Characterisation and Skin Distribution of Lecithin-Based Coenzyme Q10-Loaded Lipid Nanocapsules

The purpose of this study was to investigate the influence of the inner lipid ratio on the physicochemical properties and skin targeting of surfactant-free lecithin-based coenzyme Q10-loaded lipid nanocapsules (CoQ10-LNCs). The smaller particle size of CoQ10-LNCs was achieved by high pressure and a lower ratio of CoQ10/GTCC (Caprylic/capric triglyceride); however, the zeta potential of CoQ10-LNCs was above /− 60 mV/ with no distinct difference among them at different ratios of CoQ10/GTCC. Both the crystallisation point and the index decreased with the decreasing ratio of CoQ10/GTCC and smaller particle size; interestingly, the supercooled state of CoQ10-LNCs was observed at particle size below about 200 nm, as verified by differential scanning calorimetry (DSC) in one heating–cooling cycle. The lecithin monolayer sphere structure of CoQ10-LNCs was investigated by cryogenic transmission electron microscopy (Cryo-TEM). The skin penetration results revealed that the distribution of Nile red-loaded CoQ10-LNCs depended on the ratio of inner CoQ10/GTCC; moreover, epidermal targeting and superficial dermal targeting were achieved by the CoQ10-LNCs application. The highest fluorescence response was observed at a ratio of inner CoQ10/GTCC of 1:1. These observations suggest that lecithin-based LNCs could be used as a promising topical delivery vehicle for lipophilic compounds

Operation Twins: Synchronized Production-Intralogistics for Industry 4.0 Manufacturing

Part 12: Regular Session: AI-Based Approaches for Quality and Performance Improvement of Production SystemsInternational audienceThe widespread adoption of Industry 4.0 technologies in factories are transforming manufacturing operations management. Multiple resources are interconnected, massive data are real-timely collected by smart devices to provide visibility and traceability. It is generally acknowledged that real-time data are beneficial for manufacturing operations management. How to utilize these data for facilitating production and intralogistics (PiL) operations management is an emerging challenge. This study proposes a new concept, operation twins, for achieving synchronized PiL operations based on three dimensions of synchronization (cyber-physical synchronization, spatial-temporal synchronization, and data-driven decisions synchronization)