Transformation of animal utilization strategies from the late Neolithic to the Han Dynasty in the Hexi Corridor, northwest China: Zooarchaeological and stable isotopic evidence

The trajectory and influencing factors for changes to ancient human livelihoods in the Hexi Corridor of northwest China have been intensively discussed. The Hexi Corridor is a key crossroads for trans-Eurasian exchange in both the prehistoric and historical periods. Although most studies have focused on the reconstruction of human paleodiet and plant subsistence, the diachronic change of animal utilization strategies spanning the prehistoric and historical periods remains unclear, due to the absence of zooarchaeological and isotopic studies, especially in Han Dynasty (202 BCE–220 CE). Here we report new zooarchaeological, stable isotope, and radiocarbon dating data from the Heishuiguo Cemetery of the Han Dynasty in the Hexi Corridor, indicating that humans mainly used domestic chickens, pigs and sheep as funerary objects, with other buried livestock including cattle, horses and dogs. Stable carbon and nitrogen isotope data suggest humans might have fed chickens, pigs and dogs more C4 foods (likely millets or their byproducts) than herbivorous livestock in the Heishuiguo during the Han Dynasty. Compared to other prehistoric zooarchaeological and isotopic studies in the Hexi Corridor, we detected an increasing significance of herbivorous livestock in animal utilization strategies compared with omnivorous livestock, and a basic declining weight of C4 foods in fodders from ∼2,300 to 200 BCE, which was probably induced by long-distance exchange and climate fluctuation. However, the trend was reversed during the Han Dynasty in the Hexi Corridor, primarily due to the control of the area by the Han Empire and the subsequent massive immigration from the Yellow River valley of north China

Considerable effects of lateralization and aging in intracortical excitation and inhibition

IntroductionFindings based on the use of transcranial magnetic stimulation and electromyography (TMS-EMG) to determine the effects of motor lateralization and aging on intracortical excitation and inhibition in the primary motor cortex (M1) are inconsistent in the literature. TMS and electroencephalography (TMS-EEG) measures the excitability of excitatory and inhibitory circuits in the brain cortex without contamination from the spine and muscles. This study aimed to investigate the effects of motor lateralization (dominant and non-dominant hemispheres) and aging (young and older) and their interaction effects on intracortical excitation and inhibition within the M1 in healthy adults, measured using TMS-EMG and TMS-EEG.MethodsThis study included 21 young (mean age = 28.1 ± 3.2 years) and 21 older healthy adults (mean age = 62.8 ± 4.2 years). A battery of TMS-EMG measurements and single-pulse TMS-EEG were recorded for the bilateral M1.ResultsTwo-way repeated-measures analysis of variance was used to investigate lateralization and aging and the lateralization-by-aging interaction effect on neurophysiological outcomes. The non-dominant M1 presented a longer cortical silent period and larger amplitudes of P60, N100, and P180. Corticospinal excitability in older participants was significantly reduced, as supported by a larger resting motor threshold and lower motor-evoked potential amplitudes. N100 amplitudes were significantly reduced in older participants, and the N100 and P180 latencies were significantly later than those in young participants. There was no significant lateralization-by-aging interaction effect in any outcome.ConclusionLateralization and aging have independent and significant effects on intracortical excitation and inhibition in healthy adults. The functional decline of excitatory and inhibitory circuits in the M1 is associated with aging

Examining the generalizability of research findings from archival data

This initiative examined systematically the extent to which a large set of archival research findings generalizes across contexts. We repeated the key analyses for 29 original strategic management effects in the same context (direct reproduction) as well as in 52 novel time periods and geographies; 45% of the reproductions returned results matching the original reports together with 55% of tests in different spans of years and 40% of tests in novel geographies. Some original findings were associated with multiple new tests. Reproducibility was the best predictor of generalizability—for the findings that proved directly reproducible, 84% emerged in other available time periods and 57% emerged in other geographies. Overall, only limited empirical evidence emerged for context sensitivity. In a forecasting survey, independent scientists were able to anticipate which effects would find support in tests in new samples

Dietary shift and social hierarchy from the Proto-Shang to Zhou Dynasty in the Central Plains of China

