2 research outputs found
Boron Cluster Modification with Antiviral, Anticancer, and Modulation of Purinergic Receptors' Activities Based on the Nucleoside Structure
Nucleoside analogs have been in clinical use for several decades and have become
cornerstones of treatment for patients with cancer or viral infections [1,2]. This is
complemented with nucleoside antibiotics, a large family of microbial natural products
and synthetic derivatives derived from nucleosides and nucleotides [3].
The approval of several new nucleoside drugs over the past decade demonstrates that
this class of compounds still possesses strong potential [1,2]. The potential of nucleosides
in chemotherapy is enhanced by development of new chemistries for nucleoside
modification, better understanding of molecular mechanisms of nucleoside drugs’
actions [4], and pro‐drug technology [5,6]. One of the new developments in the medicinal
chemistry of nucleosides is nucleoside derivatives comprising a boron component
[7]. The boron part can contain a single boron atom [8] or several boron atoms in the
form of a boron cluster (Figure 1.2.1) [9–11]