The Effects of Isoprene Emission from Native and Invasive Trees on Local Air Quality

Biogenic volatile organic compounds (BVOC) are the second-most abundant reactive gasses emitted into the atmosphere by the biosphere. Isoprene is a BVOC produced by the process of photosynthesis from vegetation and is emitted from plant leaves. Isoprene is a hydrocarbon that combines with oxides of nitrogen in the atmosphere to create ozone in the troposphere, an air pollutant. Invasive trees alter ecosystems and affect native tree populations. Invasive tree species in the Chicagoland area are outcompeting native tree species and expanding rapidly. The effect of isoprene emissions on air quality is a well-researched area in the atmospheric science community, however, the differing isoprene emission patterns between invasive and native trees in the Chicagoland area have not been studied in the literature. From the experiment, it was conclusive that there was no statistical difference in isoprene emissions between the most abundant native and invasive tree species in the same ecosystem, and hence an impact of invasive species on air quality was not demonstrated. However, it was clear that European buckthorn, invasive to Illinois, was a strong isoprene emitter

Tropospheric sounding with low-cost particulate matter sensors

The high-altitude balloon (HAB) platform has allowed scientists to measure vertical profiles in the atmosphere at a relatively low cost. The current project combines the HAB platform with low-cost air quality sensors that measure particulate matter (PM). PM is detrimental to human health and can exacerbate asthma. In the atmosphere, PM can affect cloud formation and also radiative transfer, which links emissions of PM to climate change. Therefore, understanding and controlling PM emissions is vital to air quality and climate change. In agricultural regions, several practices produce significant PM emissions. Tilling can release PM in the form of dust, especially under arid conditions. The burning of crop residue is also a common practice practice that releases PM in the form of partially combusted organics (soot). The ultimate goal of this project is to use low-cost PM sensors and HAB to assess PM sources from agricultural regions using citizen scientists. The current presentation evaluates the performance of two different PM sensors over flights conducted during the summer of 2017

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Tropospheric sounding with low-cost particulate matter sensors

The high-altitude balloon (HAB) platform has allowed scientists to measure vertical profiles in the atmosphere at a relatively low cost. The current project combines the HAB platform with low-cost air quality sensors that measure particulate matter (PM). PM is detrimental to human health and can exacerbate asthma. In the atmosphere, PM can affect cloud formation and also radiative transfer, which links emissions of PM to climate change. Therefore, understanding and controlling PM emissions is vital to air quality and climate change. In agricultural regions, several practices produce significant PM emissions. Tilling can release PM in the form of dust, especially under arid conditions. The burning of crop residue is also a common practice practice that releases PM in the form of partially combusted organics (soot). The ultimate goal of this project is to use low-cost PM sensors and HAB to assess PM sources from agricultural regions using citizen scientists. The current presentation evaluates the performance of two different PM sensors over flights conducted during the summer of 2017