The Ursinus Weekly, March 14, 1955

Dean Pettit explains makeup of Dean\u27s List, ineligibility • Campus Chest drive begins; Free blotters • Ursinus host to S. E. district FTA • Soph Shamrock shuffle Sat. • Messiah chorus presents records to Dr. Wm. Philip • Weary Chess Club drops 3rd, loses to F & M by 4 1/2 - 1/2 • Movie Symphonie pastorale to be presented Mar. 17, 18 • Records available • Gerald Hottenstein lists 10 musts for FTA group • My three angels cast chosen • Canterbury Club to visit Philadelphia Divinity School • First music seminar • Dr. Spurgeon English speaks on a second vocation at Forum • Levin elected head of \u2756 spirit group • Betty Tayes writes winning pageant • Plastic surgeons to address pre-med society tonight • Chi Alpha to discuss church fellowship • Junior prom Spring coronation at Sunnybrook on April 22 • A.P.O. strongmen begin conservation project • Sorority news • Are training tables necessary? • Y intercollegiate meeting yesterday • Gals rout Penn 76-43, Kuhn, Gros garner 62 • Bird belles score 3-2 win at Bryn Mawr • Beaver edges UC mermaids in 31-26 tilt • Owl timekeeper blamed for 48-48 court farce • Dawkins, Padula to take mats in AAU\u27s nationals • Ted Sholl tallies 24 points as Curtis I cops intramural title • Baseball coming attractionshttps://digitalcommons.ursinus.edu/weekly/1469/thumbnail.jp

The Ursinus Weekly, March 14, 1955

Dean Pettit explains makeup of Dean\u27s List, ineligibility • Campus Chest drive begins; Free blotters • Ursinus host to S. E. district FTA • Soph Shamrock shuffle Sat. • Messiah chorus presents records to Dr. Wm. Philip • Weary Chess Club drops 3rd, loses to F & M by 4 1/2 - 1/2 • Movie Symphonie pastorale to be presented Mar. 17, 18 • Records available • Gerald Hottenstein lists 10 musts for FTA group • My three angels cast chosen • Canterbury Club to visit Philadelphia Divinity School • First music seminar • Dr. Spurgeon English speaks on a second vocation at Forum • Levin elected head of \u2756 spirit group • Betty Tayes writes winning pageant • Plastic surgeons to address pre-med society tonight • Chi Alpha to discuss church fellowship • Junior prom Spring coronation at Sunnybrook on April 22 • A.P.O. strongmen begin conservation project • Sorority news • Are training tables necessary? • Y intercollegiate meeting yesterday • Gals rout Penn 76-43, Kuhn, Gros garner 62 • Bird belles score 3-2 win at Bryn Mawr • Beaver edges UC mermaids in 31-26 tilt • Owl timekeeper blamed for 48-48 court farce • Dawkins, Padula to take mats in AAU\u27s nationals • Ted Sholl tallies 24 points as Curtis I cops intramural title • Baseball coming attractionshttps://digitalcommons.ursinus.edu/weekly/1469/thumbnail.jp

The Ursinus Weekly, November 9, 1953

Palmer to speak on U.S. and India Wednesday night • Campus Chest opens contest • MSGA hears cheating case; WSGA meeting held Monday • A tradition dies, buried in snow • Newbury discusses Argentina in Ursinus class Wednesday • Barbershop quartet program postponed until November 13 • Group play deemed success by reviewer • Alumnus talks on anesthesia to pre-med society • Shades of indigo to be prom theme • Head of E. and R. Church is Founders Day speaker • IRC to hear guest speaker • Pledgees sign fraternity bids • Helena\u27s husband is group II presentation • 1955 Ruby editors are Dedekind, Belz • Chem society hears talk on Laminar chart • Pre-legal society to sponsor debate on red China in UN • 100 contribute to fill Ursinus bloodmobile quota • Editorials: Open letter to the Weekly staff • This week: Friday the 13th • Letters to the editor • Unexpected snow causes unusual weekend antics • I-F Council adopts new rule on rushing • Soccer team loses to Haverford, 3-2https://digitalcommons.ursinus.edu/weekly/1482/thumbnail.jp

