temperature range 500â1150â°C. Additions of In, Sb, and B increase the critical resolved shear stress for deformation at a given strain rate and result in lowering the dislocation density of asâgrown liquidâencapsulated Czochralski GaAs crystals. Phosphorus, because of its minor influence on the lattice strain, shows little enhancement of the yield stress. These results are consistent with a solute hardening model, in which the solute atom surrounded tetrahedrally by four Ga or As atoms comprise the hardening cluster. Codoping with In and Si hardens GaAs, but codoping with Si is less effective than the isovalent solutes In, Sb, and B, and produces softening at high temperatures. The effect of solutes on both dislocation nucleation and multiplication are reviewed here
A model for the induction of chromosome aberrations through direct and bystander mechanisms
A state vector model (SVM) for chromosome aberrations and neoplastic transformation has been adapted to describe detrimental bystander effects. The model describes initiation (formation of translocations) and promotion (clonal expansion and loss of contact inhibition of initiated cells). Additional terms either in the initiation model or in the rate of clonal expansion of initiated cells, describe detrimental bystander effects for chromosome aberrations as reported in the scientific literature. In the present study, the SVM with bystander effects is tested on a suitable dataset. In addition to the simulation of non-linear effects, a classical dataset for neoplastic transformation in C3H 10T1/2 cells after alpha particle irradiation is used to show that the model without bystander features can also describe LNT-like dose responses. A published model for bystander induced neoplastic transformation was adapted for chromosome aberration induction and used to compare the results obtained with the different models
The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model
While the infection rate of orthopedic implants is low, the required treatment, which can involve six weeks of antibiotic therapy and two additional surgical operations, is life threatening and expensive, and thus motivates the development of a one-stage re-implantation procedure. Polyelectrolyte multilayers incorporating gentamicin were fabricated using the layer-by-layer deposition process for use as a device coating to address an existing bone infection in a direct implant exchange operation. The films eluted about 70% of their payload in vitro during the first three days and subsequently continued to release drug for more than four additional weeks, reaching a total average release of over 550 ÎŒg/cm[superscript 2]. The coatings were demonstrated to be bactericidal against Staphylococcus aureus, and degradation products were generally nontoxic towards MC3T3-E1 murine preosteoblasts. Film-coated titanium implants were compared to uncoated implants in an in vivo S. aureus bone infection model. After a direct exchange procedure, the antimicrobial-coated devices yielded bone homogenates with a significantly lower degree of infection than uncoated devices at both day four (p < 0.004) and day seven (p < 0.03). This study has demonstrated that a self-assembled ultrathin film coating is capable of effectively treating an experimental bone infection in vivo and lays the foundation for development of a multi-therapeutic film for optimized, synergistic treatment of pain, infection, and osteomyelitis.National Institutes of Health (U.S.) (National Institute on Aging Grant 5R01AG029601-03
Silencing Heat Shock Protein 47 (HSP47) in Fibrogenic Precision-Cut Lung Slices:A Surprising Lack of Effects on Fibrogenesis?
