Comparative efficacy of different exercise methods to improve cardiopulmonary function in stroke patients: a network meta-analysis of randomized controlled trials

BackgroundAlthough some studies have shown that exercise has a good effect on improving the cardiopulmonary function of stroke patients, it still needs to be determined which exercise method does this more effectively. We, therefore, aimed to evaluate the effectiveness of different exercise methods in improving cardiovascular function in stroke patients through a network meta-analysis (NMA), providing a basis to select the best treatment plan for stroke patients.MethodsWe systematically searched CNKI, WanFang, VIP, CBM, PubMed, Embase, Web of Science, and The Cochrane Library databases from establishment to 30 April 2023. Randomized controlled trials (RCTS) on exercise improving cardiopulmonary function in stroke patients were included, and we screened the included articles and extracted the relevant data. RevMan (version 5.4) and Stata (version 17.0) were used for data analysis.ResultsWe included 35 RCTs and a total of 2,008 subjects. Intervention measures included high-intensity interval training (HIIT), aerobic training (AT), resistance training (RT), combined aerobic and resistance exercise (CE), and conventional therapy (CT). In the network meta-analysis, the surface under the cumulative ranking area (SUCRA) ranking result indicated that HIIT improved peak oxygen uptake (VO2peak) and 6 mins walking distance (6MWD) optimally, with rankings of HIIT (100.0%) > CE (70.5%) > AT (50.2%) > RT (27.7%) > CT (1.6%), and HIIT (90.9%) > RT (60.6%) > AT (48.9%) > RT (48.1%) > CT (1.5%), respectively. The SUCRA ranking result showed that CE improved systolic blood pressure (SBP) and diastolic blood pressure (DBP) optimally, with rankings of CE (82.1%) > HIIT (49.8%) > AT (35.3%) > CT (32.8%), and CE (86.7%) > AT (45.0%) > HIIT (39.5%) > CT (28.8%), respectively.ConclusionWe showed that exercise can effectively improve the cardiopulmonary function of stroke patients. HIIT was the most effective in improving VO2peak and 6MWD in stroke patients. CE was the most effective in improving SBP and DBP in stroke patients. However, due to the limitations of existing clinical studies and evidence, larger sample size, multi-center, and high-quality RCTs are needed to verify the above conclusions in the future.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier [CRD42023436773]

Monolayer hydrophilic MoS2 with strong charge trapping for atomically thin neuromorphic vision systems

Effective control of electrical and optoelectronic properties of two-dimensional layered materials, one of the key requirements for applications in advanced optoelectronics with multiple functions, has been hindered by the difficulty of elemental doping, which is commonly utilized in Si technology. In this study, we proposed a new method to synthesize hydrophilic MoS2 monolayers through covalently introducing hydroxyl groups during their growth process. These hydroxyl groups exhibit a strong capability of charge trapping, and thus the hydrophilic MoS2 monolayers achieve excellent electrical, optical, and memory properties. Optical memory transistors, made from a single component of monolayer hydrophilic MoS2, exhibit not only excellent light-dependent and time-dependent photoelectric performance, but also good photo-responsive memory characteristics with over multi-bit storage and more than 104 switching ratios. Atomically thin neuromorphic vision systems (with a concept of proof of 10 × 10 neuromorphic visual image) are manufactured from arrays of hydrophilic MoS2 optical memory transistors, showing high quality image sensing and memory functions with a high color resolution. These results proved our new concepts to realize image memorization and simplify the pixel matrix preparation process, which is a significant step toward the development of future artificial visual systems

Ultrafast and Sensitive Self-Powered Photodetector Featuring Self-Limited Depletion Region and Fully Depleted Channel with van der Waals Contacts

Self-powered photodetectors with great potential for implanted medical diagnosis and smart communications have been severely hindered by the difficulty of simultaneously achieving high sensitivity and fast response speed. Here, we report an ultrafast and highly sensitive self-powered photodetector based on two-dimensional (2D) InSe, which is achieved by applying a device architecture design and generating ideal Schottky or ohmic contacts on 2D layered semiconductors, which are difficult to realize in the conventional semiconductors owing to their surface Fermi-level pinning. The as-fabricated InSe photodiode features a maximal lateral self-limited depletion region and a vertical fully depleted channel. It exhibits a high detectivity of 1.26 × 1013 Jones and an ultrafast response speed of ∼200 ns, which breaks the response speed limit of reported self-powered photodetectors based on 2D semiconductors. The high sensitivity is achieved by an ultralow dark current noise generated from the robust van der Waals (vdW) Schottky junction and a high photoresponsivity due to the formation of a maximal lateral self-limited depletion region. The ultrafast response time is dominated by the fast carrier drift driven by a strong built-in electric field in the vertical fully depleted channel. This device architecture can help us to design high-performance photodetectors utilizing vdW layered semiconductors

Property parameter determination in individual layers for separately fractured wells with commingled production in multi-layered reservoirs

Abstract At present, without any separate rate test for each layer, there is no way to determinate the properties of individual layers for separately fractured wells with commingled production in multi-layered reservoirs. In order to address this issue, much research work was performed and elucidated in this article. To begin with, we illustrated a basic physical model for a separately fractured well in a multi-layered reservoir. Next, we stated the common determination method that can only be used to gain the average properties of multi-layered reservoirs. Then, according to the physical model, we newly established a mathematical model and plotted standard well-test type curves; additionally, we also discussed why we cannot determinate the properties of individual layers by using the new well-test model. What’s more, we presented a new method to determinate the properties of individual layers. Moreover, we compared the advantages and disadvantages among the three methods. In addition, by using the new determination method, we particularly took two field wells as examples to demonstrate how to determine the properties of individual layers. The proposed new method was validated by use of the common method, the new well-test model and the microseismic monitoring results. At the end, we summarized the research conclusions and indicated that the new method was a good tool to determinate the properties of individual layers in multi-layered reservoirs

