51 research outputs found
IS TREATMENT-RESISTANCE IN PSYCHIATRIC DISORDERS A TRAP FOR POLYPHARMACY?
Background: Nowadays, more and more mental health professionals manage patients who fail treatment for major psychiatric
disorders. There is not a consensus on how to deal with treatment-resistance patients, but usually psychiatrists result to
polypharmacy.
Method: In reviewing the evidence based clinical research we will try to answer some questions about treatment-resistant
psychiatric disorders. Treatment-resistant symptoms complicate the clinical course of all psychiatric disorders especially schizophrenia,
causing the patients not to reach the therapeutical goal and enter remission. In consequence, polypharmacy is used to try to
deal with the remaining symptoms, raising other issues.
Summary: We will try to deal with this problematic issue through clinical studies and major research done to try and answer the
question posed
CORRELATION OF PRE-MORBID ALCOHOLISM AND CHANGES IN THE LEVEL OF BIOGENIC AMINE METABOLITES IN CEREBROSPINAL FLUID OF ACCUTE BRAIN INFARCTION PATIENTS
Background: The disorder of biogenic amine metabolism (serotonin ā 5-HT and dopamine ā DA) is expected in the brain (neuron)
damage caused by acute ischemia. It is known that long-term abuse of ethyl-alcohol damages the quality of neurons diffusely in the
brain. Cerebrospinal fluid (CSF) and its biochemical content, 5-HT and DA, are reliable indicators of the vitality of neurons.
The main objective of this research was to demonstrate that the elevated content of metabolites 5-HT and DA in the CSF in
patients with acute brain infarction, who were pre-morbid alcohol-dependent patients, is additionally emphasized by diffusive
damage of neuron vitality caused by alcoholism.
Subjects and methods: Study sample consists of two groups - 50 alcohol-dependent patients with acute brain infarction under
the age of 65 (group A) and 50 patients with acute brain infarction who were not alcohol-dependent (group B). All subjects
underwent the same procedure - CSF was taken during admission to the hospital and history was obtained through anamnesis,
heteroanamnesis and clinical examinations.
Results: Metabolism of DA and metabolic turnover of DA (3, 4 dihydroxyphenylacetic acid + homovanilic acid; DOPAC +
HVA) was elevated in the liquor of both patient groups. The statistically significant difference between the groups was found in
metabolic turnover of 5-HT (p<0.05), and metabolic turnover of DA (p<0.001).
Conclusions: The metabolic neuron disbalance, i.e. their pathophysiological-biochemical dysfunction as a result of acute brain
infarction, is present in a higher degree in patients with pre-morbid long-term alcohol abuse
The Life and Work of Ksenija AtanasijeviÄ (1894-1981) - Psychology and Anthropology as the Inevitability and Necessity of Philosophy
Ksenija AtanasijeviÄ (1894-1981) was the first woman in Serbia to obtain a Ph. D. in philosophy. Going through numerous psychological metamorphoses in her lifetime and confronted with numerous challenges, Ksenija AtanasijeviÄ developed a specific philosophical-psychological system of consolation prominently featuring the concepts of happiness, bliss, moderation, courage and wisdom. Modifying the original teachings of Democritus and Epicurus, Ksenija AtanasijeviÄ developed a distinctive anthropology based on confrontation with but equally the overcoming of obstacles, both internal (spiritual) as well as external ones. The philosopheress developed a reflexive and indeed metaphysical defensive psychotherapeutical skill at the root of which was cleansing the soul, as well as dedication to the realm of fancy, fantasy and imagination. Ksenija AtanasijeviÄ also had precious literary talent which was best expressed in her analyses of the poetry and prose of great Serbian writers (PanduroviÄ, NjegoÅ”, NastasijeviÄ, etc.). It is quite certain that this, with Anica SaviÄ-Rebac, definitely greatest Serbian philosopheress, through personal suffering, creative solitude and shrouded desperation built an utterly authentic and harmonious system of philosophical comfort
FOR THOSE WHO FIGHT, FALL AND RAISE AGAIN - IMPACT OF COVID-19 PANDEMIC ON MENTAL HEALTH OF HEALTH CARE PROVIDERS
Background: During the COVID-19 pandemic health care providers found themselves under increased demands in the work
environment and in their professional and personal lives which created both physical and mental health challenges. Thus, we aim to
provide an integrative review that identifies and summarizes the research published regarding mental health functioning in health
care providers, in Serbia, since the beginning of the pandemic.
Subjects and methods: A search of the published literature was conducted using Medline and SCIndex databases, applying key
words āCOVID-19ā and āSerbiaā. The search was limited to papers published since the beginning of the COVID-19 pandemic until
January 2022. Two reviewers independently screened the retrieved papers. The study used pre-defined inclusion and exclusion
criteria.
Results: We identified eight papers on the subject of mental health functioning in health care providers. The studies were all
original research papers with predominantly cross-sectional study design, using online assessments. Sample size varied in number of
participants and profile of medical providers (physicians, nurses and medical technicians, community pharmacists). Dominantly,
focus of interests of researchers were exploration of levels of anxiety, depression, sleep disturbances, burnout, as well as behavioural
changes and environmental influences.
Conclusions: The studies related to mental health of medical professionals show the importance of recognizing the psychological
challenges posed by health crises caused by COVID-19. They raise awareness of recognizing differences and difficulties between
wide range of medical sectors, and appeal for necessity for accessible and professional psychological support. Further studies
should address the detailed exploration of the mental health of this specific population, as well as propose strategies needed to
balance the challenges posed by the pandemic
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