Symmetry protected fractional Chern insulators and fractional topological insulators

In this paper we construct fully symmetric wavefunctions for the spin-polarized fractional Chern insulators (FCI) and time-reversal-invariant fractional topological insulators (FTI) in two dimensions using the parton approach. We show that the lattice symmetry gives rise to many different FCI and FTI phases even with the same filling fraction $\nu$ (and the same quantized Hall conductance $\sigma_{xy}$ in FCI case). They have different symmetry-protected topological orders, which are characterized by different projective symmetry groups. We mainly focus on FCI phases which are realized in a partially filled band with Chern number one. The low-energy gauge groups of a generic $\sigma_{xy}=1/m\cdot e^2/h$ FCI wavefunctions can be either $SU(m)$ or the discrete group $Z_m$, and in the latter case the associated low-energy physics are described by Chern-Simons-Higgs theories. We use our construction to compute the ground state degeneracy. Examples of FCI/FTI wavefunctions on honeycomb lattice and checkerboard lattice are explicitly given. Possible non-Abelian FCI phases which may be realized in a partially filled band with Chern number two are discussed. Generic FTI wavefunctions in the absence of spin conservation are also presented whose low-energy gauge groups can be either $SU(m)\times SU(m)$ or $Z_m\times Z_m$. The constructed wavefunctions also set up the framework for future variational Monte Carlo simulations.Comment: 24 pages, 13 figures, published versio

δ\delta meson effects on neutron stars in the modified quark-meson coupling model

The properties of neutron stars are investigated by including $\delta$ meson field in the Lagrangian density of modified quark-meson coupling model. The $\Sigma^-$ population with $\delta$ meson is larger than that without $\delta$ meson at the beginning, but it becomes smaller than that without $\delta$ meson as the appearance of $\Xi^-$. The $\delta$ meson has opposite effects on hadronic matter with or without hyperons: it softens the EOSes of hadronic matter with hyperons, while it stiffens the EOSes of pure nucleonic matter. Furthermore, the leptons and the hyperons have the similar influence on $\delta$ meson effects. The $\delta$ meson increases the maximum masses of neutron stars. The influence of $(\sigma^*,\phi)$ on the $\delta$ meson effects are also investigated.Comment: 10 pages, 6 figures, 4 table

Simulation Study on neutrino nucleus cross section measurement in Segmented Detector at Spallation Neutron Source

Knowledge of $\nu_e$-$\mathrm{Fe}/\mathrm{Pb}$ differential cross sections for $\nu_e$ energy below several tens of MeV scale is believed to be crucial in understanding Supernova physics. In a segmented detector at Spallation Neutrino Source, $\nu_e$ energy reconstructed from the electron range measurement is strongly affected because of both multiple scattering and electromagnetic showers occurring along the electron passage in target materials. In order to estimate the effect, a simulation study has been performed with a cube block model assuming a perfect tracking precision. The distortion of energy spectrum is observed to be proportional to the atomic number of target material. Feasibility of unfolding the distorted $\nu_e$ energy spectrum is studied for both Fe and Pb cases. Evaluation of statistical accuracy attainable is therefore provided for a segmented detector.Comment: 6 pages, 6 figures, submitted to Chinese Physics

An exo-cell assay for examining real-time γ-secretase activity and inhibition

γ-Secretase is an aspartyl protease that cleaves multiple substrates that are involved in broad biological processes ranging from stem cell development to neurodegeneration. The investigation of γ-secretase has been limited by currently available assays that require genetic or biochemical manipulation in the form of substrate transfection or membrane preparation. Here we report an exo-cell assay that is capable of characterizing γ-secretase activity in any cellular system without limitation. Using a highly active, recombinant substrate this assay can quickly and easily ascertain the status of γ-secretase activity in cell systems and patient samples. We have applied this method to determine the activity of γ-secretase in primary cell samples where transfection and/or membrane isolation are not viable options. Importantly, it allows for the detection of real time γ-secretase activity after inhibitor or drug treatment. The application of this assay to determine the role of γ-secretase in physiological and pathological conditions will greatly facilitate our characterization of this complex protease and help in the development and evaluation of γ-secretase-targeted therapies in Alzheimer's disease or a variety of neoplasms

