4 research outputs found
A preliminary multivariable analysis of factors associated with feto-maternal partitioning of persistent organic pollutants
To investigate trans-placental transport (TPT) of persistent organic pollutants (POPs) and its associated factors, a preliminary multiple linear regression (MLR) analysis was employed. The dependent variable of MLR model was the feto-maternal ratio (FM-ratio) of PCBs, PCDD/Fs, and PBDEs, and the independent variables included selected physicochemical properties of POPs and physiological characteristics of the participants, which were obtained from POP levels 20 congeners from 20 pairs of mother and fetus. The adjusted R2 of the model was 0.510, and the lipid content in the maternal and cord sera, gestational age and birth weight of the fetus, and molecular size and lipophilicity of the POPs were significantly associated with FM-ratio
An advanced 3D lymphatic system for assaying human cutaneous lymphangiogenesis in a microfluidic platform
Abstract The human cutaneous lymphatic system strictly controls lymphatic functions by coordinating with skin cells. The lymphatic system plays important roles in removing cell waste, residual proteins, various antigens, and immune cells from tissues to maintain homeostasis and activate the immune system through the drainage of interstitial fluid1,2. The skin protects our body from external stimuli such as pathogens through the cutaneous lymphatic system3,4. Herein, to develop an in vitro human cutaneous lymphatic model, we present two 3D microfluidic platforms: a lymphangiogenesis model with a precollecting lymphatic vessel-like structure and an advanced lymphangiogenesis model with a functional cutaneous barrier and a precollecting lymphatic vessel-like structure. In addition, we rapidly analyzed prolymphangiogenic effects using methods that incorporate a high-speed image processing system and a deep learning-based vascular network analysis algorithm by 12 indices. Using these platforms, we evaluated the pro-lymphangiogenic effect of Lymphanax, a natural product derived from fresh ginseng. As a result, we demonstrated that Lymphanax induces robust lymphangiogenesis without any structural abnormalities. In conclusion, we suggest that these innovative platforms are useful for studying the interaction between the skin and lymphatic system as well as evaluating the prolymphangiogenic effects of drugs and cosmetics