Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

Herein, we demonstrate that several reactions can be telescoped into a single continuous process and/or be carried out as a continuous multi-component reaction (MCR), by twin screw extrusion (TSE), in the complete absence of solvent.</p

Organic synthesis by Twin Screw Extrusion (TSE): continuous, scalable and solvent-free

Several organic reactions have been achieved quantitatively without any added solvent, using solid or liquid reagents, on a continuous basis; products are typically obtained directly in analytically pure form, requiring no work-up.</p