52 research outputs found
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
106 Degree of immune infiltration in active surveillance prostate patients detected by quantitative DNA staining helps predict progression
Radiation Recall Reaction Induced by Adjuvant Trastuzumab (Herceptin)
Although concerns of radiation sensitization have been raised with concurrent
trastuzumab (Herceptin) administration, there has been no published case of radiation recall reaction associated with trastuzumab. This case describes a clinical presentation consistent with a radiation recall reaction following administration of adjuvant trastuzumab after neoadjuvant FEC-D chemotherapy and locoregional radiotherapy for HER2-positive, locally advanced breast cancer in a premenopausal woman. Although the mechanism and etiology of radiation recall dermatitis remain unclear, this case raises further hypotheses regarding a possible drug dose-dependence and possible predisposing risk factor for the development of radiation recall reactions
Current State of Brachytherapy Teaching in Canada: A National Survey of Radiation Oncologists, Residents and Fellows
68: Intermediate-Risk Prostate Cancer, Androgen Deprivation Therapy and the Risk of Death
Influence of segmental urethral dosimetry on urinary morbidity in prostate brachytherapy
180 Patterns of Prostate Cancer Recurrence After Brachytherapy Imaged with PSMA-Targeting 18F-DCFPyl PET/CT
Severe Toxicity Following Permanent Low-Dose-Rate Prostate Brachytherapy in Patients With Inflammatory Bowel Disease
A Dose Response Analysis of 2000 Consecutive Patients Treated with Low-Dose-Rate Prostate Brachytherapy
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