The Proto-Shang, the Shang and the Zhou dynasties (∼2000–221 BCE: Before Common Era) are key periods in the origin and evolution of ancient civilizations in China since the periods include the processes and mechanisms of social development in the Central Plains of China during the Bronze Age. However, human-environment interactions in the context of trans-Eurasia cultural exchange during that time are not well-understood. In this study, isotopic analysis and radiocarbon dating of human and animal bones from Xinancheng cemetery in southeast Shanxi Province are reported. It was deduced that, for the period ∼1000–800 BCE, humans buried in Xinancheng cemetery relied primarily on C _4 -based foods and upper-status individuals consumed more animal protein and probably C _3 crops. Also, considering the paleoclimate and other archaeological data of the Central Plains, the human diet and subsistence strategies changed significantly with more C _3 staples such as wheat being consumed during the Eastern Zhou (770–221 BCE), as evidenced by an increased intake of wheat by lower-status individuals and the development of a mixed wheat and millet agricultural system. It is argued that the socio-economic change around the late western Zhou-early eastern Zhou Dynasty occurred as a result of the necessity to adapt to the aggravation caused by climate deterioration and population pressures, factors which profoundly influenced the economic and lifestyle patterns in ancient China. The socio-economic system of the Eastern Zhou Dynasty displayed more resilience to climate change than that of earlier periods

iRoot SP Promotes Osteo/Odontogenesis of Bone Marrow Mesenchymal Stem Cells via Activation of NF-κB and MAPK Signaling Pathways

The regeneration of bone and tooth tissues, and related cellular therapies, has attracted widespread attention. Bone marrow mesenchymal stem cells (BMSCs) are potential candidates for such regeneration. iRoot SP is a premixed bioceramic root canal sealer widely used in clinical settings. However, the effect of iRoot SP on the biological features of BMSCs has not been elucidated. In the present study, we found that 0.2 mg/ml iRoot SP conditioned medium promoted osteo/odontogenic differentiation and enhanced mineralization of BMSCs without affecting the proliferative ability. Mechanistically, the NF-κB and MAPK signaling pathways were activated in SP-treated BMSCs, and differentiation was inhibited when cultured with the specific inhibitor. Taken together, these findings demonstrate that iRoot SP promotes osteo/odontogenic differentiation of BMSCs via the NF-κB and MAPK signaling pathways, which could provide a new theoretical basis for clinical applications of iRoot SP and a new therapeutic target for the regeneration of bone and tooth tissue in the future

Effect of Drought on Agronomic Traits of Rice and Wheat: A Meta-Analysis

Drought has been one of the most important limiting factors for crop production, which deleteriously affects food security worldwide. The main objective of the present study was to quantitatively assess the effect of drought on the agronomic traits (e.g., plant height, biomass, yield, and yield components) of rice and wheat in combination with several moderators (e.g., drought stress intensity, rooting environment, and growth stage) using a meta-analysis study. The database was created from 55 published studies on rice and 60 published studies on wheat. The results demonstrated that drought decreased the agronomic traits differently between rice and wheat among varying growth stages. Wheat and rice yields decreased by 27.5% and 25.4%, respectively. Wheat grown in pots showed greater decreases in agronomic traits than those grown in the field. Rice showed opposite growing patterns when compared to wheat in rooting environments. The effect of drought on rice increased with plant growth and drought had larger detrimental influences during the reproductive phase (e.g., blooming stage, filling stage, and maturity). However, an exception was found in wheat, which had similar decreased performance during the complete growth cycle. Based on these results, future droughts could produce lower yields of rice and wheat when compared to the current drought

Short report: depression and anxiety symptoms as predictors of adverse cardiovascular events in Chinese patients after percutaneous coronary intervention

Depression and anxiety often co-occur in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI). This study was conducted to examine the predictive value of depression, anxiety, and their combination on the prognosis of Chinese PCI patients. A multicenter prospective study was undertaken with a sample of 309 primary PCI patients. The Hospital Anxiety and Depression Scale (HADS) was completed at baseline to assess anxiety and depression symptoms. Major adverse cardiovascular events (MACEs) were recorded for 12 months after PCI . Days from baseline to the first MACE was the outcome variable. MACEs occurred in 26 (8.4%) patients. After adjustments for socio-demographic and clinical characteristics, a Cox proportional hazards regression model revealed that depression (HR = 2.70, 95% confidence interval [CI] 1.22–5.95; p =.014) and anxiety (HR = 2.56, 95% CI 1.18–5.54; p =.017) symptoms were independent predictors of MACEs. A sub-analysis showed that the cumulative event-free survival curves did not differ among depressed and anxious patients and depressed but non-anxious patients (Log Rank p =.52). In conclusion, depression is associated with an increased risk for MACEs post-PCI, independent of anxiety. Although anxiety is associated with MACEs, it has no additional predictive value when co-occurring with depression

