Monitoring Human Impact in Show Caves. A Study of Four Romanian Caves

(1) Background: Show caves are unique natural attractions and touristic traffic can trigger their degradation within a short time. There are no universal solutions to counter the effects of the touristic impact upon the cave environment and both protection protocols and management plans have to be established on a case-by-case basis. (2) Methods: The study includes four show caves from the Romanian Carpathians, where monitoring of the number of visitors, paralleled by the monitoring of the main physicochemical parameters of the air and water (CO2, temperature, humidity, drip rate, conductivity, and pH) was implemented. (3) Results and Conclusions: The results of the study have: established a set of basic principles to be enforced by the management of show caves and issued a set of preventive measures and instructions to be followed by the personnel and stakeholders of the caves

Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures

Nanoparticle (NP)-based solutions for oncotherapy promise an improved efficiency of the anticancer response, as well as higher comfort for the patient. The current advancements in cancer treatment based on nanotechnology exploit the ability of these systems to pass biological barriers to target the tumor cell, as well as tumor cell organelles. In particular, iron oxide NPs are being clinically employed in oncological management due to this ability. When designing an efficient anti-cancer therapy based on NPs, it is important to know and to modulate the phenomena which take place during the interaction of the NPs with the tumor cells, as well as the normal tissues. In this regard, our review is focused on highlighting different approaches to studying the internalization patterns of iron oxide NPs in simple and complex 2D and 3D in vitro cell models, as well as in living tissues, in order to investigate the functionality of an NP-based treatment

Late-Holocene landscape evolution and human presence in the northern Danube delta (Chilia distributary lobes)

International audienceThis paper documents the Late-Holocene environmental changes and human presence in the northern Danube delta using a multidisciplinary approach that combines geoscientific data with archaeological findings, historical texts, and maps. It follows the formation and progression of the Chilia distributary and the reconfiguration of socioeconomic activities. Sedimentary facies identified on five new cores by changes in texture properties, magnetic susceptibility, geochemistry, and macro- and microfauna composition together with the newly obtained chronology constrain the complex evolution of the Chilia branch as filling in a long-lasting bay and then of a giant lagoon (Thiagola) which covered most of the northern delta since the Old Danube lobe inception (ca. 7500 yrs BP) till modern Chilia development. It initiated during the Greek Antiquity (ca. 2500 yrs ar BP) at the delta apex, while in Roman times (ca. 1800 yrs BP) it pursued its slow flowing into the vast Thiagola Lagoon. The most dramatic transformations occurred in the last 800 years when the river passed east of the Chilia promontory, rapidly went through the present-day Matița-Merhei basin (several decades), and created its first open-sea outlet. Solid discharge increased in two distinct periods, once in the Middle Ages (ca. 750 yrs BP) and then in the Modern Period (ca. 150 yrs BP) due to human-induced land-use changes in the Danube watershed. The chronology of the cultural remains on the pre-deltaic Chilia promontory and the multiproxy analysis of a sediment core retrieved nearby downstream suggest the terrestrial connection of the island with the mainland in ancient times. The hitherto contended issue of the old Thiagola Lagoon and its location are redefined here, as are the original identifications of ancient and medieval toponyms and hydronyms, especially for Chilia-Licostomo, Byzantine, Genoese, Moldavian, Ottoman, and Russian trading point of great importance in the political and economic history of the Black Sea and neighboring regions