Enhancing the Legal and Regulatory Environment for Investment in Social Enterprise

The objectives of this Note are: 1) to provide readers interested in social enterprise and entrepreneurship an introduction to these endeavors and the growing trend toward using them; 2) to present the challenges stemming from the legal and financial frameworks surrounding social investment activity, which can inhibit the survival and growth of social enterprises; and 3) to propose suggestions for addressing such challenges and limitations in order to better support the survival of social enterprise. Part II and Part III provide a broad perspective of the types of investment in and nurturing of social entrepreneurship in the U.S. Part IV analyzes the current business and regulatory framework supporting entrepreneurial ventures and provides suggestions to improve their potential to facilitate sustainable growth of social entrepreneurship

Enhancing the Legal and Regulatory Environment for Investment in Social Enterprise

The objectives of this Note are: 1) to provide readers interested in social enterprise and entrepreneurship an introduction to these endeavors and the growing trend toward using them; 2) to present the challenges stemming from the legal and financial frameworks surrounding social investment activity, which can inhibit the survival and growth of social enterprises; and 3) to propose suggestions for addressing such challenges and limitations in order to better support the survival of social enterprise. Part II and Part III provide a broad perspective of the types of investment in and nurturing of social entrepreneurship in the U.S. Part IV analyzes the current business and regulatory framework supporting entrepreneurial ventures and provides suggestions to improve their potential to facilitate sustainable growth of social entrepreneurship

The influence of different row spacing and weed control intervals on weed infestation and yield-related traits of American (Gossypium hirsutum L.) and Desi (Gossypium arboreum) cotton

Narrow row spacing has attracted significant attention due to its beneficial impacts on weed management in cotton. This study compared the effects of normal and ultra-narrow row spacing on critical periods of weed control in American (Gossypium hirsutum L.) and ‘Desi’ (Gossypium arboreum) cotton. Two different row spacings (i.e., recommended (75 cm) and ultra-narrow (30 cm)) and three weed control intervals (i.e., weed control at 30, 60 and 90 days after sowing (DAS)) were included in the study. Weedy-check and weed-free treatments were included in the experiment as controls for comparison. ‘Desi’ cotton grown under ultra-narrow spacing recorded the lowest weed density and individual density of Trianthema portulacastarum L., Cyperus rotundus L., Cynodon dactylon L., Echinochloa colona (L.) Link and Digera muricata (L.) Mart. Moreover, ‘Desi’ cotton sown under ultra-narrow spacing with weed-free and weed control at 30 DAS resulted in the highest leaf area index (LAI), leaf area duration (LAD), net assimilation late (NAR), root elongation rate (RER) and root growth rate (RGR) at all sampling dates. Likewise, ‘desi’ cotton sown under recommended row spacing and weed-free conditions produced the highest number of sympodial and monopodial branches, number of flowers and bolls per plant, whereas the highest seed cotton yield of ‘Desi’ cotton was noted under ultra-narrow spacing and weed-free conditions. It is concluded that sowing both cotton types in ultra-narrow row spacing and controlling weeds at 30 DAS will result in lower weed infestation and higher seed cotton yield

Giant tonsillolith causing odynophagia in a child: a rare case report

Giant tonsillolith is a rare clinical entity. Commonly, it occurs between 20–77 years of age. We had a twelve years old female patient, who had odynophagia due to a giant tonsillolith. The stone was removed and tonsillectomy was performed. We reviewed the literature on this rare clinical entity and found that this is the fourth case of giant tonsillolith in a child and largest ever tonsillolith to be reported in English literature

Shockwaves and the Rolling Stones: An Overview of Pediatric Stone Disease

Urinary stone disease is a common problem in adults, with an estimated 10% to 20% lifetime risk of developing a stone and an annual incidence of almost 1%. In contrast, in children, even though the incidence appears to be increasing, urinary tract stones are a rare problem, with an estimated incidence of approximately 5 to 36 per 100,000 children. Consequently, typical complications of rare diseases, such as delayed diagnosis, lack of awareness, and specialist knowledge, as well as difficulties accessing specific treatments also affect children with stone disease. Indeed, because stone disease is such a common problem in adults, frequently, it is adult practitioners who will first be asked to manage affected children. Yet, there are unique aspects to pediatric urolithiasis such that treatment practices common in adults cannot necessarily be transferred to children. Here, we review the epidemiology, etiology, presentation, investigation, and management of pediatric stone disease; we highlight those aspects that separate its management from that in adults and make a case for a specialized, multidisciplinary approach to pediatric stone disease

Adapting an evidence-based intervention for autism spectrum disorder for scaling up in resource-constrained settings: the development of the PASS intervention in South Asia.