Thermokinetic profile of NDM-1 and its inhibition by small carboxylic acids

The New Delhi metallo-β-lactamase (NDM-1) is an important clinical target for antimicrobial research, but there are insufficient clinically useful inhibitors and the details of NDM-1 enzyme catalysis remain unclear. The aim of this work is to provide a thermodynamic profile of NDM-1 catalysed hydrolysis of β-lactams using an isothermal titration calorimetry (ITC) approach and to apply this new method to the identification of new low-molecular-weight dicarboxylic acid inhibitors. The results reveal that hydrolysis of penicillin G and imipenem by NDM-1 share the same thermodynamic features with a significant intrinsic enthalpy change and the release of one proton into solution, while NDM-1 hydrolysis of cefazolin exhibits a different mechanism with a smaller enthalpy change and the release of two protons. The inhibitory constants of four carboxylic acids are found to be in the micromolar range. The compounds pyridine-2,6-dicarboxylic acid and thiazolidine-2,4-dicarboxylic acid show the best inhibitory potency and are confirmed to inhibit NDM-1 using a clinical strain of Escherichia coli. The pyridine compound is further shown to restore the susceptibility of this E. coli strain to imipenem, at an inhibitor concentration of 400 μM, while the thiazoline compound also shows a synergistic effect with imipenem. These results provide valuable information to enrich current understanding on the catalytic mechanism of NDM-1 and to aid the future optimisation of β-lactamase inhibitors based on these scaffolds to tackle the problem of antibiotic resistance

A General SU(2) Formulation for Quantum Searching with Certainty

A general quantum search algorithm with arbitrary unitary transformations and an arbitrary initial state is considered in this work. To serach a marked state with certainty, we have derived, using an SU(2) representation: (1) the matching condition relating the phase rotations in the algorithm, (2) a concise formula for evaluating the required number of iterations for the search, and (3) the final state after the search, with a phase angle in its amplitude of unity modulus. Moreover, the optimal choices and modifications of the phase angles in the Grover kernel is also studied.Comment: 8 pages, 2 figure

A General Phase Matching Condition for Quantum Searching Algorithm

A general consideration on the phase rotations in quantum searching algorithm is taken in this work. As four phase rotations on the initial state, the marked states, and the states orthogonal to them are taken account, we deduce a phase matching condition for a successful search. The optimal options for these phase are obtained consequently.Comment: 3 pages, 3 figure

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

BACKGROUND: Aging has been associated with widespread changes at the gene expression level in multiple mammalian tissues. We have used high density oligonucleotide arrays and novel statistical methods to identify specific transcriptional classes that may uncover biological processes that play a central role in mammalian aging. RESULTS: We identified 712 transcripts that are differentially expressed in young (5 month old) and old (25-month old) mouse skeletal muscle. Caloric restriction (CR) completely or partially reversed 87% of the changes in expression. Examination of individual genes revealed a transcriptional profile indicative of increased p53 activity in the older muscle. To determine whether the increase in p53 activity is associated with transcriptional activation of apoptotic targets, we performed RT-PCR on four well known mediators of p53-induced apoptosis: puma, noxa, tnfrsf10b and bok. Expression levels for these proapoptotic genes increased significantly with age (P < 0.05), while CR significantly lowered expression levels for these genes as compared to control fed old mice (P < 0.05). Age-related induction of p53-related genes was observed in multiple tissues, but was not observed in young SOD2(+/- )and GPX4(+/- )mice, suggesting that oxidative stress does not induce the expression of these genes. Western blot analysis confirmed that protein levels for both p21 and GADD45a, two established transcriptional targets of p53, were higher in the older muscle tissue. CONCLUSION: These observations support a role for p53-mediated transcriptional program in mammalian aging and suggest that mechanisms other than reactive oxygen species are involved in the age-related transcriptional activation of p53 targets