The Ursinus Weekly, April 13, 1953

Committee selects YMCA nominees; Profs speak Wed. • May Day pageant has monthly theme • Ursinus entertains Hi-Y • Weekly staff hears C. Lee • Curtain Club prepares for Spring production • Dr. C. L. Chandler heard as speaker at IRC banquet • Fotine to play for Jr. dance • High class stuff to be given by junior class, April 17-18 • Candidates revealed for WSGA, WAA, YWCA • Iranian diplomat speaks to forum • Model UN held at Cornell; Dr. Miller advises committee • 35 students eligible to join Pi Gamma Mu • WAA card party tonight • Editorials: Procedure is important • Fry\u27s play well done by Curtain Club group • Dinner dances planned at sorority meetings • Boys\u27 quartet visits Temple • Letters to the editor • Mixed marriages • Juniors adopt new policies in prom plans • For all young lovers on rainy Spring days, suggested: Exciting tour through Pfahler Hall • Freidlin, Syvertsen elected basketball, swimming captains; Belles fall to Temple and defeat boys in thrillers • Kenny captains men\u27s tennis • Swett leads track team; Eshbach, Weaver return • Boyd and Rittenhouse captain girls\u27 tennis • Intramural wins to Derr, Ehlers • Baseball season opens; Veterans bolster team • Meistersingers give concert, plan program for April 23https://digitalcommons.ursinus.edu/weekly/1516/thumbnail.jp

Approaching Artificial Intelligence in Orthopaedics. Predictive Analytics and Machine Learning to Prognosticate Arthroscopic Rotator Cuff Surgical Outcomes

Machine learning (ML) has not yet been used to identify factors predictive for post-operative functional outcomes following arthroscopic rotator cuff repair (ARCR). We propose a novel algorithm to predict ARCR outcomes using machine learning. This is a retrospective cohort study from a prospectively collected database. Data were collected from the Surgical Outcome System Global Registry (Arthrex, Naples, FL, USA). Pre-operative and 3-month, 6-month, and 12-month post-operative American Shoulder and Elbow Surgeons (ASES) scores were collected and used to develop a ML model. Pre-operative factors including demography, comorbidities, cuff tear, tissue quality, and fixation implants were fed to the ML model. The algorithm then produced an expected post-operative ASES score for each patient. The ML-produced scores were compared to actual scores using standard test-train machine learning principles. Overall, 631 patients who underwent shoulder arthroscopy from January 2011 to March 2020 met inclusion criteria for final analysis. A substantial number of the test dataset predictions using the XGBoost algorithm were within the minimal clinically important difference (MCID) and substantial clinical benefit (SCB) thresholds: 67% of the 12-month post-operative predictions were within MCID, while 84% were within SCB. Pre-operative ASES score, pre-operative pain score, body mass index (BMI), age, and tendon quality were the most important features in predicting patient recovery as identified using Shapley additive explanations (SHAP). In conclusion, the proposed novel machine learning algorithm can use pre-operative factors to predict post-operative ASES scores accurately. This can further supplement pre-operative counselling, planning, and resource allocation. Level of Evidence: III

Cell-free stem cell-derived extract formulation for treatment of knee osteoarthritis: study protocol for a preliminary non-randomized, open-label, multi-center feasibility and safety study.