Limited ability of increased sequencing depth in detecting cases missed by noninvasive prenatal testing: a comparative analysis of 3 clinical cases

Abstract Increased sequencing depth can improve the detection rate of noninvasive prenatal testing (NIPT) for chromosome aneuploidies and copy number variations (CNVs). However, due to the technical limitations of NIPT, false-positives and false-negatives are inevitable. False-positives for aneuploidy and CNVs have been widely reported, but few missed cases have been reported. In this study, we report 3 patients missed by NIPT, which were still missed after increasing the sequencing depth. To verify the detection efficiency of the platform, the results of NIPT in 32,796 patients treated in Yulin Women and Children Health Care Hospital from 2020 to 2022 were retrospectively analyzed. Data on false-negative cases found by postnatal follow-up or amniocentesis were collected, and the sequencing data, pregnancy examination data, and postnatal follow-up results of these missed patients were summarized. Five patients missed by NIPT were found, and they were missed again by retesting or increasing the sequencing depth. Except for hypospadias found in 1 patient, ultrasonography of the other 4 patients showed no obvious abnormalities during the whole pregnancy. Our results suggest that pregnant women should be fully informed of the benefits and limitations of NIPT before undergoing the examination to avoid unnecessary medical disputes

Efficient computation of motif discovery on Intel Many Integrated Core (MIC) Architecture

Abstract Background Novel sequence motifs detection is becoming increasingly essential in computational biology. However, the high computational cost greatly constrains the efficiency of most motif discovery algorithms. Results In this paper, we accelerate MEME algorithm targeted on Intel Many Integrated Core (MIC) Architecture and present a parallel implementation of MEME called MIC-MEME base on hybrid CPU/MIC computing framework. Our method focuses on parallelizing the starting point searching method and improving iteration updating strategy of the algorithm. MIC-MEME has achieved significant speedups of 26.6 for ZOOPS model and 30.2 for OOPS model on average for the overall runtime when benchmarked on the experimental platform with two Xeon Phi 3120 coprocessors. Conclusions Furthermore, MIC-MEME has been compared with state-of-arts methods and it shows good scalability with respect to dataset size and the number of MICs. Source code: https://github.com/hkwkevin28/MIC-MEME

Diurnal Variations of Isoprene, Monoterpenes, and Toluene Oxidation Products in Aerosols at a Rural Site of Guanzhong Plain, Northwest China

In this study, the characteristics and formation mechanism of summertime isoprene, monoterpene, and toluene-derived secondary organic aerosols (SOAs) were investigated in a rural area of Guanzhong Plain, Northwest China. The variations in key indicators of primary sources indicated a significant influence of biomass burning on PM2.5 during the observation period. The concentrations of total measured SOA tracers from isoprene, monoterpene, and toluene were 40.85 +/- 17.31, 24.27 +/- 7.50, and 10.61 +/- 0.33 ng/m(3), respectively. The average ratio of cis-pinonic and pinic acids to 3-Methyl-1,2,3-butanetricarboxylic acid (MBTCA)(P/M) were 0.45 and 0.85 by day and by night, respectively. The low ratio in the daytime was mainly due to the stronger photo-degradation and particle-to-gas distribution of semi-volatile cis-pinonic and pinic acids. The monoterpene SOA tracers were significantly correlated with levoglucosan at night (R-2 = 0.51, p 0.67, p < 0.01), indicating the significant contribution of biomass combustion to these SOAs. The mass concentration of isoprene-, monoterpenes-, and toluene-derived SOC was estimated by using the tracer yield method. The total calculated SOCs by day and by night were 0.25-0.71 (average: 0.46) and 0.26-0.78 (average: 0.42) mu gC/m(3), accounting for 3.35-10.58% and 3.87-13.51% of OC by day and by night, respectively