2 research outputs found
The interaction between dietary patterns and melanocortin-4 receptor polymorphisms in relation to obesity phenotypes
Introduction: Data shows that interactions between dietary factors and genetic variants can
modulate the association of polymorphisms such as the Melanocortin-4 receptor (MC4R) gene
with obesity. Considering the limited data available on this topic we aimed to investigate
interactions between dietary patterns (DPs) and MC4R polymorphisms in relation to obesity
phenotypes. Methods: This cohort study was performed in the framework of Tehran Lipid and
Glucose Study; for eligible participants in this study (n = 3850), the median follow-up was 4
years. DPs were determined using factor analysis. The genotypes of polymorphisms
(17782313rs and 12970134rs) were identified and their interaction with DPs were assessed in
relation to incidence of obesity phenotypes including central obesity, general obesity and
visceral adiposity dysfunction. Results: The mean age of participants (62.5% females) were
37.0 ± 13.7 years. Two main DPs (healthy and unhealthy) were extracted. C-allele carriers of
rs17782313 in higher quartiles of the healthy DP score had a significant decrease in the
incidence of general obesity, compared to those who had the TT genotype (HR = 0.61, 95% CI
= 0.42–0.89, P interaction = 0.01). For rs12970134 A-allele carriers, subjects in the second
compared to the first quartile of the healthy DP score, had a significant decrease in the
incidence of general obesity (HR = 0.68, 95% CI = 0.46–0.99). There were no significant
interaction between DPs and MC4R variants in relation to other obesity phenotypes.
Conclusion: Our results indicate that the healthy DP could interact with rs17782313 in relation
to incidence of general obesit
The interaction between dietary patterns and melanocortin-4 receptor polymorphisms in relation to obesity phenotypes
Introduction: Data shows that interactions between dietary factors and genetic variants can modulate the
association of polymorphisms such as the Melanocortin-4 receptor (MC4R) gene with obesity. Considering the limited data available on this topic we aimed to investigate interactions between dietary patterns
(DPs) and MC4R polymorphisms in relation to obesity phenotypes.
Methods: This cohort study was performed in the framework of Tehran Lipid and Glucose Study; for
eligible participants in this study (n = 3850), the median follow-up was 4 years. DPs were determined
using factor analysis. The genotypes of polymorphisms (17782313rs and 12970134rs) were identified
and their interaction with DPs were assessed in relation to incidence of obesity phenotypes including
central obesity, general obesity and visceral adiposity dysfunction.
Results: The mean age of participants (62.5% females) were 37.0 ± 13.7 years. Two main DPs (healthy
and unhealthy) were extracted. C-allele carriers of rs17782313 in higher quartiles of the healthy DP
score had a significant decrease in the incidence of general obesity, compared to those who had the TT
genotype (HR = 0.61, 95% CI = 0.42–0.89, P interaction = 0.01). For rs12970134 A-allele carriers, subjects
in the second compared to the first quartile of the healthy DP score, had a significant decrease in the
incidence of general obesity (HR = 0.68, 95% CI = 0.46–0.99). There were no significantinteraction between
DPs and MC4R variants in relation to other obesity phenotypes.
Conclusion: Our results indicate that the healthy DP could interact with rs17782313 in relation to incidence of general obesit