BACKGROUND: Musculoskeletal conditions are highly prevalent, and knee OA is most common. Current treatment modalities have limitations and either fail to solve the underlying pathophysiology or are highly invasive. To address these limitations, attention has focused on the use of biologics. The efficacy of these devices is attributed to presence of growth factors (GFs), cytokines (CKs), and extracellular vesicles (EVs). With this in mind, we formulated a novel cell-free stem cell-derived extract (CCM) from human progenitor endothelial stem cells (hPESCs). A preliminary study demonstrated the presence of essential components of regenerative medicine, namely GFs, CKs, and EVs, including exosomes, in CCM. The proposed study aims to evaluate the safety and efficacy of intraarticular injection of the novel cell-free stem cell-derived extract (CCM) for the treatment of knee OA. METHODS AND ANALYSIS: This is a non-randomized, open-label, multi-center, prospective study in which the safety and efficacy of intraarticular CCM in patients suffering from grade II/III knee OA will be evaluated. Up to 20 patients with grade II/III OA who meet the inclusion and exclusion criteria will be consented and screened to recruit 12 patients to receive treatment. The study will be conducted at up to 2 sites within the USA, and the 12 participants will be followed for 24 months. The study participants will be monitored for adverse reactions and assessed using Numeric Pain Rating Scale (NPRS), Patient-Reported Outcomes Measurement Information System (PROMIS) Score, Knee Injury and Osteoarthritis Outcome Score Jr. (KOOS Jr.), 36-ietm short form survey (SF-36), Single Assessment Numeric Evaluation (SANE), physical exams, plain radiography, and magnetic resonance imaging (MRI) with Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score for improvements in pain, function, satisfaction, and cartilage regeneration. DISCUSSION: This prospective study will provide valuable information into the safety and efficacy of intraarticular administration of cell-free stem cell-derived extract (CCM) in patients suffering with grade II/III knee OA. The outcomes from this initial study of novel CCM will lay the foundation for a larger randomized, placebo-controlled, multi-center clinical trial of intraarticular CCM for symptomatic knee OA. TRIAL REGISTRATION: Registered on July 21, 2021. ClinicalTrials.gov NCT04971798

Fixation Strategy Does Not Affect Risk of Growth Disturbance After Surgical Treatment of Pediatric Tibial Spine Fracture

PURPOSE: To characterize growth abnormalities after surgical treatment of tibial spine fractures and to investigate risk factors for these abnormalities. METHODS: A retrospective analysis of children who underwent treatment of tibial spine fractures between January 2000 and January 2019 was performed, drawing from a multicenter cohort among 10 tertiary care children\u27s hospitals. The entire cohort of surgically treated tibial spine fractures was analyzed for incidence and risk factors of growth disturbance. The cohort was stratified into those who were younger than the age of 13 years at the time of treatment in order to evaluate the risk of growth disturbance in those with substantial growth remaining. Patients with growth disturbance in this cohort were further analyzed based on age, sex, surgical repair technique, implant type, and preoperative radiographic measurements with χ RESULTS: Nine patients of 645 (1.4%) were found to have growth disturbance, all of whom were younger than 13 years old. Patients who developed growth disturbance were younger than those without (9.7 years vs 11.9 years, CONCLUSIONS: In this study, we found an overall low incidence of growth disturbance after surgical treatment of tibial spine fractures. There was no association with surgical technique and risk of growth disturbance. LEVEL OF EVIDENCE: Level III, retrospective comparative study

Is Nonoperative Treatment Appropriate for All Patients With Type 1 Tibial Spine Fractures? A Multicenter Study of the Tibial Spine Research Interest Group