Evidence-based interventions for autism spectrum disorders evaluated in high-income countries typically require highly specialised manpower, which is a scarce resource in most low- and middle-income settings. This resource limitation results in most children not having access to evidence-based interventions. This paper reports on the systematic adaptation of an evidence-based intervention, the Preschool Autism Communication Therapy (PACT) evaluated in a large trial in the United Kingdom for delivery in a low-resource setting through the process of task-shifting. The adaptation process used the Medical Research Council framework for the development and adaptation of complex interventions, focusing on qualitative methods and case series and was conducted simultaneously in India and Pakistan. The original intervention delivered by speech and language therapists in a high-resource setting required adaptation in some aspects of its content and delivery to enhance contextual acceptability and to enable the intervention to be delivered by non-specialists. The resulting intervention, the Parent-mediated intervention for Autism Spectrum Disorder in South Asia (PASS), shares the core theoretical foundations of the original PACT but is adapted in several respects to enhance its acceptability, feasibility, and scalability in low-resource settings

A review on the assessment of stress conditions for simultaneous production of microalgal lipids and carotenoids

Microalgal species are potential resource of both biofuels and high-value metabolites, and their production is growth dependent. Growth parameters can be screened for the selection of novel microalgal species that produce molecules of interest. In this context our review confirms that, autotrophic and heterotrophic organisms have demonstrated a dual potential, namely the ability to produce lipids as well as value-added products (particularly carotenoids) under influence of various physico-chemical stresses on microalgae. Some species of microalgae can synthesize, besides some pigments, very-long-chain polyunsaturated fatty acids (VL-PUFA,>20C) such as docosahexaenoic acid and eicosapentaenoic acid, those have significant applications in food and health. Producing value-added by-products in addition to biofuels, fatty acid methyl esters (FAME), and lipids has the potential to improve microalgae-based biorefineries by employing either the autotrophic or the heterotrophic mode, which could be an offshoot of biotechnology. The review considers the potential of microalgae to produce a range of products and indicates future directions for developing suitable criteria for choosing novel isolates through bioprospecting large gene pool of microalga obtained from various habitats and climatic conditions

Diagnostic yield and safety of ultrasound-guided bowel mass biopsies in children

Background Traditionally, ultrasound (US)-guided bowel mass biopsies are avoided in favour of endoscopic or surgical biopsies. However, endoscopy cannot easily reach lesions between the duodenojejunal flexure and the terminal ileum and lesions not involving the mucosa may not be accessible via an endoscopic route. Objective The aim of this study was to report our technique and to assess the diagnostic accuracy and safety of US-guided biopsy of bowel masses in children. Materials and methods We conducted a 14-year retrospective review of US-guided bowel mass biopsies at a single paediatric hospital. Results Twenty US-guided bowel mass biopsies were performed in 19 patients (median age: 6 years and 6 months, range: 22 months– 17 years, median weight: 22 kg, range: 10.2–48.4 kg). For 14 biopsies, there was no other lesion that could potentially be biopsied. A percutaneous coaxial technique was used for 19 biopsies and a transanal non-coaxial biopsy was performed in 1. A median of 9 (range: 2–15) cores of tissue was obtained at each biopsy. The technical success rate and adequacy of diagnostic yield were 100%. The most common diagnosis was lymphoma, which occurred in 16 biopsies. Three biopsies contained mucosa. There was one complication out of 20 biopsies (5%, 95% confidence interval 0–15%): a self-limiting, post biopsy pyrexia. Nineteen procedures were accompanied by a bone marrow aspirate and/or trephine within 2 weeks of the bowel biopsy, only one of which was diagnostic. Conclusion US-guided bowel mass biopsy can be performed safely in children, with a high diagnostic yield and low complication rat