Idiopathic pulmonary fibrosis (IPF) is a chronic disease that is characterized by the excessive deposition of scar tissue in the lungs. As currently available treatments are unable to restore lung function in patients, there is an urgent medical need for more effective drugs. Developing such drugs, however, is challenging because IPF has a complex pathogenesis. Emerging evidence indicates that heat shock protein 47 (HSP47), which is encoded by the gene Serpinh1, may be a suitable therapeutic target as it is required for collagen synthesis. Pharmacological inhibition or knockdown of HSP47 could therefore be a promising approach to treat fibrosis. The objective of this study was to assess the therapeutic potential of Serpinh1-targeting small interfering RNA (siRNA) in fibrogenic precision-cut lung slices prepared from murine tissue. To enhance fibrogenesis, slices were cultured for up to 144 h with transforming growth factor ÎČ1. Self-deliverable siRNA was used to knockdown mRNA and protein expression, without affecting the viability and morphology of slices. After silencing HSP47, only the secretion of fibronectin was reduced while other aspects of fibrogenesis remained unaffected (e.g., myofibroblast differentiation as well as collagen secretion and deposition). These observations are surprising as others have shown that Serpinh1-targeting siRNA suppressed collagen deposition in animals. Further studies are therefore warranted to elucidate downstream effects on fibrosis upon silencing HSP47
Measuring flushing symptoms with extended-release niacin using the flushing symptom questionnaire©: results from a randomised placebo-controlled clinical trial
Gauge invariance and finite width effects in radiative two-pion tau lepton decay
The contribution of the rho^{\pm} vector meson to the tau -> pi pi nu gamma
decay is considered as a potential source for the determination of the magnetic
dipole moment of this light vector meson. In order to keep gauge-invariance of
the whole decay amplitude, a procedure similar to the fermion loop-scheme for
charged gauge bosons is implemented to incorporate the finite width effects of
the rho^{\pm} vector meson. The absorptive pieces of the one-loop corrections
to the propagators and electromagnetic vertices of the rho^{\pm} meson and
W^{\pm} gauge boson have identical forms in the limit of massless particles in
the loops, suggesting this to be a universal feature of spin-one unstable
particles. Model-dependent contributions to the tau -> pi pi nu gamma decay are
suppressed by fixing the two-pion invariant mass distribution at the rho meson
mass value. The resulting photon energy and angular distribution is relatively
sensitive to the effects of the rho magnetic dipole moment.Comment: 22 pages, 4 postscript figures, references and comments on relevance
of perturbative treatment of rho electromagnetic vertex are added, accepted
for pub. in Phys. Rev.
A new Perspective on the Scalar meson Puzzle, from Spontaneous Chiral Symmetry Breaking Beyond BCS
We introduce coupled channels of Bethe-Salpeter mesons both in the boundstate
equation for mesons and in the mass gap equation for chiral symmetry.
Consistency is insured by the Ward Identities for axial currents, which
preserve the Goldstone boson nature of the pion and prevents a systematic shift
of the hadron spectrum. We study the decay of a scalar meson coupled to a pair
of pseudoscalars. We also show that coupled channels reduce the breaking of
chiral symmetry, with the same Feynman diagrams that appear in the coupling of
a scalar meson to a pair of pseudoscalar mesons. Exact calculations are
performed in a particular confining quark model, where we find that the
groundstate meson is the f_0(980) with a partial decay
width of 40MeV. We also find a 30% reduction of the chiral condensate due to
coupled channels.Comment: 17 pages, Revtex, 8 eps figures, and several eps diagrams in
equation
EPR, ESE and pulsed ENDOR study of nitrogen related centers in 4H-SiC wafers grown by different technologies
D-band electron paramagnetic resonance (EPR) measurements as well as X and Q-band field-swept Electron Spin Echo (ESE) and pulsed Electron Nuclear Double Resonance (ENDOR) studies were performed on a series of n-type 4H-SiC wafers grown by different techniques including sublimation sandwich method (SSM), physical vapor transport (PVT) and modified Lely method. Depending on the C/Si ratio and the growth temperature the n-type 4H-SiC wafers revealed, besides a triplet due to nitrogen residing on the cubic site (Nc), two nitrogen (N) related EPR spectra with g||=2.0055, gâ„=2.0010 and g||=2.0063, gâ„=2.0005 with different intensities. In the samples with low C/Si ratio the EPR spectrum with g||=2.0055, gâ„=2.0010 consists of a triplet with low intensity which is tentatively explained as a N-related complex, while in the samples with high C/Si ratio the triplet is transformed into one structureless line of high intensity, which is explained as being due to an exchange interaction between N donors. In the samples grown at low temperature with enhanced carbon concentration the EPR line with g||=2.0063, gâ„=2.0005 and a small hyperfine (hf) interaction dominates the EPR spectrum. It is attributed to N on the hexagonal lattice site. The interpretation of the EPR data is supported by activation energies and donor concentrations obtained from Hall effect measurements for three donor levels in this series of 4H-SiC samples
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