Two-Dimensional van der Waals Materials with Aligned In-Plane Polarization and Large Piezoelectric Effect for Self-Powered Piezoelectric Sensors

Piezoelectric two-dimensional (2D) van der Waals (vdWs) materials are highly desirable for applications in miniaturized and flexible/wearable devices. However, the reverse-polarization between adjacent layers in current 2D layered materials results in decreasing their in-plane piezoelectric coefficients with layer number, which limits their practical applications. Here, we report a class of 2D layered materials with an identical orientation of in-plane polarization. Their piezoelectric coefficients (e22) increase with layer number, thereby allowing for the fabrication of flexible piezotronic devices with large piezoelectric responsivity and excellent mechanical durability. The piezoelectric outputs can reach up to 0.363 V for a 7-layer α-In2Se3 device, with a current responsivity of 598.1 pA for 1% strain, which is 1 order of magnitude higher than the values of the reported 2D piezoelectrics. The self-powered piezoelectric sensors made of these newly developed 2D layered materials have been successfully used for real-time health monitoring, proving their suitability for the fabrication of flexible piezotronic devices due to their large piezoelectric responses and excellent mechanical durability

Ultralow Power Optical Synapses Based on MoS2 Layers by Indium-Induced Surface Charge Doping for Biomimetic Eyes

Biomimetic eyes, with their excellent imaging functions such as large fields of view and low aberrations, have shown great potentials in the fields of visual prostheses and robotics. However, high power consumption and difficulties in device integration severely restrict their rapid development. In this study, an artificial synaptic device consisting of a molybdenum disulfide (MoS2) film coated with an electron injection enhanced indium (In) layer is proposed to increase the channel conductivity and reduce the power consumption. This artificial synaptic device achieves an ultralow power consumption of 68.9 aJ per spike, which is several hundred times lower than those of the optical artificial synapses reported in literature. Furthermore, the multilayer and polycrystalline MoS2 film shows persistent photoconductivity performance, effectively resulting in short-term plasticity, long-term plasticity, and their transitions between each other. A 5 × 5 In/MoS2 synaptic device array is constructed into a hemispherical electronic retina, demonstrating its impressive image sensing and learning functions. This research provides a new methodology for effective control of artificial synaptic devices, which have great opportunities used in bionic retinas, robots, and visual prostheses

Kirigami-inspired highly stretchable nanoscale devices using multi-dimensional deformation of monolayer MoS2

Two-dimensional (2D) layered materials, such as MoS2, are greatly attractive for flexible devices due to their unique layered structures, novel physical and electronic properties, and high mechanical strength. However, their limited mechanical strains (<2%) can hardly meet the demands of loading conditions for most flexible and stretchable device applications. In this paper, inspired from Kirigami, ancient Japanese art of paper cutting, we design and fabricate nanoscale Kirigami architectures of 2D layered MoS2 on a soft substrate of PDMS using a top-down fabrication process. Results show that the Kirigami structures significantly improve the reversible strechability of flexible 2D MoS2 electronic devices, which is increased from 0.75% to ~15%. This increase in flexibility is originated from a combination of multi-dimensional deformation capabilities from the nanoscale Kirigami architectures consisting of in-plane stretching and out-of-plane deformation. We further discover a new fundamental relationship of electrical conductance and large strain in MoS2 Kirigami structures through both experimental work and finite element simulation. Results show that the electrical conductance of the stretchable MoS2 Kirigami is closely related to its different stages of structural evolutions under strain: e.g., elastic stretching; then a combination of elastic stretching and out-of-plane buckling; and finally stretching and structural damage. This method provides a new opportunity to fabricate highly flexible and stretchable sensors and actuators using different types of 2D materials

Phase Transitions and Hygroscopic Growth of Mg(CIO4)(2), NaCIO4, and NaCIO4 center dot H2O: Implications for the Stability of Aqueous Water in Hyperarid Environments on Mars and on Earth

In general pure liquid water is not thermodynamically stable on Mars due to the extremely cold and dry environment. The presence in the soil of perchlorates, which could lower the freezing point of water and form aqueous solutions by taking up water vapor even under subsaturated conditions, has been proposed to explain the possible existence of liquid water on Mars and in some hyperarid environments on Earth. In this work, the phase transitions and hygroscopic growth of Mg(ClO4)(2), NaCIO4, and NaClO4-H2O were investigated between 278 and 303 K. In this temperature range, we found that anhydrous Mg(CIO4)(2) was completely converted to Mg(ClO4)(2)center dot 6H(2)O at a relative humidity (RH) as low as &lt;1%. In contrast, anhydrous NaClO4 was stable at RH below 20%, and NaClO4-H2O was completely transformed to anhydrous NaClO4 at &lt;1% RH; when RH was increased to 30%, anhydrous NaC1O(4) was transformed to NaClO4-H2O. We also found that the deliquescence relative humidity (DRH) of NaClO4 H2O decreased from 51.5% at 278 K to 43.5% at 303 K, exhibiting a negative dependence on temperature. In addition, the amounts of water in the NaClO4 solution were quantitatively determined as a function of RH at 278, 288, and 298 K. This work considerably furthers our understanding of the hygroscopic properties of perchlorates under different conditions, as well as the hydrological cycles on Mars and in other hyperarid environments, such as the Atacama Desert on Earth