BACKGROUND: Type 1 tibial spine fractures are nondisplaced or ≤2 mm-displaced fractures of the tibial eminence and anterior cruciate ligament (ACL) insertion that are traditionally managed nonoperatively with immobilization. HYPOTHESIS: Type 1 fractures do not carry a significant risk of associated injuries and therefore do not require advanced imaging or additional interventions aside from immobilization. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: We reviewed 52 patients who were classified by their treating institution with type 1 tibial spine fractures. Patients aged ≤18 years with pretreatment plain radiographs and ≤ 1 year of follow-up were included. Pretreatment imaging was reviewed by 4 authors to assess classification agreement among the treating institutions. Patients were categorized into 2 groups to ensure that outcomes represented classic type 1 fracture patterns. Any patient with universal agreement among the 4 authors that the fracture did not appear consistent with a type 1 classification were assigned to the type 1+ (T1+) group; all other patients were assigned to the true type 1 (TT1) group. We evaluated the rates of pretreatment imaging, concomitant injuries, and need for operative interventions as well as treatment outcomes overall and for each group independently. RESULTS: A total of 48 patients met inclusion criteria; 40 were in the TT1 group, while 8 were in the T1+ group, indicating less than universal agreement in the classification of these fractures. Overall, 12 (25%) underwent surgical treatment, and 12 (25%) had concomitant injuries. Also, 8 patients required additional surgical management including ACL reconstruction (n = 4), lateral meniscal repair (n = 2), lateral meniscectomy (n = 1), freeing an incarcerated medial meniscus (n = 1), and medial meniscectomy (n = 1). CONCLUSION: The classification of type 1 fractures can be challenging. Contrary to prior thought, a substantial number of patients with these fractures (\u3e20%) were found to have concomitant injuries. Overall, surgical management was performed in 25% of patients in our cohort

Anterior Displacement of Tibial Spine Fractures: Does Anatomic Reduction Matter?

BACKGROUND: Operative treatment of displaced tibial spine fractures consists of fixation and reduction of the fragment in addition to restoring tension of the anterior cruciate ligament. PURPOSE: To determine whether residual displacement of the anterior portion of a tibial spine fragment affects the range of motion (ROM) or laxity in operatively and nonoperatively treated patients. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: Data were gathered from 328 patients younger than 18 years who were treated for tibial spine fractures between 2000 and 2019 at 10 institutions. ROM and anterior lip displacement (ALD) measurements were summarized and compared from pretreatment to final follow-up. ALD measurements were categorized as excellent (0 to \u3c1 \u3emm), good (1 to \u3c3 \u3emm), fair (3 to 5 mm), or poor (\u3e5 mm). Posttreatment residual laxity and arthrofibrosis were assessed. RESULTS: Overall, 88% of patients (290/328) underwent operative treatment. The median follow-up was 8.1 months (range, 3-152 months) for the operative group and 6.7 months (range, 3-72 months) for the nonoperative group. The median ALD measurement of the cohort was 6 mm pretreatment, decreasing to 0 mm after treatment ( CONCLUSION: Residual ALD was not associated with posttreatment subjective residual laxity, extension loss, or flexion loss. The results suggest that anatomic reduction of a tibial spine fracture may not be mandatory if knee stability and functional ROM are achieved

Evaluation of Tibial Slope on Radiographs in Pediatric Patients With Tibial Spine Fractures: An Age- and Sex-Matched Study

BACKGROUND: A recent study has reported that the radiographic measurement of posterior tibial slope (PTS) is larger in male pediatric patients with tibial spine fractures (TSF) than in controls. However, they found no difference in PTS between female patients and controls. PURPOSE: (1) To identify whether PTS is larger in female pediatric patients with TSF than in female controls and (2) to validate the relationship between PTS and pediatric TSF in male patients. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: After an a priori power analysis, 84 pediatric patients with TSF (50 female patients and 34 male patients) and 84 age- and sex-matched controls were enrolled in this study. Demographic information, including sex, age, and race, was recorded. Skeletal maturity was determined based on the stage of epiphyseal union on knee radiographs. PTS was defined as the angle between a line perpendicular to the longitudinal axis of the tibia and the posterior inclination of the medial tibial plateau on standard knee lateral radiographs. RESULTS: The mean age when the TSF occurred was 11.2 ± 2.7 years for female patients and 12.9 ± 2.5 years for male patients. There was no significant difference in skeletal maturity between female patients and female controls or between male patients and male controls. The mean PTS was not significantly different between female patients (8.8°± 2.8°) and female controls (8.3°± 3.1°) ( CONCLUSION: PTS was not found to be a risk factor for pediatric TSF in female or male patients in this study