Phenolic compounds profiling in zero-tannin and tannin-containing lentil seeds

Non-Peer Reviewe

Visible Light Photocatalytic Degradation of Azo Dye and a Real Textile Wastewater Using Mn, Mo, La/TiO2/AC Nanocomposite

Mn, Mo, La/TiO2/activated carbon (AC) photocatalysts were synthesized by sol-gel method. The prepared samples were characterized by XRD, FT-IR, BET, DRS, and FESEM techniques. The findings revealed that the synthesized catalysts were anatase type and nano-sized particles. The catalysts exhibited high adsorption ability in the visible light region with a red shift in the adsorption edge. The formation of Mn, Mo, La/TiO2/ AC crystallites in the activated carbon was confirmed by FE-SEM. The effects of initial dye concentration, catalyst dosage, reaction time, and solution pH were investigated for removal of Reactive Red 198. According to the obtained results, the maximum removal efficiency of 91 % was obtained at initial dye concentration of 20 mg L–1, pH of 3, and catalyst concentration of 2 g L–1. Synthesized nano-photocatalyst showed reasonable photo degradation efficiency of 84 % for initial COD concentration of 4700 mg L–1 in treatment of a real textile wastewater sample. GC/MS analysis of raw and treated wastewater confirmed degradation and producing of simple intermediates during the photocatalytic process. This work is licensed under a Creative Commons Attribution 4.0 International License

The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

Neurolysin (NLN) is a zinc metallopeptidase whose mitochondrial function is unclear. We found that NLN was overexpressed in almost half of patients with acute myeloid leukemia (AML), and inhibition of NLN was selectively cytotoxic to AML cells and stem cells while sparing normal hematopoietic cells. Mechanistically, NLN interacted with the mitochondrial respiratory chain. Genetic and chemical inhibition of NLN impaired oxidative metabolism and disrupted the formation of respiratory chain supercomplexes (RCS). Furthermore, NLN interacted with the known RCS regulator, LETM1, and inhibition of NLN disrupted LETM1 complex formation. RCS were increased in patients with AML and positively correlated with NLN expression. These findings demonstrate that inhibiting RCS formation selectively targets AML cells and stem cells and highlights the therapeutic potential of pharmacologically targeting NLN in AML

Hydrogen peroxide and photocatalysis

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